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Murcko scaffold

1-(1-Benzylpiperidin-4-yl)-4-phenylpiperazine scaffold

58 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
58
With full pages
2
Scaffold SMILES

c1ccc(CN2CCC(N3CCN(c4ccccc4)CC3)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(1-Benzylpiperidin-4-yl)-4-phenylpiperazine page
Murcko scaffold c1ccc(CN2CCC(N3CCN(c4ccccc4)CC3)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 58 chemicals

Piperazine, 1-(4-acetylphenyl)-4-(1-benzyl-4-piperidyl)- chemical structure, C24H31N3O, CAS 331978-89-3
Piperazine, 1-(4-acetylphenyl)-4-(1-benzyl-4-piperidyl)-
CAS 331978-89-3C24H31N3O
1-[1-(2-Methylbenzyl)piperidin-4-yl]-4-phenylpiperazine chemical structure, C23H31N3, CAS 500269-26-1
1-[1-(2-Methylbenzyl)piperidin-4-yl]-4-phenylpiperazine
CAS 500269-26-1C23H31N3
1-(1-Benzylpiperidin-4-yl)-4-(2-fluorophenyl)piperazine chemical structure, C22H28FN3, CAS 415971-19-6
1-(1-Benzylpiperidin-4-yl)-4-(2-fluorophenyl)piperazine
CAS 415971-19-6C22H28FN3
1-(1-Benzylpiperidin-4-yl)-4-(2-methoxyphenyl)piperazine chemical structure, C23H31N3O, CAS 415967-82-7
1-(1-Benzylpiperidin-4-yl)-4-(2-methoxyphenyl)piperazine
CAS 415967-82-7C23H31N3O
1-[1-[(4-Bromophenyl)methyl]piperidin-4-yl]-4-phenylpiperazine chemical structure, C22H28BrN3, CAS 497232-10-7
1-[1-[(4-Bromophenyl)methyl]piperidin-4-yl]-4-phenylpiperazine
CAS 497232-10-7C22H28BrN3
1-(2-Methoxyphenyl)-4-[1-[(3-nitrophenyl)methyl]piperidin-4-yl]piperazine chemical structure, C23H30N4O3, CAS 497867-77-3
1-(2-Methoxyphenyl)-4-[1-[(3-nitrophenyl)methyl]piperidin-4-yl]piperazine
CAS 497867-77-3C23H30N4O3
1-[1-[(2-Ethoxyphenyl)methyl]piperidin-4-yl]-4-phenylpiperazine chemical structure, C24H33N3O, CAS 487022-42-4
1-[1-[(2-Ethoxyphenyl)methyl]piperidin-4-yl]-4-phenylpiperazine
CAS 487022-42-4C24H33N3O
1-(2-Fluorophenyl)-4-[1-[(3-methoxyphenyl)methyl]piperidin-4-yl]piperazine chemical structure, C23H30FN3O, CAS 792928-06-4
1-(2-Fluorophenyl)-4-[1-[(3-methoxyphenyl)methyl]piperidin-4-yl]piperazine
CAS 792928-06-4C23H30FN3O
1-(2-Fluorophenyl)-4-[1-[(2-nitrophenyl)methyl]piperidin-4-yl]piperazine chemical structure, C22H27FN4O2, CAS 792928-12-2
1-(2-Fluorophenyl)-4-[1-[(2-nitrophenyl)methyl]piperidin-4-yl]piperazine
CAS 792928-12-2C22H27FN4O2
1-(2-Fluorophenyl)-4-{1-[2-(trifluoromethyl)benzyl]piperidin-4-yl}piperazine chemical structure, C23H27F4N3, CAS 792928-15-5
1-(2-Fluorophenyl)-4-{1-[2-(trifluoromethyl)benzyl]piperidin-4-yl}piperazine
CAS 792928-15-5C23H27F4N3
1-[1-[(3-Bromophenyl)methyl]piperidin-4-yl]-4-(2-methoxyphenyl)piperazine chemical structure, C23H30BrN3O, CAS 488803-78-7
1-[1-[(3-Bromophenyl)methyl]piperidin-4-yl]-4-(2-methoxyphenyl)piperazine
CAS 488803-78-7C23H30BrN3O
1-(2-Fluorophenyl)-4-[1-[(4-nitrophenyl)methyl]piperidin-4-yl]piperazine chemical structure, C22H27FN4O2, CAS 792928-13-3
1-(2-Fluorophenyl)-4-[1-[(4-nitrophenyl)methyl]piperidin-4-yl]piperazine
CAS 792928-13-3C22H27FN4O2
1-(2-Methoxyphenyl)-4-[1-[(3-methoxyphenyl)methyl]piperidin-4-yl]piperazine chemical structure, C24H33N3O2, CAS 431981-12-3
1-(2-Methoxyphenyl)-4-[1-[(3-methoxyphenyl)methyl]piperidin-4-yl]piperazine
CAS 431981-12-3C24H33N3O2
1-(2-Fluorophenyl)-4-[1-[(4-methylsulfanylphenyl)methyl]piperidin-4-yl]piperazine chemical structure, C23H30FN3S, CAS 792928-11-1
1-(2-Fluorophenyl)-4-[1-[(4-methylsulfanylphenyl)methyl]piperidin-4-yl]piperazine
CAS 792928-11-1C23H30FN3S
1-[1-[(4-Methylsulfanylphenyl)methyl]piperidin-4-yl]-4-phenylpiperazine chemical structure, C23H31N3S, CAS 500145-89-1
1-[1-[(4-Methylsulfanylphenyl)methyl]piperidin-4-yl]-4-phenylpiperazine
CAS 500145-89-1C23H31N3S
1-(2-Methoxyphenyl)-4-[1-[(4-nitrophenyl)methyl]piperidin-4-yl]piperazine chemical structure, C23H30N4O3, CAS 489403-56-7
1-(2-Methoxyphenyl)-4-[1-[(4-nitrophenyl)methyl]piperidin-4-yl]piperazine
CAS 489403-56-7C23H30N4O3
1-[1-[(3-Fluorophenyl)methyl]piperidin-4-yl]-4-(2-methoxyphenyl)piperazine chemical structure, C23H30FN3O, CAS 432002-48-7
1-[1-[(3-Fluorophenyl)methyl]piperidin-4-yl]-4-(2-methoxyphenyl)piperazine
CAS 432002-48-7C23H30FN3O
1-[1-[(3-Chlorophenyl)methyl]piperidin-4-yl]-4-(2-methoxyphenyl)piperazine chemical structure, C23H30ClN3O, CAS 432003-42-4
1-[1-[(3-Chlorophenyl)methyl]piperidin-4-yl]-4-(2-methoxyphenyl)piperazine
CAS 432003-42-4C23H30ClN3O
1-(2-Methoxyphenyl)-4-[1-[(2-methoxyphenyl)methyl]piperidin-4-yl]piperazine chemical structure, C24H33N3O2, CAS 432004-96-1
1-(2-Methoxyphenyl)-4-[1-[(2-methoxyphenyl)methyl]piperidin-4-yl]piperazine
CAS 432004-96-1C24H33N3O2
1-[1-[(4-Ethoxyphenyl)methyl]piperidin-4-yl]-4-phenylpiperazine chemical structure, C24H33N3O, CAS 488093-16-9
1-[1-[(4-Ethoxyphenyl)methyl]piperidin-4-yl]-4-phenylpiperazine
CAS 488093-16-9C24H33N3O
1-[1-[(4-Bromophenyl)methyl]-4-piperidinyl]-4-(2-methoxyphenyl)piperazine chemical structure, C23H30BrN3O, CAS 432007-41-5
1-[1-[(4-Bromophenyl)methyl]-4-piperidinyl]-4-(2-methoxyphenyl)piperazine
CAS 432007-41-5C23H30BrN3O
4-Bromo-2-[[4-(4-phenylpiperazin-1-yl)piperidin-1-yl]methyl]phenol chemical structure, C22H28BrN3O, CAS 792928-25-7
4-Bromo-2-[[4-(4-phenylpiperazin-1-yl)piperidin-1-yl]methyl]phenol
CAS 792928-25-7C22H28BrN3O
1-[1-[(2-Nitrophenyl)methyl]piperidin-4-yl]-4-phenylpiperazine chemical structure, C22H28N4O2, CAS 487032-10-0
1-[1-[(2-Nitrophenyl)methyl]piperidin-4-yl]-4-phenylpiperazine
CAS 487032-10-0C22H28N4O2
1-[1-(4-Chlorobenzyl)piperidin-4-yl]-4-(2-methoxyphenyl)piperazine chemical structure, C23H30ClN3O, CAS 432013-24-6
1-[1-(4-Chlorobenzyl)piperidin-4-yl]-4-(2-methoxyphenyl)piperazine
CAS 432013-24-6C23H30ClN3O