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Murcko scaffold

1-(1-Benzoyl-4-piperidinyl)-4-phenylpiperazine scaffold

20 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
20
With full pages
6
Scaffold SMILES

O=C(c1ccccc1)N1CCC(N2CCN(c3ccccc3)CC2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(1-Benzoyl-4-piperidinyl)-4-phenylpiperazine page
Murcko scaffold O=C(c1ccccc1)N1CCC(N2CCN(c3ccccc3)CC2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

[4-[4-(2-Methoxyphenyl)piperazin-1-yl]piperidin-1-yl]-(3,4,5-trimethoxyphenyl)methanone chemical structure, C26H35N3O5, CAS 431926-40-8
[4-[4-(2-Methoxyphenyl)piperazin-1-yl]piperidin-1-yl]-(3,4,5-trimethoxyphenyl)methanone
CAS 431926-40-8C26H35N3O5
(3,5-Dimethoxyphenyl)-[4-(4-phenylpiperazin-1-yl)piperidin-1-yl]methanone chemical structure, C24H31N3O3, CAS 489422-48-2
(3,5-Dimethoxyphenyl)-[4-(4-phenylpiperazin-1-yl)piperidin-1-yl]methanone
CAS 489422-48-2C24H31N3O3
(3,4-Dimethoxyphenyl)-[4-(4-phenylpiperazin-1-yl)piperidin-1-yl]methanone chemical structure, C24H31N3O3, CAS 500276-09-5
(3,4-Dimethoxyphenyl)-[4-(4-phenylpiperazin-1-yl)piperidin-1-yl]methanone
CAS 500276-09-5C24H31N3O3
1-(1-Benzoyl-4-piperidinyl)-4-phenylpiperazine chemical structure, C22H27N3O, CAS 488795-86-4
1-(1-Benzoyl-4-piperidinyl)-4-phenylpiperazine
CAS 488795-86-4C22H27N3O
(4-Fluorophenyl){4-[4-(2-methoxyphenyl)piperazin-1-yl]piperidin-1-yl}methanone chemical structure, C23H28FN3O2, CAS 431938-59-9
(4-Fluorophenyl){4-[4-(2-methoxyphenyl)piperazin-1-yl]piperidin-1-yl}methanone
CAS 431938-59-9C23H28FN3O2
(2-Methoxyphenyl)[4-(4-phenylpiperazin-1-yl)piperidin-1-yl]methanone chemical structure, C23H29N3O2, CAS 496772-24-8
(2-Methoxyphenyl)[4-(4-phenylpiperazin-1-yl)piperidin-1-yl]methanone
CAS 496772-24-8C23H29N3O2
(3-Fluorophenyl)-[4-[4-(2-fluorophenyl)piperazin-1-yl]piperidin-1-yl]methanone chemical structure, C22H25F2N3O, CAS 834895-84-0
(3-Fluorophenyl)-[4-[4-(2-fluorophenyl)piperazin-1-yl]piperidin-1-yl]methanone
CAS 834895-84-0C22H25F2N3O
(3-Chlorophenyl)-[4-(4-phenylpiperazin-1-yl)piperidin-1-yl]methanone chemical structure, C22H26ClN3O, CAS 500278-26-2
(3-Chlorophenyl)-[4-(4-phenylpiperazin-1-yl)piperidin-1-yl]methanone
CAS 500278-26-2C22H26ClN3O
(3-Fluorophenyl)-[4-[4-(2-methoxyphenyl)piperazin-1-yl]piperidin-1-yl]methanone chemical structure, C23H28FN3O2, CAS 488860-78-2
(3-Fluorophenyl)-[4-[4-(2-methoxyphenyl)piperazin-1-yl]piperidin-1-yl]methanone
CAS 488860-78-2C23H28FN3O2
(4-Methoxyphenyl)-[4-(4-phenylpiperazin-1-yl)piperidin-1-yl]methanone chemical structure, C23H29N3O2, CAS 499210-59-2
(4-Methoxyphenyl)-[4-(4-phenylpiperazin-1-yl)piperidin-1-yl]methanone
CAS 499210-59-2C23H29N3O2
(2-Fluorophenyl)-[4-(4-phenylpiperazin-1-yl)piperidin-1-yl]methanone chemical structure, C22H26FN3O, CAS 499211-29-9
(2-Fluorophenyl)-[4-(4-phenylpiperazin-1-yl)piperidin-1-yl]methanone
CAS 499211-29-9C22H26FN3O
(4-Methoxyphenyl)-[4-[4-(2-methoxyphenyl)piperazin-1-yl]piperidin-1-yl]methanone chemical structure, C24H31N3O3, CAS 432000-05-0
(4-Methoxyphenyl)-[4-[4-(2-methoxyphenyl)piperazin-1-yl]piperidin-1-yl]methanone
CAS 432000-05-0C24H31N3O3
[4-[4-(2-Methoxyphenyl)piperazin-1-yl]piperidin-1-yl]-phenylmethanone chemical structure, C23H29N3O2, CAS 488744-51-0
[4-[4-(2-Methoxyphenyl)piperazin-1-yl]piperidin-1-yl]-phenylmethanone
CAS 488744-51-0C23H29N3O2
(3-Fluorophenyl)-[4-(4-phenylpiperazin-1-yl)piperidin-1-yl]methanone chemical structure, C22H26FN3O, CAS 500148-07-2
(3-Fluorophenyl)-[4-(4-phenylpiperazin-1-yl)piperidin-1-yl]methanone
CAS 500148-07-2C22H26FN3O
(2-Methoxyphenyl)-[4-[4-(2-methoxyphenyl)piperazin-1-yl]piperidin-1-yl]methanone chemical structure, C24H31N3O3, CAS 488804-89-3
(2-Methoxyphenyl)-[4-[4-(2-methoxyphenyl)piperazin-1-yl]piperidin-1-yl]methanone
CAS 488804-89-3C24H31N3O3
(2-Chlorophenyl)-[4-(4-phenylpiperazin-1-yl)piperidin-1-yl]methanone chemical structure, C22H26ClN3O, CAS 488842-94-0
(2-Chlorophenyl)-[4-(4-phenylpiperazin-1-yl)piperidin-1-yl]methanone
CAS 488842-94-0C22H26ClN3O
(3,5-Dimethoxyphenyl)(4-(4-(2-methoxyphenyl)piperazin-1-yl)piperidin-1-yl)methanone 2,2,2-trifluoroacetate chemical structure, C27H34F3N3O6, CAS 1164562-43-9
(3,5-Dimethoxyphenyl)(4-(4-(2-methoxyphenyl)piperazin-1-yl)piperidin-1-yl)methanone 2,2,2-trifluoroacetate
CAS 1164562-43-9C27H34F3N3O6
(3,5-Dimethoxyphenyl)-[4-[4-(2-methoxyphenyl)piperazin-1-yl]piperidin-1-yl]methanone chemical structure, C25H33N3O4, CAS 432008-78-1
(3,5-Dimethoxyphenyl)-[4-[4-(2-methoxyphenyl)piperazin-1-yl]piperidin-1-yl]methanone
CAS 432008-78-1C25H33N3O4
[4-[4-(2-Fluorophenyl)piperazin-1-yl]piperidin-1-yl]-(3,4,5-trimethoxyphenyl)methanone chemical structure, C25H32FN3O4, CAS 792929-62-5
[4-[4-(2-Fluorophenyl)piperazin-1-yl]piperidin-1-yl]-(3,4,5-trimethoxyphenyl)methanone
CAS 792929-62-5C25H32FN3O4
(2,6-Dimethylphenyl)(4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)piperidin-1-yl)methanone chemical structure, C25H30F3N3O, CAS 2034495-24-2
(2,6-Dimethylphenyl)(4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)piperidin-1-yl)methanone
CAS 2034495-24-2C25H30F3N3O