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Murcko scaffold

Ring system with 2 rings and 15 atoms

61 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
61
With full pages
3
Scaffold SMILES

S=C(Nc1ccccc1)Nc1cccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold S=C(Nc1ccccc1)Nc1cccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 61 chemicals

4,5-Dimethyl-2-(phenylcarbamothioylamino)thiophene-3-carboxamide chemical structure, C14H15N3OS2, CAS 433315-22-1
4,5-Dimethyl-2-(phenylcarbamothioylamino)thiophene-3-carboxamide
CAS 433315-22-1C14H15N3OS2
Ethyl 5-methyl-2-(phenylcarbamothioylamino)thiophene-3-carboxylate chemical structure, C15H16N2O2S2, CAS 461430-18-2
Ethyl 5-methyl-2-(phenylcarbamothioylamino)thiophene-3-carboxylate
CAS 461430-18-2C15H16N2O2S2
4,5-Dimethyl-2-(3-phenyl-thioureido)-thiophene-3-carboxylic acid ethyl ester chemical structure, C16H18N2O2S2, CAS 59898-45-2
4,5-Dimethyl-2-(3-phenyl-thioureido)-thiophene-3-carboxylic acid ethyl ester
CAS 59898-45-2C16H18N2O2S2
Methyl 2-({[3-chloro-4-(difluoromethoxy)phenyl]carbamothioyl}amino)-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate chemical structure, C20H22ClF2N3O4S2, CAS 701950-04-1
Methyl 2-({[3-chloro-4-(difluoromethoxy)phenyl]carbamothioyl}amino)-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate
CAS 701950-04-1C20H22ClF2N3O4S2
Methyl 2-{[(5-chloro-2,4-dimethoxyphenyl)carbamothioyl]amino}-5-ethylthiophene-3-carboxylate chemical structure, C17H19ClN2O4S2, CAS 708225-45-0
Methyl 2-{[(5-chloro-2,4-dimethoxyphenyl)carbamothioyl]amino}-5-ethylthiophene-3-carboxylate
CAS 708225-45-0C17H19ClN2O4S2
Methyl 2-{[(2-chlorophenyl)carbamothioyl]amino}-4,5-dimethylthiophene-3-carboxylate chemical structure, C15H15ClN2O2S2, CAS 588711-02-8
Methyl 2-{[(2-chlorophenyl)carbamothioyl]amino}-4,5-dimethylthiophene-3-carboxylate
CAS 588711-02-8C15H15ClN2O2S2
Methyl 2-({[4,5-dimethoxy-2-(methoxycarbonyl)phenyl]carbamothioyl}amino)-4-ethyl-5-methylthiophene-3-carboxylate chemical structure, C20H24N2O6S2, CAS 701283-16-1
Methyl 2-({[4,5-dimethoxy-2-(methoxycarbonyl)phenyl]carbamothioyl}amino)-4-ethyl-5-methylthiophene-3-carboxylate
CAS 701283-16-1C20H24N2O6S2
Methyl 2-({[2-(difluoromethoxy)-4-methylphenyl]carbamothioyl}amino)-5-ethylthiophene-3-carboxylate chemical structure, C17H18F2N2O3S2, CAS 701926-62-7
Methyl 2-({[2-(difluoromethoxy)-4-methylphenyl]carbamothioyl}amino)-5-ethylthiophene-3-carboxylate
CAS 701926-62-7C17H18F2N2O3S2
Methyl 2-({[4-(ethylsulfamoyl)phenyl]carbamothioyl}amino)-4,5-dimethylthiophene-3-carboxylate chemical structure, C17H21N3O4S3, CAS 701931-54-6
Methyl 2-({[4-(ethylsulfamoyl)phenyl]carbamothioyl}amino)-4,5-dimethylthiophene-3-carboxylate
CAS 701931-54-6C17H21N3O4S3
Methyl 5-(dimethylcarbamoyl)-4-methyl-2-({[2-(methylsulfanyl)phenyl]carbamothioyl}amino)thiophene-3-carboxylate chemical structure, C18H21N3O3S3, CAS 701933-38-2
Methyl 5-(dimethylcarbamoyl)-4-methyl-2-({[2-(methylsulfanyl)phenyl]carbamothioyl}amino)thiophene-3-carboxylate
CAS 701933-38-2C18H21N3O3S3
Methyl 2-{[(3,4-difluorophenyl)carbamothioyl]amino}-4,5-dimethylthiophene-3-carboxylate chemical structure, C15H14F2N2O2S2, CAS 706776-37-6
Methyl 2-{[(3,4-difluorophenyl)carbamothioyl]amino}-4,5-dimethylthiophene-3-carboxylate
CAS 706776-37-6C15H14F2N2O2S2
Diethyl 5-({[3-chloro-4-(difluoromethoxy)phenyl]carbamothioyl}amino)-3-methylthiophene-2,4-dicarboxylate chemical structure, C19H19ClF2N2O5S2, CAS 708219-74-3
Diethyl 5-({[3-chloro-4-(difluoromethoxy)phenyl]carbamothioyl}amino)-3-methylthiophene-2,4-dicarboxylate
CAS 708219-74-3C19H19ClF2N2O5S2
Methyl 2-{[(4-bromo-2-chlorophenyl)carbamothioyl]amino}-5-(dimethylcarbamoyl)-4-methylthiophene-3-carboxylate chemical structure, C17H17BrClN3O3S2, CAS 708229-69-0
Methyl 2-{[(4-bromo-2-chlorophenyl)carbamothioyl]amino}-5-(dimethylcarbamoyl)-4-methylthiophene-3-carboxylate
CAS 708229-69-0C17H17BrClN3O3S2
Methyl 2-{[(4-bromo-3-chlorophenyl)carbamothioyl]amino}-4,5-dimethylthiophene-3-carboxylate chemical structure, C15H14BrClN2O2S2, CAS 708236-72-0
Methyl 2-{[(4-bromo-3-chlorophenyl)carbamothioyl]amino}-4,5-dimethylthiophene-3-carboxylate
CAS 708236-72-0C15H14BrClN2O2S2
Methyl 2-{[(4-ethoxy-2-nitrophenyl)carbamothioyl]amino}-4-ethyl-5-methylthiophene-3-carboxylate chemical structure, C18H21N3O5S2, CAS 701951-80-6
Methyl 2-{[(4-ethoxy-2-nitrophenyl)carbamothioyl]amino}-4-ethyl-5-methylthiophene-3-carboxylate
CAS 701951-80-6C18H21N3O5S2
Methyl 5-(diethylcarbamoyl)-2-{[(4-ethoxy-2-nitrophenyl)carbamothioyl]amino}-4-methylthiophene-3-carboxylate chemical structure, C21H26N4O6S2, CAS 701967-10-4
Methyl 5-(diethylcarbamoyl)-2-{[(4-ethoxy-2-nitrophenyl)carbamothioyl]amino}-4-methylthiophene-3-carboxylate
CAS 701967-10-4C21H26N4O6S2
Methyl 5-ethyl-2-{[(4-methoxy-2-nitrophenyl)carbamothioyl]amino}thiophene-3-carboxylate chemical structure, C16H17N3O5S2, CAS 706762-91-6
Methyl 5-ethyl-2-{[(4-methoxy-2-nitrophenyl)carbamothioyl]amino}thiophene-3-carboxylate
CAS 706762-91-6C16H17N3O5S2
Methyl 5-methyl-2-{[(2-nitrophenyl)carbamothioyl]amino}thiophene-3-carboxylate chemical structure, C14H13N3O4S2, CAS 708222-00-8
Methyl 5-methyl-2-{[(2-nitrophenyl)carbamothioyl]amino}thiophene-3-carboxylate
CAS 708222-00-8C14H13N3O4S2
Methyl 2-{[(2-methoxy-4-nitrophenyl)carbamothioyl]amino}-4,5-dimethylthiophene-3-carboxylate chemical structure, C16H17N3O5S2, CAS 708226-09-9
Methyl 2-{[(2-methoxy-4-nitrophenyl)carbamothioyl]amino}-4,5-dimethylthiophene-3-carboxylate
CAS 708226-09-9C16H17N3O5S2
Methyl 5-(dimethylcarbamoyl)-2-{[(4-fluoro-2-nitrophenyl)carbamothioyl]amino}-4-methylthiophene-3-carboxylate chemical structure, C17H17FN4O5S2, CAS 708230-39-1
Methyl 5-(dimethylcarbamoyl)-2-{[(4-fluoro-2-nitrophenyl)carbamothioyl]amino}-4-methylthiophene-3-carboxylate
CAS 708230-39-1C17H17FN4O5S2
Methyl 5-(diethylcarbamoyl)-2-({[4,5-dimethoxy-2-(methoxycarbonyl)phenyl]carbamothioyl}amino)-4-methylthiophene-3-carboxylate chemical structure, C23H29N3O7S2, CAS 708231-18-9
Methyl 5-(diethylcarbamoyl)-2-({[4,5-dimethoxy-2-(methoxycarbonyl)phenyl]carbamothioyl}amino)-4-methylthiophene-3-carboxylate
CAS 708231-18-9C23H29N3O7S2
Methyl 5-ethyl-2-{[(3-ethylphenyl)carbamothioyl]amino}thiophene-3-carboxylate chemical structure, C17H20N2O2S2, CAS 590353-84-7
Methyl 5-ethyl-2-{[(3-ethylphenyl)carbamothioyl]amino}thiophene-3-carboxylate
CAS 590353-84-7C17H20N2O2S2
Methyl 5-ethyl-2-{[(2-ethylphenyl)carbamothioyl]amino}thiophene-3-carboxylate chemical structure, C17H20N2O2S2, CAS 590353-88-1
Methyl 5-ethyl-2-{[(2-ethylphenyl)carbamothioyl]amino}thiophene-3-carboxylate
CAS 590353-88-1C17H20N2O2S2
Methyl 5-ethyl-2-{[(4-ethylphenyl)carbamothioyl]amino}thiophene-3-carboxylate chemical structure, C17H20N2O2S2, CAS 590353-90-5
Methyl 5-ethyl-2-{[(4-ethylphenyl)carbamothioyl]amino}thiophene-3-carboxylate
CAS 590353-90-5C17H20N2O2S2