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Murcko scaffold

Ring system with 2 rings and 13 atoms

14 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
14
With full pages
7
Scaffold SMILES

O=C(Nc1nccs1)c1cnoc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1nccs1)c1cnoc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

3-Ethyl-5-methyl-N-(5-methylthiazol-2-yl)isoxazole-4-carboxamide chemical structure, C11H13N3O2S, CAS 438223-98-4
3-Ethyl-5-methyl-N-(5-methylthiazol-2-yl)isoxazole-4-carboxamide
CAS 438223-98-4C11H13N3O2S
5-Methyl-N4-(thiazol-2-yl)isoxazole-3,4-dicarboxamide chemical structure, C9H8N4O3S, CAS 338408-95-0
5-Methyl-N4-(thiazol-2-yl)isoxazole-3,4-dicarboxamide
CAS 338408-95-0C9H8N4O3S
3,5-Dimethyl-N-(5-methyl-1,3-thiazol-2-yl)-1,2-oxazole-4-carboxamide chemical structure, C10H11N3O2S, CAS 438218-15-6
3,5-Dimethyl-N-(5-methyl-1,3-thiazol-2-yl)-1,2-oxazole-4-carboxamide
CAS 438218-15-6C10H11N3O2S
Methyl 2-{[(3,5-dimethyl-1,2-oxazol-4-yl)carbonyl]amino}-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C12H13N3O4S, CAS 777868-49-2
Methyl 2-{[(3,5-dimethyl-1,2-oxazol-4-yl)carbonyl]amino}-4-methyl-1,3-thiazole-5-carboxylate
CAS 777868-49-2C12H13N3O4S
3,5-Dimethyl-N-(1,3-thiazol-2-yl)-1,2-oxazole-4-carboxamide chemical structure, C9H9N3O2S, CAS 54294-96-1
3,5-Dimethyl-N-(1,3-thiazol-2-yl)-1,2-oxazole-4-carboxamide
CAS 54294-96-1C9H9N3O2S
Ethyl 5-methyl-4-[(1,3-thiazol-2-ylamino)carbonyl]-3-isoxazolecarboxylate chemical structure, C11H11N3O4S, CAS 338408-87-0
Ethyl 5-methyl-4-[(1,3-thiazol-2-ylamino)carbonyl]-3-isoxazolecarboxylate
CAS 338408-87-0C11H11N3O4S
3-(Hydroxymethyl)-5-methyl-N-(1,3-thiazol-2-yl)-4-isoxazolecarboxamide chemical structure, C9H9N3O3S, CAS 338408-93-8
3-(Hydroxymethyl)-5-methyl-N-(1,3-thiazol-2-yl)-4-isoxazolecarboxamide
CAS 338408-93-8C9H9N3O3S
3-Acetyl-5-methyl-N-(1,3-thiazol-2-yl)-1,2-oxazole-4-carboxamide chemical structure, C10H9N3O3S, CAS 338794-74-4
3-Acetyl-5-methyl-N-(1,3-thiazol-2-yl)-1,2-oxazole-4-carboxamide
CAS 338794-74-4C10H9N3O3S
3-[3-(Dimethylamino)acryloyl]-5-methyl-N-(1,3-thiazol-2-yl)-4-isoxazolecarboxamide chemical structure, C13H14N4O3S, CAS 1164541-48-3
3-[3-(Dimethylamino)acryloyl]-5-methyl-N-(1,3-thiazol-2-yl)-4-isoxazolecarboxamide
CAS 1164541-48-3C13H14N4O3S
N-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-3,5-dimethyl-1,2-oxazole-4-carboxamide chemical structure, C12H13N3O3S, CAS 873812-61-4
N-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-3,5-dimethyl-1,2-oxazole-4-carboxamide
CAS 873812-61-4C12H13N3O3S
5-Methyl-N-(5-nitrothiazol-2-yl)isoxazole-4-carboxamide chemical structure, C8H6N4O4S, CAS 738531-66-3
5-Methyl-N-(5-nitrothiazol-2-yl)isoxazole-4-carboxamide
CAS 738531-66-3C8H6N4O4S
Methyl 2-{[(3,5-dimethyl-4-isoxazolyl)carbonyl]amino}-5-isopropyl-1,3-thiazole-4-carboxylate chemical structure, C14H17N3O4S, CAS 1401600-67-6
Methyl 2-{[(3,5-dimethyl-4-isoxazolyl)carbonyl]amino}-5-isopropyl-1,3-thiazole-4-carboxylate
CAS 1401600-67-6C14H17N3O4S
5-Methyl-N-(1,3-thiazol-2-yl)-1,2-oxazole-4-carboxamide chemical structure, C8H7N3O2S, CAS 1454585-15-9
5-Methyl-N-(1,3-thiazol-2-yl)-1,2-oxazole-4-carboxamide
CAS 1454585-15-9C8H7N3O2S
3-(Hydroxyethanimidoyl)-5-methyl-N-(1,3-thiazol-2-yl)-4-isoxazolecarboxamide chemical structure, C10H10N4O3S, CAS 338794-81-3
3-(Hydroxyethanimidoyl)-5-methyl-N-(1,3-thiazol-2-yl)-4-isoxazolecarboxamide
CAS 338794-81-3C10H10N4O3S