Murcko scaffold
Ring system with 2 rings and 13 atoms
71 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 13
- Chemicals
- 71
- With full pages
- 16
Scaffold SMILES
O=C(Nc1cccs1)c1cccs1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 71 chemicals
![Methyl 4-ethyl-5-methyl-2-[(thiophen-2-ylcarbonyl)amino]thiophene-3-carboxylate chemical structure, C14H15NO3S2, CAS 329207-58-1](/s/RFVQTPYTQBSEPF-UHFFFAOYSA-N.svg)
Methyl 4-ethyl-5-methyl-2-[(thiophen-2-ylcarbonyl)amino]thiophene-3-carboxylate
CAS 329207-58-1C14H15NO3S2
![N-[3-(Aminocarbonyl)-4,5-dimethyl-2-thienyl]-2-thiophenecarboxamide chemical structure, C12H12N2O2S2, CAS 329221-59-2](/s/OTIUGBVMROZGTK-UHFFFAOYSA-N.svg)
N-[3-(Aminocarbonyl)-4,5-dimethyl-2-thienyl]-2-thiophenecarboxamide
CAS 329221-59-2C12H12N2O2S2
Ethyl 5-ethyl-2-(thiophene-2-carboxamido)thiophene-3-carboxylate
CAS 312279-77-9C14H15NO3S2
4-Ethyl-5-methyl-2-(thiophene-2-carbonylamino)thiophene-3-carboxamide
CAS 352678-03-6C13H14N2O2S2
Ethyl 4-cyano-3-methyl-5-(thiophene-2-carboxamido)thiophene-2-carboxylate
CAS 449177-12-2C14H12N2O3S2
![Methyl 4,5-dimethyl-2-[(2-thienylcarbonyl)amino]-3-thiophenecarboxylate chemical structure, C13H13NO3S2, CAS 353764-79-1](/s/BDFWXHIKQNYOID-UHFFFAOYSA-N.svg)
Methyl 4,5-dimethyl-2-[(2-thienylcarbonyl)amino]-3-thiophenecarboxylate
CAS 353764-79-1C13H13NO3S2
4,5-Dimethyl-2-(thiophene-2-carbonylamino)thiophene-3-carboxylic acid
CAS 461438-34-6C12H11NO3S2
Ethyl 5-acetyl-4-methyl-2-(thiophene-2-carbonylamino)thiophene-3-carboxylate
CAS 412939-37-8C15H15NO4S2
N-(3-Cyano-4-ethyl-5-methylthiophen-2-yl)thiophene-2-carboxamide
CAS 418789-27-2C13H12N2OS2
Methyl 5-methyl-2-(thiophene-2-carbonylamino)thiophene-3-carboxylate
CAS 496017-39-1C12H11NO3S2
Propan-2-yl 4-ethyl-5-methyl-2-(thiophene-2-carbonylamino)thiophene-3-carboxylate
CAS 353787-94-7C16H19NO3S2
Ethyl 4-ethyl-5-methyl-2-(thiophene-2-carbonylamino)thiophene-3-carboxylate
CAS 353477-21-1C15H17NO3S2
![3-Methyl-5-[(thiophene-2-carbonyl)amino]thiophene-2,4-dicarboxylic acid, dimethyl ester chemical structure, C14H13NO5S2, CAS 544427-02-3](/s/XHTMWHNEEQHQNW-UHFFFAOYSA-N.svg)
3-Methyl-5-[(thiophene-2-carbonyl)amino]thiophene-2,4-dicarboxylic acid, dimethyl ester
CAS 544427-02-3C14H13NO5S2
![Diethyl 3-methyl-5-[(thien-2-ylcarbonyl)amino]thiophene-2,4-dicarboxylate chemical structure, C16H17NO5S2, CAS 307524-40-9](/s/HDUZFQLJCUEMDS-UHFFFAOYSA-N.svg)
Diethyl 3-methyl-5-[(thien-2-ylcarbonyl)amino]thiophene-2,4-dicarboxylate
CAS 307524-40-9C16H17NO5S2
Methyl 5-(diethylcarbamoyl)-4-methyl-2-(thiophene-2-carboxamido)thiophene-3-carboxylate
CAS 438619-11-5C17H20N2O4S2
Ethyl 5-(diethylcarbamoyl)-4-methyl-2-(thiophene-2-carbonylamino)thiophene-3-carboxylate
CAS 352693-95-9C18H22N2O4S2
5-Chloro-N-(3-cyano-4,5-dimethylthiophen-2-yl)thiophene-2-carboxamide
CAS 515859-58-2C12H9ClN2OS2
![Methyl 2-{[(4-bromo-2-thienyl)carbonyl]amino}-5-ethyl-3-thiophenecarboxylate chemical structure, C13H12BrNO3S2, CAS 775301-55-8](/s/YQTMWTXOXSAWJH-UHFFFAOYSA-N.svg)
Methyl 2-{[(4-bromo-2-thienyl)carbonyl]amino}-5-ethyl-3-thiophenecarboxylate
CAS 775301-55-8C13H12BrNO3S2
5-Bromo-N-(3-carbamoyl-4,5-dimethylthiophen-2-yl)thiophene-2-carboxamide
CAS 717856-81-0C12H11BrN2O2S2
Methyl 2-(5-chlorothiophene-2-carboxamido)-4,5-dimethylthiophene-3-carboxylate
CAS 717857-94-8C13H12ClNO3S2
![2-[(5-Chlorothiophene-2-carbonyl)amino]-4,5-dimethylthiophene-3-carboxamide chemical structure, C12H11ClN2O2S2, CAS 717858-14-5](/s/BFCDSWDRSWYOSX-UHFFFAOYSA-N.svg)
2-[(5-Chlorothiophene-2-carbonyl)amino]-4,5-dimethylthiophene-3-carboxamide
CAS 717858-14-5C12H11ClN2O2S2
![Methyl 5-carbamoyl-4-methyl-2-[(thiophen-2-ylcarbonyl)amino]thiophene-3-carboxylate chemical structure, C13H12N2O4S2, CAS 444934-92-3](/s/TXWWGGONQQDBON-UHFFFAOYSA-N.svg)
Methyl 5-carbamoyl-4-methyl-2-[(thiophen-2-ylcarbonyl)amino]thiophene-3-carboxylate
CAS 444934-92-3C13H12N2O4S2
N-(3-Cyanothiophen-2-yl)thiophene-2-carboxamide
CAS 865545-78-4C10H6N2OS2
N-(3-Cyanothiophen-2-yl)-5-nitrothiophene-2-carboxamide
CAS 865545-83-1C10H5N3O3S2
- 5-Bromo-N-(3-cyanothiophen-2-yl)thiophene-2-carboxamide865545-85-3C10H5BrN2OS2
- Ethyl 5-carbamoyl-4-methyl-2-(thiophene-2-carbonylamino)thiophene-3-carboxylate353787-42-5C14H14N2O4S2
- 4-Bromo-N-(3-cyano-4,5-dimethylthiophen-2-yl)-5-ethylthiophene-2-carboxamide777873-62-8C14H13BrN2OS2
- Methyl 2-{[(4-bromothiophen-2-yl)carbonyl]amino}-5-carbamoyl-4-methylthiophene-3-carboxylate777868-71-0C13H11BrN2O4S2
- Diethyl 5-(5-chlorothiophene-2-carboxamido)-3-methylthiophene-2,4-dicarboxylate379701-22-1C16H16ClNO5S2
- Ethyl 3-methyl-5-[(3-methylthiophene-2-carbonyl)amino]thiophene-2-carboxylate378223-81-5C14H15NO3S2
- Methyl 2-[(2-thienylcarbonyl)amino]thiophene-3-carboxylate271778-23-5C11H9NO3S2
- Dipropan-2-yl 3-methyl-5-(thiophene-2-carbonylamino)thiophene-2,4-dicarboxylate352682-89-4C18H21NO5S2
- 2-(Thiophene-2-amido)thiophene-3-carboxamide56843-75-5C10H8N2O2S2
- 4-Ethyl 2-methyl 3-methyl-5-[(2-thienylcarbonyl)amino]-2,4-thiophenedicarboxylate839686-77-0C15H15NO5S2
- Ethyl 3-methyl-5-(thiophene-2-carboxamido)thiophene-2-carboxylate380451-48-9C13H13NO3S2
- Ethyl 2-(thiophene-2-carboxamido)thiophene-3-carboxylate864940-46-5C12H11NO3S2
- Ethyl 4,5-dimethyl-2-(5-nitrothiophene-2-carboxamido)thiophene-3-carboxylate391867-05-3C14H14N2O5S2
- Ethyl (2-(5-nitrothiophene-2-carboxamido)thiophene-3-carbonyl)carbamate864941-31-1C13H11N3O6S2
- N-(3-(Methylcarbamoyl)thiophen-2-yl)-5-nitrothiophene-2-carboxamide864974-61-8C11H9N3O4S2
- N-(3-(Methylcarbamoyl)thiophen-2-yl)thiophene-2-carboxamide864974-55-0C11H10N2O2S2
- N-(3-Carbamoylthiophen-2-yl)-5-nitrothiophene-2-carboxamide852558-33-9C10H7N3O4S2
- Ethyl 2-(5-chlorothiophene-2-carboxamido)-5-nitrothiophene-3-carboxylate477491-15-9C12H9ClN2O5S2
- Ethyl 2-(5-chlorothiophene-2-carboxamido)-4,5-dimethylthiophene-3-carboxylate391867-11-1C14H14ClNO3S2
- Ethyl 5-(5-chlorothiophene-2-carboxamido)-3-methyl-4-thiocyanatothiophene-2-carboxylate681159-95-5C14H11ClN2O3S3
- 2-[(5-Chlorothiophene-2-carbonyl)amino]-N-methylthiophene-3-carboxamide864974-84-5C11H9ClN2O2S2
- Methyl 2-(5-chlorothiophene-2-carboxamido)thiophene-3-carboxylate864940-41-0C11H8ClNO3S2
- Ethyl 5-[(5-chlorothiophene-2-carbonyl)amino]-3-methylthiophene-2-carboxylate477567-71-8C13H12ClNO3S2
- 2-[(5-Bromothiophene-2-carbonyl)amino]thiophene-3-carboxamide864940-75-0C10H7BrN2O2S2
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(N=c1[nH]ccs1)c1ccco1](/scaffold/FWBKTKWUXLKDLK-UHFFFAOYSA-N/structure.svg)
O=C(N=c1[nH]ccs1)c1ccco118 chemicals
O=C(Nc1nccs1)c1cccs115 chemicals
O=C(Nc1cccs1)c1ccco113 chemicals
C1CCP(CCP2CCCC2)C111 chemicals![Scaffold O=C(Nc1nccs1)c1ccn[nH]1](/scaffold/UPEJASJLMROVAC-UHFFFAOYSA-N/structure.svg)
O=C(Nc1nccs1)c1ccn[nH]19 chemicals
O=C(Nc1nncs1)c1ccco18 chemicals
O=C(Nc1nccs1)c1cnoc17 chemicals
O=C(NC1CCS(=O)(=O)C1)c1ccco16 chemicals![Scaffold O=C(NC1CCCC1)c1cc[nH]n1](/scaffold/ZXIHJQULADWRTI-UHFFFAOYSA-N/structure.svg)
O=C(NC1CCCC1)c1cc[nH]n16 chemicals
C(=Cc1ccco1)c1ccco14 chemicals
O=C(Nc1nncs1)C1CCCO14 chemicals
O=C(Nc1nncs1)C1CCCC14 chemicals