Murcko scaffold
Ring system with 2 rings and 13 atoms
58 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 13
- Chemicals
- 58
- With full pages
- 13
Scaffold SMILES
O=C(Nc1cccs1)c1ccco1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 58 chemicals
N-(3-Cyano-4,5-dimethylthiophen-2-yl)furan-2-carboxamide
CAS 331255-43-7C12H10N2O2S
Ethyl 2-(2-furamido)-4,5-dimethyl-3-thiophenecarboxylate
CAS 299199-69-2C14H15NO4S
5-Bromo-N-(3-cyano-4,5-dimethylthiophen-2-yl)furan-2-carboxamide
CAS 329221-31-0C12H9BrN2O2S
N-(3-Carbamoyl-4,5-dimethylthiophen-2-yl)furan-2-carboxamide
CAS 329221-75-2C12H12N2O3S
N-(4,5-Dimethylthiophen-2-yl)furan-2-carboxamide
CAS 622791-40-6C11H11NO2S
![Ethyl 5-acetyl-4-methyl-2-[(5-methyl-2-furoyl)amino]-3-thiophenecarboxylate chemical structure, C16H17NO5S, CAS 353476-40-1](/s/LMWBOQAJMOUWDW-UHFFFAOYSA-N.svg)
Ethyl 5-acetyl-4-methyl-2-[(5-methyl-2-furoyl)amino]-3-thiophenecarboxylate
CAS 353476-40-1C16H17NO5S
Ethyl 5-ethyl-2-(furan-2-carboxamido)thiophene-3-carboxylate
CAS 312528-68-0C14H15NO4S
Ethyl 5-ethyl-2-(furan-2-carboxamido)-4-methylthiophene-3-carboxylate
CAS 333359-08-3C15H17NO4S
Propan-2-yl 2-(furan-2-carbonylamino)-4,5-dimethylthiophene-3-carboxylate
CAS 444934-74-1C15H17NO4S
![Ethyl 5-methyl-2-[(5-methylfuran-2-carbonyl)amino]thiophene-3-carboxylate chemical structure, C14H15NO4S, CAS 444934-98-9](/s/ATWWSQUNNVPQIM-UHFFFAOYSA-N.svg)
Ethyl 5-methyl-2-[(5-methylfuran-2-carbonyl)amino]thiophene-3-carboxylate
CAS 444934-98-9C14H15NO4S
Ethyl 4-cyano-5-(2-furoylamino)-3-methylthiophene-2-carboxylate
CAS 443122-53-0C14H12N2O4S
![Ethyl 5-isopropyl-2-[(5-methyl-2-furoyl)amino]thiophene-3-carboxylate chemical structure, C16H19NO4S, CAS 445017-43-6](/s/BYQHQVMVZUAMLN-UHFFFAOYSA-N.svg)
Ethyl 5-isopropyl-2-[(5-methyl-2-furoyl)amino]thiophene-3-carboxylate
CAS 445017-43-6C16H19NO4S
4-Ethyl 2-methyl 5-(2-furoylamino)-3-methyl-2,4-thiophenedicarboxylate
CAS 433688-47-2C15H15NO6S
Dimethyl 5-(furan-2-carbonylamino)-3-methylthiophene-2,4-dicarboxylate
CAS 544657-89-8C14H13NO6S
N-(3-Carbamoyl-4,5-dimethylthiophen-2-yl)-5-methylfuran-2-carboxamide
CAS 560103-47-1C13H14N2O3S
N-(3-Carbamoyl-4-ethyl-5-methylthiophen-2-yl)-5-methylfuran-2-carboxamide
CAS 544669-77-4C14H16N2O3S
Propan-2-yl 4-ethyl-2-(furan-2-carbonylamino)-5-methylthiophene-3-carboxylate
CAS 540520-81-8C16H19NO4S
![Isopropyl 4,5-dimethyl-2-[(5-methyl-2-furoyl)amino]-3-thiophenecarboxylate chemical structure, C16H19NO4S, CAS 352677-08-8](/s/ZUROJBOBKFUNDZ-UHFFFAOYSA-N.svg)
Isopropyl 4,5-dimethyl-2-[(5-methyl-2-furoyl)amino]-3-thiophenecarboxylate
CAS 352677-08-8C16H19NO4S
![Ethyl 4-ethyl-5-methyl-2-[(5-methyl-2-furoyl)amino]-3-thiophenecarboxylate chemical structure, C16H19NO4S, CAS 352699-92-4](/s/FSRNOYXUUULAQA-UHFFFAOYSA-N.svg)
Ethyl 4-ethyl-5-methyl-2-[(5-methyl-2-furoyl)amino]-3-thiophenecarboxylate
CAS 352699-92-4C16H19NO4S
![Ethyl 2-[(5-bromofuran-2-carbonyl)amino]-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate chemical structure, C18H21BrN2O5S, CAS 544667-80-3](/s/YDSRBKFFMAYOMR-UHFFFAOYSA-N.svg)
Ethyl 2-[(5-bromofuran-2-carbonyl)amino]-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate
CAS 544667-80-3C18H21BrN2O5S
![Ethyl 5-[(dimethylamino)carbonyl]-2-(2-furoylamino)-4-methyl-3-thiophenecarboxylate chemical structure, C16H18N2O5S, CAS 547706-80-9](/s/CNQYZQGXBZISPE-UHFFFAOYSA-N.svg)
Ethyl 5-[(dimethylamino)carbonyl]-2-(2-furoylamino)-4-methyl-3-thiophenecarboxylate
CAS 547706-80-9C16H18N2O5S
![2-tert-Butyl 4-ethyl 5-[(5-bromo-2-furoyl)amino]-3-methyl-2,4-thiophenedicarboxylate chemical structure, C18H20BrNO6S, CAS 546100-36-1](/s/GVILCEOKMBSHFR-UHFFFAOYSA-N.svg)
2-tert-Butyl 4-ethyl 5-[(5-bromo-2-furoyl)amino]-3-methyl-2,4-thiophenedicarboxylate
CAS 546100-36-1C18H20BrNO6S
![Isopropyl 2-[(5-bromo-2-furoyl)amino]-4,5-dimethyl-3-thiophenecarboxylate chemical structure, C15H16BrNO4S, CAS 332874-29-0](/s/SFHFUCIUVDJLJW-UHFFFAOYSA-N.svg)
Isopropyl 2-[(5-bromo-2-furoyl)amino]-4,5-dimethyl-3-thiophenecarboxylate
CAS 332874-29-0C15H16BrNO4S
![Ethyl 5-(diethylcarbamoyl)-4-methyl-2-[(5-methylfuran-2-carbonyl)amino]thiophene-3-carboxylate chemical structure, C19H24N2O5S, CAS 544426-80-4](/s/ATZOHCNFLOCYBS-UHFFFAOYSA-N.svg)
Ethyl 5-(diethylcarbamoyl)-4-methyl-2-[(5-methylfuran-2-carbonyl)amino]thiophene-3-carboxylate
CAS 544426-80-4C19H24N2O5S
- Ethyl 2-[(5-bromofuran-2-carbonyl)amino]-4-ethyl-5-methylthiophene-3-carboxylate544424-82-0C15H16BrNO4S
- Ethyl 2-[(5-bromo-2-furoyl)amino]-4-isobutyl-3-thiophenecarboxylate326036-80-0C16H18BrNO4S
- Ethyl 5-acetyl-2-[(5-bromofuran-2-carbonyl)amino]-4-methylthiophene-3-carboxylate353468-20-9C15H14BrNO5S
- Diisopropyl 5-[(5-bromo-2-furoyl)amino]-3-methyl-2,4-thiophenedicarboxylate353782-20-4C18H20BrNO6S
- Isopropyl 5-[(diethylamino)carbonyl]-2-(2-furoylamino)-4-methyl-3-thiophenecarboxylate419558-00-2C19H24N2O5S
- Dimethyl 5-[(5-bromofuran-2-carbonyl)amino]-3-methylthiophene-2,4-dicarboxylate352676-74-5C14H12BrNO6S
- Ethyl 5-(diethylcarbamoyl)-2-(furan-2-carbonylamino)-4-methylthiophene-3-carboxylate352688-04-1C18H22N2O5S
- Ethyl 2-[(5-bromofuran-2-carbonyl)amino]-5-carbamoyl-4-methylthiophene-3-carboxylate352693-01-7C14H13BrN2O5S
- 4-O-Ethyl 2-O-methyl 5-[(5-bromofuran-2-carbonyl)amino]-3-methylthiophene-2,4-dicarboxylate433693-74-4C15H14BrNO6S
- 2-O-Methyl 4-O-propyl 3-methyl-5-[(5-methylfuran-2-carbonyl)amino]thiophene-2,4-dicarboxylate445021-50-1C17H19NO6S
- Propan-2-yl 4-carbamoyl-3-methyl-5-[(5-methylfuran-2-carbonyl)amino]thiophene-2-carboxylate339361-71-6C16H18N2O5S
- Ethyl 2-[(5-bromo-2-furoyl)amino]-4,5-dimethyl-3-thiophenecarboxylate352668-44-1C14H14BrNO4S
- Diethyl 5-({5-nitro-2-furoyl}amino)-3-methyl-2,4-thiophenedicarboxylate462097-78-5C16H16N2O8S
- Methyl 2-(furan-2-carboxamido)thiophene-3-carboxylate271778-22-4C11H9NO4S
- 2-(2-Furylcarbonylamino)-4,5-dimethylthiophene-3-carboxylic acid461430-85-3C12H11NO4S
- N-(3-Carbamoylthiophen-2-yl)furan-2-carboxamide58979-92-3C10H8N2O3S
- Methyl 5-{[(5-bromofuran-2-yl)carbonyl]amino}-4-cyano-3-methylthiophene-2-carboxylate461417-22-1C13H9BrN2O4S
- Ethyl 5-nitro-2-[(5-nitrofuran-2-carbonyl)amino]thiophene-3-carboxylate477491-13-7C12H9N3O8S
- 1 suppliersCbr-5884681159-27-3C14H12N2O4S2
- N-(3-Carbamoylthiophen-2-yl)-5-nitrofuran-2-carboxamide848179-97-5C10H7N3O5S
- Ethyl 3-methyl-5-(5-nitrofuran-2-carboxamido)thiophene-2-carboxylate477579-00-3C13H12N2O6S
- Ethyl 2-(furan-2-amido)thiophene-3-carboxylate864940-48-7C12H11NO4S
- N-[3-(Methylcarbamoyl)thiophen-2-yl]-5-nitrofuran-2-carboxamide941871-28-9C11H9N3O5S
- N-(3-Cyanothiophen-2-yl)-5-nitrofuran-2-carboxamide908502-62-5C10H5N3O4S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(N=c1[nH]ccs1)c1ccco1](/scaffold/FWBKTKWUXLKDLK-UHFFFAOYSA-N/structure.svg)
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O=C(Nc1nccs1)c1ccn[nH]19 chemicals
O=C(Nc1nncs1)c1ccco18 chemicals
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O=C(NC1CCS(=O)(=O)C1)c1ccco16 chemicals![Scaffold O=C(NC1CCCC1)c1cc[nH]n1](/scaffold/ZXIHJQULADWRTI-UHFFFAOYSA-N/structure.svg)
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