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Murcko scaffold

4-Phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one scaffold

17 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
17
With full pages
1
Scaffold SMILES

O=C1CC(c2ccccc2)Nc2ccccc2N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-Phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one page
Murcko scaffold O=C1CC(c2ccccc2)Nc2ccccc2N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

5-(3-Chloropropanoyl)-4-phenyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one chemical structure, C18H17ClN2O2, CAS 73416-95-2
5-(3-Chloropropanoyl)-4-phenyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one
CAS 73416-95-2C18H17ClN2O2
4-Phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one chemical structure, C15H14N2O, CAS 16442-58-3
4-Phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one
CAS 16442-58-3C15H14N2O
4-(p-Tolyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one chemical structure, C16H16N2O, CAS 881901-98-0
4-(p-Tolyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one
CAS 881901-98-0C16H16N2O
4-(4-Chlorophenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one chemical structure, C15H13ClN2O, CAS 881901-99-1
4-(4-Chlorophenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one
CAS 881901-99-1C15H13ClN2O
4-(4-Bromophenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one chemical structure, C15H13BrN2O, CAS 2173253-14-8
4-(4-Bromophenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one
CAS 2173253-14-8C15H13BrN2O
4-(4-Methoxyphenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one chemical structure, C16H16N2O2, CAS 92966-22-8
4-(4-Methoxyphenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one
CAS 92966-22-8C16H16N2O2
4-(3-Methoxyphenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one chemical structure, C16H16N2O2, CAS 2173253-11-5
4-(3-Methoxyphenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one
CAS 2173253-11-5C16H16N2O2
4-(2-Bromo-5-methoxyphenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one chemical structure, C16H15BrN2O2, CAS 2173253-12-6
4-(2-Bromo-5-methoxyphenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one
CAS 2173253-12-6C16H15BrN2O2
4-(4-(Trifluoromethyl)phenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one chemical structure, C16H13F3N2O, CAS 2173253-15-9
4-(4-(Trifluoromethyl)phenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one
CAS 2173253-15-9C16H13F3N2O
4-(3-Bromo-4-methoxyphenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one chemical structure, C16H15BrN2O2, CAS 2173253-16-0
4-(3-Bromo-4-methoxyphenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one
CAS 2173253-16-0C16H15BrN2O2
4-(3-Chlorophenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one chemical structure, C15H13ClN2O, CAS 2173253-09-1
4-(3-Chlorophenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one
CAS 2173253-09-1C15H13ClN2O
4-(m-Tolyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one chemical structure, C16H16N2O, CAS 2173253-10-4
4-(m-Tolyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one
CAS 2173253-10-4C16H16N2O
4-(5-Bromo-2-methoxyphenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one chemical structure, C16H15BrN2O2, CAS 2173253-07-9
4-(5-Bromo-2-methoxyphenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one
CAS 2173253-07-9C16H15BrN2O2
4-(2-Methoxyphenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one chemical structure, C16H16N2O2, CAS 2173253-06-8
4-(2-Methoxyphenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one
CAS 2173253-06-8C16H16N2O2
4-(4-Fluorophenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one chemical structure, C15H13FN2O, CAS 2173253-13-7
4-(4-Fluorophenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one
CAS 2173253-13-7C15H13FN2O
4-(2-Fluorophenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one chemical structure, C15H13FN2O, CAS 2173253-05-7
4-(2-Fluorophenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one
CAS 2173253-05-7C15H13FN2O
4-(3-Fluorophenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one chemical structure, C15H13FN2O, CAS 2173253-08-0
4-(3-Fluorophenyl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one
CAS 2173253-08-0C15H13FN2O