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Murcko scaffold

1,3-Dihydro-4-phenyl-2H-1,5-benzodiazepin-2-one scaffold

25 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
25
With full pages
8
Scaffold SMILES

O=C1CC(c2ccccc2)=Nc2ccccc2N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,3-Dihydro-4-phenyl-2H-1,5-benzodiazepin-2-one page
Murcko scaffold O=C1CC(c2ccccc2)=Nc2ccccc2N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 25 of 25 chemicals

1,3-Dihydro-4-phenyl-2H-1,5-benzodiazepin-2-one chemical structure, C15H12N2O, CAS 16439-95-5
1,3-Dihydro-4-phenyl-2H-1,5-benzodiazepin-2-one
CAS 16439-95-5C15H12N2O
7,8-Dimethyl-4-phenyl-1,3-dihydro-2H-1,5-benzodiazepin-2-one chemical structure, C17H16N2O, CAS 82259-42-5
7,8-Dimethyl-4-phenyl-1,3-dihydro-2H-1,5-benzodiazepin-2-one
CAS 82259-42-5C17H16N2O
8-Methyl-4-phenyl-1,3-dihydro-2H-1,5-benzodiazepin-2-one chemical structure, C16H14N2O, CAS 64376-00-7
8-Methyl-4-phenyl-1,3-dihydro-2H-1,5-benzodiazepin-2-one
CAS 64376-00-7C16H14N2O
4-(4-Methoxyphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one chemical structure, C16H14N2O2, CAS 71200-91-4
4-(4-Methoxyphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one
CAS 71200-91-4C16H14N2O2
4-(4-Chlorophenyl)-1,3-dihydro-1,5-benzodiazepin-2-one chemical structure, C15H11ClN2O, CAS 82040-00-4
4-(4-Chlorophenyl)-1,3-dihydro-1,5-benzodiazepin-2-one
CAS 82040-00-4C15H11ClN2O
2H-1,5-Benzodiazepin-2-one, 8-bromo-1,3-dihydro-4-phenyl- chemical structure, C15H11BrN2O, CAS 66752-07-6
2H-1,5-Benzodiazepin-2-one, 8-bromo-1,3-dihydro-4-phenyl-
CAS 66752-07-6C15H11BrN2O
2H-1,5-Benzodiazepin-2-one, 1,3-dihydro-1-(3-(dimethylamino)propyl)-4-phenyl- chemical structure, C20H23N3O, CAS 126568-02-3
2H-1,5-Benzodiazepin-2-one, 1,3-dihydro-1-(3-(dimethylamino)propyl)-4-phenyl-
CAS 126568-02-3C20H23N3O
2H-1,5-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-1-(2-(dimethylamino)ethyl)-4-phenyl- chemical structure, C19H20ClN3O, CAS 126568-04-5
2H-1,5-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-1-(2-(dimethylamino)ethyl)-4-phenyl-
CAS 126568-04-5C19H20ClN3O
2H-1,5-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-1-(3-(dimethylamino)propyl)-4-phenyl- chemical structure, C20H22ClN3O, CAS 126568-05-6
2H-1,5-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-1-(3-(dimethylamino)propyl)-4-phenyl-
CAS 126568-05-6C20H22ClN3O
3-Bromo-4-phenyl-1,3-dihydro-2H-1,5-benzodiazepin-2-one chemical structure, C15H11BrN2O, CAS 66752-03-2
3-Bromo-4-phenyl-1,3-dihydro-2H-1,5-benzodiazepin-2-one
CAS 66752-03-2C15H11BrN2O
1,3-Dihydro-4-(5-fluoro-2-hydroxyphenyl)-2H-1,5-benzodiazepin-2-one chemical structure, C15H11FN2O2, CAS 351003-09-3
1,3-Dihydro-4-(5-fluoro-2-hydroxyphenyl)-2H-1,5-benzodiazepin-2-one
CAS 351003-09-3C15H11FN2O2
2H-1,5-Benzodiazepin-2-one, 8-chloro-1,3-dihydro-4-phenyl- chemical structure, C15H11ClN2O, CAS 64375-99-1
2H-1,5-Benzodiazepin-2-one, 8-chloro-1,3-dihydro-4-phenyl-
CAS 64375-99-1C15H11ClN2O
1,3-Dihydro-4-(2-hydroxyphenyl)-2H-1,5-benzodiazepin-2-one chemical structure, C15H12N2O2, CAS 61487-06-7
1,3-Dihydro-4-(2-hydroxyphenyl)-2H-1,5-benzodiazepin-2-one
CAS 61487-06-7C15H12N2O2
4-(5-Bromo-2-hydroxyphenyl)-1,3-dihydro-2H-1,5-benzodiazepin-2-one chemical structure, C15H11BrN2O2, CAS 351003-29-7
4-(5-Bromo-2-hydroxyphenyl)-1,3-dihydro-2H-1,5-benzodiazepin-2-one
CAS 351003-29-7C15H11BrN2O2
2H-1,5-Benzodiazepin-2-one, 1,3-dihydro-1-methyl-4-phenyl- chemical structure, C16H14N2O, CAS 58876-61-2
2H-1,5-Benzodiazepin-2-one, 1,3-dihydro-1-methyl-4-phenyl-
CAS 58876-61-2C16H14N2O
1-Ethyl-4-phenyl-3H-1,5-benzodiazepin-2-one chemical structure, C17H16N2O, CAS 78662-07-4
1-Ethyl-4-phenyl-3H-1,5-benzodiazepin-2-one
CAS 78662-07-4C17H16N2O
7-Amino-4-phenyl-1,3-dihydro-2H-1,5-benzodiazepin-2-one chemical structure, C15H13N3O, CAS 63614-63-1
7-Amino-4-phenyl-1,3-dihydro-2H-1,5-benzodiazepin-2-one
CAS 63614-63-1C15H13N3O
1,3-Dihydro-1-nitroso-4-phenyl-2H-1,5-benzodiazepin-2-one chemical structure, C15H11N3O2, CAS 101947-19-7
1,3-Dihydro-1-nitroso-4-phenyl-2H-1,5-benzodiazepin-2-one
CAS 101947-19-7C15H11N3O2
1,3-Dimethyl-4-phenyl-1,3-dihydro-2H-1,5-benzodiazepin-2-one chemical structure, C17H16N2O, CAS 143206-49-9
1,3-Dimethyl-4-phenyl-1,3-dihydro-2H-1,5-benzodiazepin-2-one
CAS 143206-49-9C17H16N2O
3-(7-Iodo-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-benzonitrile chemical structure, C16H10IN3O, CAS 335257-47-1
3-(7-Iodo-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-benzonitrile
CAS 335257-47-1C16H10IN3O
7,8-Dimethyl-4-(p-tolyl)-1H-benzo[b][1,4]diazepin-2(3H)-one chemical structure, C18H18N2O, CAS 1019176-68-1
7,8-Dimethyl-4-(p-tolyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
CAS 1019176-68-1C18H18N2O
4-(3,4-Dimethylphenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one chemical structure, C17H16N2O, CAS 1092284-67-7
4-(3,4-Dimethylphenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
CAS 1092284-67-7C17H16N2O
4-(4-Fluorophenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one chemical structure, C15H11FN2O, CAS 1031629-33-0
4-(4-Fluorophenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
CAS 1031629-33-0C15H11FN2O
(E)-4-(5-Chloro-2-hydroxyphenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one chemical structure, C15H11ClN2O2, CAS 352667-35-7
(E)-4-(5-Chloro-2-hydroxyphenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
CAS 352667-35-7C15H11ClN2O2