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Murcko scaffold

Ring system with 3 rings and 18 atoms

91 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
91
With full pages
1
Scaffold SMILES

O=C1COc2ccccc2CN1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1COc2ccccc2CN1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 91 chemicals

4-(4-Chlorophenyl)-4,5-dihydro-1,4-benzoxazepin-3(2H)-one chemical structure, C15H12ClNO2, CAS 7034-29-9
4-(4-Chlorophenyl)-4,5-dihydro-1,4-benzoxazepin-3(2H)-one
CAS 7034-29-9C15H12ClNO2
2-Methyl-4-(4-methylphenyl)-5H-1,4-benzoxazepin-3-one chemical structure, C17H17NO2, CAS 682346-43-6
2-Methyl-4-(4-methylphenyl)-5H-1,4-benzoxazepin-3-one
CAS 682346-43-6C17H17NO2
7-Chloro-4-phenyl-4,5-dihydro-1,4-benzoxazepin-3(2H)-one chemical structure, C15H12ClNO2, CAS 7082-53-3
7-Chloro-4-phenyl-4,5-dihydro-1,4-benzoxazepin-3(2H)-one
CAS 7082-53-3C15H12ClNO2
7-Chloro-4-(4-methylphenyl)-4,5-dihydro-1,4-benzoxazepin-3(2H)-one chemical structure, C16H14ClNO2, CAS 950277-71-1
7-Chloro-4-(4-methylphenyl)-4,5-dihydro-1,4-benzoxazepin-3(2H)-one
CAS 950277-71-1C16H14ClNO2
Methyl 4-(4-fluorophenyl)-3-oxo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine-7-carboxylate chemical structure, C17H14FNO4, CAS 950266-79-2
Methyl 4-(4-fluorophenyl)-3-oxo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine-7-carboxylate
CAS 950266-79-2C17H14FNO4
7-Chloro-4-(3-ethylphenyl)-2,3,4,5-tetrahydro-1,4-benzoxazepin-3-one chemical structure, C17H16ClNO2, CAS 950277-77-7
7-Chloro-4-(3-ethylphenyl)-2,3,4,5-tetrahydro-1,4-benzoxazepin-3-one
CAS 950277-77-7C17H16ClNO2
4-(7-Chloro-3-oxo-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl)benzoic acid chemical structure, C16H12ClNO4, CAS 950266-82-7
4-(7-Chloro-3-oxo-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl)benzoic acid
CAS 950266-82-7C16H12ClNO4
Methyl 4-(7-chloro-3-oxo-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl)benzoate chemical structure, C17H14ClNO4, CAS 1031976-91-6
Methyl 4-(7-chloro-3-oxo-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl)benzoate
CAS 1031976-91-6C17H14ClNO4
3-(2-Methyl-3-oxo-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl)benzonitrile chemical structure, C17H14N2O2, CAS 1340712-33-5
3-(2-Methyl-3-oxo-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl)benzonitrile
CAS 1340712-33-5C17H14N2O2
4-(2-Methyl-3-oxo-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl)benzonitrile chemical structure, C17H14N2O2, CAS 1340697-88-2
4-(2-Methyl-3-oxo-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl)benzonitrile
CAS 1340697-88-2C17H14N2O2
4-(4-Methylphenyl)-4,5-dihydro-1,4-benzoxazepin-3(2H)-one chemical structure, C16H15NO2, CAS 99779-33-6
4-(4-Methylphenyl)-4,5-dihydro-1,4-benzoxazepin-3(2H)-one
CAS 99779-33-6C16H15NO2
4-(3,4-Dimethylphenyl)-4,5-dihydrobenzo[f][1,4]oxazepin-3(2H)-one chemical structure, C17H17NO2, CAS 1359596-54-5
4-(3,4-Dimethylphenyl)-4,5-dihydrobenzo[f][1,4]oxazepin-3(2H)-one
CAS 1359596-54-5C17H17NO2
4-(3-Ethylphenyl)-4,5-dihydro-1,4-benzoxazepin-3(2H)-one chemical structure, C17H17NO2, CAS 1357778-19-8
4-(3-Ethylphenyl)-4,5-dihydro-1,4-benzoxazepin-3(2H)-one
CAS 1357778-19-8C17H17NO2
4-(4-Ethoxyphenyl)-4,5-dihydro-1,4-benzoxazepin-3(2H)-one chemical structure, C17H17NO3, CAS 1359621-86-5
4-(4-Ethoxyphenyl)-4,5-dihydro-1,4-benzoxazepin-3(2H)-one
CAS 1359621-86-5C17H17NO3
4-[3-(Methylthio)phenyl]-4,5-dihydro-1,4-benzoxazepin-3(2H)-one chemical structure, C16H15NO2S, CAS 1358242-97-3
4-[3-(Methylthio)phenyl]-4,5-dihydro-1,4-benzoxazepin-3(2H)-one
CAS 1358242-97-3C16H15NO2S
4-(3-Oxo-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl)benzonitrile chemical structure, C16H12N2O2, CAS 1326871-38-8
4-(3-Oxo-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl)benzonitrile
CAS 1326871-38-8C16H12N2O2
Methyl 4-(3-oxo-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl)benzoate chemical structure, C17H15NO4, CAS 1359596-64-7
Methyl 4-(3-oxo-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl)benzoate
CAS 1359596-64-7C17H15NO4
4-(3-Bromophenyl)-4,5-dihydro-1,4-benzoxazepin-3(2H)-one chemical structure, C15H12BrNO2, CAS 1358096-11-3
4-(3-Bromophenyl)-4,5-dihydro-1,4-benzoxazepin-3(2H)-one
CAS 1358096-11-3C15H12BrNO2
4-(4-Bromophenyl)-4,5-dihydro-1,4-benzoxazepin-3(2H)-one chemical structure, C15H12BrNO2, CAS 1222170-16-2
4-(4-Bromophenyl)-4,5-dihydro-1,4-benzoxazepin-3(2H)-one
CAS 1222170-16-2C15H12BrNO2
4-(3-Chloro-4-fluorophenyl)-4,5-dihydro-1,4-benzoxazepin-3(2H)-one chemical structure, C15H11ClFNO2, CAS 1357962-39-0
4-(3-Chloro-4-fluorophenyl)-4,5-dihydro-1,4-benzoxazepin-3(2H)-one
CAS 1357962-39-0C15H11ClFNO2
4-[3-(Trifluoromethyl)phenyl]-4,5-dihydro-1,4-benzoxazepin-3(2H)-one chemical structure, C16H12F3NO2, CAS 1222170-19-5
4-[3-(Trifluoromethyl)phenyl]-4,5-dihydro-1,4-benzoxazepin-3(2H)-one
CAS 1222170-19-5C16H12F3NO2
4-[3-(Trifluoromethoxy)phenyl]-4,5-dihydro-1,4-benzoxazepin-3(2H)-one chemical structure, C16H12F3NO3, CAS 1358243-16-9
4-[3-(Trifluoromethoxy)phenyl]-4,5-dihydro-1,4-benzoxazepin-3(2H)-one
CAS 1358243-16-9C16H12F3NO3
4-(3-Fluoro-4-methylphenyl)-4,5-dihydro-1,4-benzoxazepin-3(2H)-one chemical structure, C16H14FNO2, CAS 1359410-68-6
4-(3-Fluoro-4-methylphenyl)-4,5-dihydro-1,4-benzoxazepin-3(2H)-one
CAS 1359410-68-6C16H14FNO2
4-(4-Fluoro-3-methylphenyl)-4,5-dihydro-1,4-benzoxazepin-3(2H)-one chemical structure, C16H14FNO2, CAS 1326851-63-1
4-(4-Fluoro-3-methylphenyl)-4,5-dihydro-1,4-benzoxazepin-3(2H)-one
CAS 1326851-63-1C16H14FNO2