Murcko scaffold
Ring system with 4 rings and 26 atoms
95 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 26
- Chemicals
- 95
- With full pages
- 4
Scaffold SMILES
O=C1C(=O)N(c2ccccn2)C(c2ccccc2)C1=Cc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 95 chemicals
![4-[(4-Chlorophenyl)-hydroxymethylidene]-5-(4-methoxyphenyl)-1-pyridin-2-ylpyrrolidine-2,3-dione chemical structure, C23H17ClN2O4](/s/JMNGTPFRLYFODB-UHFFFAOYSA-N.svg)
4-[(4-Chlorophenyl)-hydroxymethylidene]-5-(4-methoxyphenyl)-1-pyridin-2-ylpyrrolidine-2,3-dione
C23H17ClN2O4
4-(4-Chlorobenzoyl)-5-(3-chlorophenyl)-3-hydroxy-1-(pyridin-2-yl)-2,5-dihydro-1H-pyrrol-2-one
C22H14Cl2N2O3
5-(3,4-Dimethoxyphenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-(pyridin-2-yl)-2,5-dihydro-1H-pyrrol-2-one
C25H22N2O6
![4-[2-(4-Fluorophenyl)-4-hydroxy-1-(6-methylpyridin-2-yl)-5-oxo-2,5-dihydro-1H-pyrrole-3-carbonyl]-N,N-dimethylbenzene-1-sulfonamide chemical structure, C25H22FN3O5S](/s/HGWJFEWQQPZEIJ-UHFFFAOYSA-N.svg)
4-[2-(4-Fluorophenyl)-4-hydroxy-1-(6-methylpyridin-2-yl)-5-oxo-2,5-dihydro-1H-pyrrole-3-carbonyl]-N,N-dimethylbenzene-1-sulfonamide
C25H22FN3O5S
![5-(3-Bromophenyl)-4-[hydroxy(3-methoxyphenyl)methylene]-1-(2-pyridinyl)-2,3-pyrrolidinedione chemical structure, C23H17BrN2O4, CAS 898795-96-5](/s/MZBCHGXGTFFQJU-UHFFFAOYSA-N.svg)
5-(3-Bromophenyl)-4-[hydroxy(3-methoxyphenyl)methylene]-1-(2-pyridinyl)-2,3-pyrrolidinedione
CAS 898795-96-5C23H17BrN2O4
3-Hydroxy-4-(4-methoxybenzoyl)-5-(4-methoxyphenyl)-1-(pyridin-2-yl)-2,5-dihydro-1H-pyrrol-2-one
C24H20N2O5
5-(4-Fluorophenyl)-3-hydroxy-4-(3-methyl-4-propoxybenzoyl)-1-(pyridin-2-yl)-2,5-dihydro-1H-pyrrol-2-one
C26H23FN2O4
5-(4-Chlorophenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-(pyridin-2-yl)-2,5-dihydro-1H-pyrrol-2-one
C23H17ClN2O4
![5-(2-Fluorophenyl)-4-[hydroxy-(3-methyl-4-propoxyphenyl)methylidene]-1-pyridin-2-ylpyrrolidine-2,3-dione chemical structure, C26H23FN2O4](/s/VRDCNAZRAJHMSS-UHFFFAOYSA-N.svg)
5-(2-Fluorophenyl)-4-[hydroxy-(3-methyl-4-propoxyphenyl)methylidene]-1-pyridin-2-ylpyrrolidine-2,3-dione
C26H23FN2O4
![4-[(4-Ethoxy-2-methylphenyl)-hydroxymethylidene]-5-(4-methylphenyl)-1-pyridin-2-ylpyrrolidine-2,3-dione chemical structure, C26H24N2O4](/s/IXEFAGJAOSYQLD-UHFFFAOYSA-N.svg)
4-[(4-Ethoxy-2-methylphenyl)-hydroxymethylidene]-5-(4-methylphenyl)-1-pyridin-2-ylpyrrolidine-2,3-dione
C26H24N2O4
![5-(4-tert-Butylphenyl)-4-[hydroxy-(3-methyl-4-propoxyphenyl)methylidene]-1-pyridin-2-ylpyrrolidine-2,3-dione chemical structure, C30H32N2O4](/s/IMWYZPWQNWTNED-UHFFFAOYSA-N.svg)
5-(4-tert-Butylphenyl)-4-[hydroxy-(3-methyl-4-propoxyphenyl)methylidene]-1-pyridin-2-ylpyrrolidine-2,3-dione
C30H32N2O4
![5-(4-tert-Butylphenyl)-4-[hydroxy-(3-methoxyphenyl)methylidene]-1-pyridin-2-ylpyrrolidine-2,3-dione chemical structure, C27H26N2O4, CAS 4858-89-3](/s/ILMUDAQOQIFPLP-UHFFFAOYSA-N.svg)
5-(4-tert-Butylphenyl)-4-[hydroxy-(3-methoxyphenyl)methylidene]-1-pyridin-2-ylpyrrolidine-2,3-dione
CAS 4858-89-3C27H26N2O4
![3-Hydroxy-5-(4-methoxyphenyl)-4-[(4-methylphenyl)carbonyl]-1-(pyridin-2-yl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C24H20N2O4, CAS 307541-83-9](/s/RPXIIBIBFKRSMH-LSDHQDQOSA-N.svg)
3-Hydroxy-5-(4-methoxyphenyl)-4-[(4-methylphenyl)carbonyl]-1-(pyridin-2-yl)-1,5-dihydro-2H-pyrrol-2-one
CAS 307541-83-9C24H20N2O4
5-(4-Fluorophenyl)-3-hydroxy-4-(4-methylbenzoyl)-1-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 307541-81-7C23H17FN2O3
![(4E)-5-(4-Bromophenyl)-4-[(4-chlorophenyl)-hydroxymethylidene]-1-pyridin-2-ylpyrrolidine-2,3-dione chemical structure, C22H14BrClN2O3, CAS 5786-34-5](/s/BCIWBMITIVDPMM-CZIZESTLSA-N.svg)
(4E)-5-(4-Bromophenyl)-4-[(4-chlorophenyl)-hydroxymethylidene]-1-pyridin-2-ylpyrrolidine-2,3-dione
CAS 5786-34-5C22H14BrClN2O3
5-(4-Chlorophenyl)-3-hydroxy-4-(phenylcarbonyl)-1-(pyridin-2-yl)-1,5-dihydro-2H-pyrrol-2-one
CAS 332022-56-7C22H15ClN2O3
4-Benzoyl-5-(4-fluorophenyl)-3-hydroxy-1-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 332022-55-6C22H15FN2O3
4-(4-Chlorobenzoyl)-3-hydroxy-5-(4-methoxyphenyl)-1-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
CAS 332022-47-6C23H17ClN2O4
methanolate chemical structure, C23H18N2O5, CAS 371118-66-0](/s/NWHLOWYQLORDAA-XUTLUUPISA-N.svg)
(E)-[2-(4-Hydroxy-3-methoxyphenyl)-4,5-dioxo-1-(pyridinium-2-yl)pyrrolidin-3-ylidene](phenyl)methanolate
CAS 371118-66-0C23H18N2O5
![(4Z)-4-[Hydroxy-(4-methylphenyl)methylidene]-5-(4-methoxyphenyl)-1-pyridin-2-ylpyrrolidine-2,3-dione chemical structure, C24H20N2O4, CAS 6195-98-8](/s/RPXIIBIBFKRSMH-XDOYNYLZSA-N.svg)
(4Z)-4-[Hydroxy-(4-methylphenyl)methylidene]-5-(4-methoxyphenyl)-1-pyridin-2-ylpyrrolidine-2,3-dione
CAS 6195-98-8C24H20N2O4
![(E)-(4-Chlorophenyl)[2-(3-chlorophenyl)-4,5-dioxo-1-(pyridinium-2-yl)pyrrolidin-3-ylidene]methanolate chemical structure, C22H14Cl2N2O3, CAS 6237-69-0](/s/ZWAAUTXRPQCQGQ-CZIZESTLSA-N.svg)
(E)-(4-Chlorophenyl)[2-(3-chlorophenyl)-4,5-dioxo-1-(pyridinium-2-yl)pyrrolidin-3-ylidene]methanolate
CAS 6237-69-0C22H14Cl2N2O3
4-Benzoyl-3-hydroxy-1-(6-methylpyridin-2-yl)-5-phenyl-1H-pyrrol-2(5H)-one
CAS 374098-55-2C23H18N2O3
![5-(3-Bromophenyl)-4-[(4-chlorophenyl)carbonyl]-3-hydroxy-1-(pyridin-2-yl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C22H14BrClN2O3, CAS 373373-97-8](/s/VKRRTFXDWNIFNB-CZIZESTLSA-N.svg)
5-(3-Bromophenyl)-4-[(4-chlorophenyl)carbonyl]-3-hydroxy-1-(pyridin-2-yl)-1,5-dihydro-2H-pyrrol-2-one
CAS 373373-97-8C22H14BrClN2O3
![5-(3,4-Dimethoxyphenyl)-4-[(4-fluorophenyl)carbonyl]-3-hydroxy-1-(pyridin-2-yl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C24H19FN2O5, CAS 374615-47-1](/s/JVVJNJZGGTXWBP-LSDHQDQOSA-N.svg)
5-(3,4-Dimethoxyphenyl)-4-[(4-fluorophenyl)carbonyl]-3-hydroxy-1-(pyridin-2-yl)-1,5-dihydro-2H-pyrrol-2-one
CAS 374615-47-1C24H19FN2O5
- 3-Hydroxy-4-(3-methoxybenzoyl)-5-(2-methoxyphenyl)-1-(pyridin-2-yl)-1H-pyrrol-2(5H)-one618418-26-1C24H20N2O5
- 5-(3,4-Dimethoxyphenyl)-3-hydroxy-4-(phenylcarbonyl)-1-(pyridin-2-yl)-1,5-dihydro-2H-pyrrol-2-one332022-52-3C24H20N2O5
- (E)-[2-(2-Nitrophenyl)-4,5-dioxo-1-(pyridinium-2-yl)pyrrolidin-3-ylidene](phenyl)methanolate332022-51-2C22H15N3O5
- 4-Benzoyl-3-hydroxy-5-(3-nitrophenyl)-1-(pyridin-2-yl)-1H-pyrrol-2(5H)-one332022-50-1C22H15N3O5
- (E)-(4-Methoxyphenyl)[2-(3-nitrophenyl)-4,5-dioxo-1-(pyridinium-2-yl)pyrrolidin-3-ylidene]methanolate380892-22-8C23H17N3O6
- (E)-(4-Methoxyphenyl)[2-(4-nitrophenyl)-4,5-dioxo-1-(pyridinium-2-yl)pyrrolidin-3-ylidene]methanolate378774-85-7C23H17N3O6
- (E)-[2-(3-Chlorophenyl)-4,5-dioxo-1-(pyridinium-2-yl)pyrrolidin-3-ylidene](4-methoxyphenyl)methanolate381691-63-0C23H17ClN2O4
- (4E)-5-(4-Bromophenyl)-4-{hydroxy[4-(propan-2-yloxy)phenyl]methylidene}-1-(pyridin-2-yl)pyrrolidine-2,3-dione371930-22-2C25H21BrN2O4
- (E)-[2-(3-Nitrophenyl)-4,5-dioxo-1-(pyridinium-2-yl)pyrrolidin-3-ylidene][4-(propan-2-yloxy)phenyl]methanolate371141-90-1C25H21N3O6
- 3-Hydroxy-5-phenyl-4-[4-(propan-2-yloxy)benzoyl]-1-(pyridin-2-yl)-2,5-dihydro-1H-pyrrol-2-one384375-11-5C25H22N2O4
- 3-Hydroxy-5-(3-methoxyphenyl)-4-[4-(propan-2-yloxy)benzoyl]-1-(pyridin-2-yl)-2,5-dihydro-1H-pyrrol-2-one384349-27-3C26H24N2O5
- (4E)-4-{Hydroxy[4-(propan-2-yloxy)phenyl]methylidene}-5-(4-nitrophenyl)-1-(pyridin-2-yl)pyrrolidine-2,3-dione371206-78-9C25H21N3O6
- 5-(3,4-Dimethoxyphenyl)-3-hydroxy-4-(4-propoxybenzoyl)-1-(2-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one615270-97-8C27H26N2O6
- 5-(3-Bromophenyl)-3-hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-1-(pyridin-2-yl)-2,5-dihydro-1H-pyrrol-2-one615272-23-6C25H19BrN2O4
- 5-(2-Fluorophenyl)-3-hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-1-(pyridin-2-yl)-2,5-dihydro-1H-pyrrol-2-one615272-22-5C25H19FN2O4
- 4-Benzoyl-5-(2-chlorophenyl)-3-hydroxy-1-(pyridin-2-yl)-2,5-dihydro-1H-pyrrol-2-one385391-37-7C22H15ClN2O3
- Methyl 4-[3-(4-fluorobenzoyl)-4-hydroxy-5-oxo-1-(pyridin-2-yl)-2,5-dihydro-1H-pyrrol-2-yl]benzoate462069-88-1C24H17FN2O5
- (4E)-4-[Hydroxy(3-methoxyphenyl)methylidene]-5-(3-nitrophenyl)-1-(pyridin-2-yl)pyrrolidine-2,3-dione618418-11-4C23H17N3O6
- (E)-(3-Chloro-4-methoxyphenyl)[2-(3-chlorophenyl)-4,5-dioxo-1-(pyridinium-2-yl)pyrrolidin-3-ylidene]methanolate638133-70-7C23H16Cl2N2O4
- (E)-(3-Chloro-4-methoxyphenyl)[2-(3-nitrophenyl)-4,5-dioxo-1-(pyridinium-2-yl)pyrrolidin-3-ylidene]methanolate638133-73-0C23H16ClN3O6
- (4Z)-4-[(4-Chlorophenyl)-hydroxymethylidene]-5-(4-methoxyphenyl)-1-pyridin-2-ylpyrrolidine-2,3-dioneC23H17ClN2O4
- 3-Hydroxy-4-(4-methylbenzoyl)-1-(pyridin-2-yl)-5-(p-tolyl)-1H-pyrrol-2(5H)-one307541-86-2C24H20N2O3
- 4-Benzoyl-5-(4-chlorophenyl)-3-hydroxy-1-(6-methyl-2-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one384369-78-2C23H17ClN2O3
- 5-(2-Chlorophenyl)-3-hydroxy-4-(4-methylbenzoyl)-1-(pyridin-2-yl)-1H-pyrrol-2(5H)-one307541-80-6C23H17ClN2O3
Related scaffolds
Same ring framework with different atoms or bond orders
O=S(=O)(c1ccccc1)c1cnn(-c2ccccc2)c1-c1ccccc14 chemicals
O=C1C(=O)N(c2ccccc2)C(c2ccccc2)C1=Cc1ccccc13 chemicals
O=C(c1ccccc1)c1cnn(-c2ccccc2)c1-c1ccccc12 chemicals
c1ccc(N=c2scc(-c3ccccc3)n2-c2ccccc2)cc11 chemical
c1ccc(Sc2nnc(-c3ccccc3)n2-c2ccccc2)cc11 chemical
c1ccc(Cn2ccc(-c3ccccc3)c2-c2ccccc2)cc11 chemical