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Murcko scaffold

Ring system with 4 rings and 26 atoms

113 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
113
With full pages
3
Scaffold SMILES

O=C1C(=O)N(c2ccccc2)C(c2ccccc2)C1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(=O)N(c2ccccc2)C(c2ccccc2)C1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 113 chemicals

2H-Pyrrol-2-one, 4-benzoyl-1,5-dihydro-3-hydroxy-1,5-diphenyl- chemical structure, C23H17NO3, CAS 108783-92-2
2H-Pyrrol-2-one, 4-benzoyl-1,5-dihydro-3-hydroxy-1,5-diphenyl-
CAS 108783-92-2C23H17NO3
4-Benzoyl-3-hydroxy-5-(4-nitrophenyl)-1-phenyl-1H-pyrrol-2(5H)-one chemical structure, C23H16N2O5, CAS 331751-17-8
4-Benzoyl-3-hydroxy-5-(4-nitrophenyl)-1-phenyl-1H-pyrrol-2(5H)-one
CAS 331751-17-8C23H16N2O5
5-(2-Fluorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-methoxyphenyl)pyrrolidine-2,3-dione chemical structure, C24H18FNO4, CAS 672266-29-4
5-(2-Fluorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-methoxyphenyl)pyrrolidine-2,3-dione
CAS 672266-29-4C24H18FNO4
5-(4-Bromophenyl)-1-(4-fluorophenyl)-4-[hydroxy-(4-methylphenyl)methylidene]pyrrolidine-2,3-dione chemical structure, C24H17BrFNO3
5-(4-Bromophenyl)-1-(4-fluorophenyl)-4-[hydroxy-(4-methylphenyl)methylidene]pyrrolidine-2,3-dione
C24H17BrFNO3
4-[Hydroxy(phenyl)methylidene]-1-(4-methylphenyl)-5-(3-nitrophenyl)pyrrolidine-2,3-dione chemical structure, C24H18N2O5, CAS 5694-29-1
4-[Hydroxy(phenyl)methylidene]-1-(4-methylphenyl)-5-(3-nitrophenyl)pyrrolidine-2,3-dione
CAS 5694-29-1C24H18N2O5
4-(4-Ethoxybenzoyl)-3-hydroxy-1,5-bis(4-methoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C27H25NO6, CAS 840483-89-8
4-(4-Ethoxybenzoyl)-3-hydroxy-1,5-bis(4-methoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 840483-89-8C27H25NO6
5-(3,4-Dimethoxyphenyl)-1-(4-ethoxyphenyl)-4-[hydroxy(phenyl)methylidene]pyrrolidine-2,3-dione chemical structure, C27H25NO6, CAS 797797-12-7
5-(3,4-Dimethoxyphenyl)-1-(4-ethoxyphenyl)-4-[hydroxy(phenyl)methylidene]pyrrolidine-2,3-dione
CAS 797797-12-7C27H25NO6
5-(4-Bromophenyl)-1-(4-ethoxyphenyl)-4-[hydroxy(phenyl)methylidene]pyrrolidine-2,3-dione chemical structure, C25H20BrNO4, CAS 488810-09-9
5-(4-Bromophenyl)-1-(4-ethoxyphenyl)-4-[hydroxy(phenyl)methylidene]pyrrolidine-2,3-dione
CAS 488810-09-9C25H20BrNO4
4-[Hydroxy(phenyl)methylidene]-1,5-bis(4-nitrophenyl)pyrrolidine-2,3-dione chemical structure, C23H15N3O7, CAS 5672-78-6
4-[Hydroxy(phenyl)methylidene]-1,5-bis(4-nitrophenyl)pyrrolidine-2,3-dione
CAS 5672-78-6C23H15N3O7
5-(2,5-Dimethoxyphenyl)-1-(4-ethoxyphenyl)-4-[hydroxy-(4-methylphenyl)methylidene]pyrrolidine-2,3-dione chemical structure, C28H27NO6, CAS 667909-13-9
5-(2,5-Dimethoxyphenyl)-1-(4-ethoxyphenyl)-4-[hydroxy-(4-methylphenyl)methylidene]pyrrolidine-2,3-dione
CAS 667909-13-9C28H27NO6
5-(3,4-Dimethoxyphenyl)-3-hydroxy-4-[(4-methylphenyl)carbonyl]-1-phenyl-1,5-dihydro-2H-pyrrol-2-one chemical structure, C26H23NO5, CAS 312502-22-0
5-(3,4-Dimethoxyphenyl)-3-hydroxy-4-[(4-methylphenyl)carbonyl]-1-phenyl-1,5-dihydro-2H-pyrrol-2-one
CAS 312502-22-0C26H23NO5
4-Benzoyl-5-(4-fluorophenyl)-3-hydroxy-1-{3-nitrophenyl}-1,5-dihydro-2H-pyrrol-2-one chemical structure, C23H15FN2O5, CAS 309283-06-5
4-Benzoyl-5-(4-fluorophenyl)-3-hydroxy-1-{3-nitrophenyl}-1,5-dihydro-2H-pyrrol-2-one
CAS 309283-06-5C23H15FN2O5
(4E)-4-[Hydroxy(phenyl)methylidene]-5-(2-nitrophenyl)-1-[3-(trifluoromethyl)phenyl]pyrrolidine-2,3-dione chemical structure, C24H15F3N2O5, CAS 309283-07-6
(4E)-4-[Hydroxy(phenyl)methylidene]-5-(2-nitrophenyl)-1-[3-(trifluoromethyl)phenyl]pyrrolidine-2,3-dione
CAS 309283-07-6C24H15F3N2O5
(4E)-5-(3-Fluorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-methylphenyl)pyrrolidine-2,3-dione chemical structure, C24H18FNO3, CAS 309721-28-6
(4E)-5-(3-Fluorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-methylphenyl)pyrrolidine-2,3-dione
CAS 309721-28-6C24H18FNO3
(4E)-5-(2-Fluorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-methylphenyl)pyrrolidine-2,3-dione chemical structure, C24H18FNO3, CAS 309721-29-7
(4E)-5-(2-Fluorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(3-methylphenyl)pyrrolidine-2,3-dione
CAS 309721-29-7C24H18FNO3
4-Benzoyl-5-(2,5-dimethoxyphenyl)-1-(4-fluorophenyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one chemical structure, C25H20FNO5, CAS 309725-69-7
4-Benzoyl-5-(2,5-dimethoxyphenyl)-1-(4-fluorophenyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one
CAS 309725-69-7C25H20FNO5
(4Z)-4-[Hydroxy(phenyl)methylidene]-1-(3-methoxyphenyl)-5-(4-nitrophenyl)pyrrolidine-2,3-dione chemical structure, C24H18N2O6, CAS 5954-36-9
(4Z)-4-[Hydroxy(phenyl)methylidene]-1-(3-methoxyphenyl)-5-(4-nitrophenyl)pyrrolidine-2,3-dione
CAS 5954-36-9C24H18N2O6
(4E)-5-(4-Hydroxy-3-methoxyphenyl)-4-[hydroxy(phenyl)methylidene]-1-[3-(trifluoromethyl)phenyl]pyrrolidine-2,3-dione chemical structure, C25H18F3NO5, CAS 342784-19-4
(4E)-5-(4-Hydroxy-3-methoxyphenyl)-4-[hydroxy(phenyl)methylidene]-1-[3-(trifluoromethyl)phenyl]pyrrolidine-2,3-dione
CAS 342784-19-4C25H18F3NO5
(4E)-4-[Hydroxy-(4-methylphenyl)methylidene]-5-(4-methoxyphenyl)-1-phenylpyrrolidine-2,3-dione chemical structure, C25H21NO4, CAS 5786-38-9
(4E)-4-[Hydroxy-(4-methylphenyl)methylidene]-5-(4-methoxyphenyl)-1-phenylpyrrolidine-2,3-dione
CAS 5786-38-9C25H21NO4
(4Z)-5-(3,4-Dimethoxyphenyl)-4-[hydroxy(phenyl)methylidene]-1-phenylpyrrolidine-2,3-dione chemical structure, C25H21NO5, CAS 5791-22-0
(4Z)-5-(3,4-Dimethoxyphenyl)-4-[hydroxy(phenyl)methylidene]-1-phenylpyrrolidine-2,3-dione
CAS 5791-22-0C25H21NO5
5-(2-Fluorophenyl)-3-hydroxy-4-(4-methylbenzoyl)-1-phenyl-1H-pyrrol-2(5H)-one chemical structure, C24H18FNO3, CAS 331751-62-3
5-(2-Fluorophenyl)-3-hydroxy-4-(4-methylbenzoyl)-1-phenyl-1H-pyrrol-2(5H)-one
CAS 331751-62-3C24H18FNO3
(4E)-5-(4-Fluorophenyl)-4-[hydroxy-(4-methylphenyl)methylidene]-1-phenylpyrrolidine-2,3-dione chemical structure, C24H18FNO3, CAS 331751-61-2
(4E)-5-(4-Fluorophenyl)-4-[hydroxy-(4-methylphenyl)methylidene]-1-phenylpyrrolidine-2,3-dione
CAS 331751-61-2C24H18FNO3
4-[(3Z)-3-[Hydroxy-(4-methylphenyl)methylidene]-2-(3-nitrophenyl)-4,5-dioxopyrrolidin-1-yl]benzenesulfonamide chemical structure, C24H19N3O7S, CAS 5792-56-3
4-[(3Z)-3-[Hydroxy-(4-methylphenyl)methylidene]-2-(3-nitrophenyl)-4,5-dioxopyrrolidin-1-yl]benzenesulfonamide
CAS 5792-56-3C24H19N3O7S
(4Z)-4-[Hydroxy(phenyl)methylidene]-1-(3-methoxyphenyl)-5-phenylpyrrolidine-2,3-dione chemical structure, C24H19NO4, CAS 5949-26-8
(4Z)-4-[Hydroxy(phenyl)methylidene]-1-(3-methoxyphenyl)-5-phenylpyrrolidine-2,3-dione
CAS 5949-26-8C24H19NO4