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Murcko scaffold

Ring system with 3 rings and 27 atoms

29 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
27
Chemicals
29
With full pages
9
Scaffold SMILES

O=C(COc1ccccc1)Nc1ccc(S(=O)(=O)Nc2ccncn2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(COc1ccccc1)Nc1ccc(S(=O)(=O)Nc2ccncn2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 29 of 29 chemicals

N-{4-[(2,6-Dimethylpyrimidin-4-yl)sulfamoyl]phenyl}-2-phenoxyacetamide chemical structure, C20H20N4O4S, CAS 331454-69-4
N-{4-[(2,6-Dimethylpyrimidin-4-yl)sulfamoyl]phenyl}-2-phenoxyacetamide
CAS 331454-69-4C20H20N4O4S
N-{4-[(2,6-Dimethoxypyrimidin-4-yl)sulfamoyl]phenyl}-2-(4-methylphenoxy)acetamide chemical structure, C21H22N4O6S, CAS 319428-59-6
N-{4-[(2,6-Dimethoxypyrimidin-4-yl)sulfamoyl]phenyl}-2-(4-methylphenoxy)acetamide
CAS 319428-59-6C21H22N4O6S
N-{4-[(2,6-Dimethoxypyrimidin-4-yl)sulfamoyl]phenyl}-2-(2,5-dimethylphenoxy)acetamide chemical structure, C22H24N4O6S, CAS 444065-29-6
N-{4-[(2,6-Dimethoxypyrimidin-4-yl)sulfamoyl]phenyl}-2-(2,5-dimethylphenoxy)acetamide
CAS 444065-29-6C22H24N4O6S
2-(2-Chlorophenoxy)-N-(4-{[(2,6-dimethoxy-4-pyrimidinyl)amino]sulfonyl}phenyl)acetamide chemical structure, C20H19ClN4O6S, CAS 581781-95-5
2-(2-Chlorophenoxy)-N-(4-{[(2,6-dimethoxy-4-pyrimidinyl)amino]sulfonyl}phenyl)acetamide
CAS 581781-95-5C20H19ClN4O6S
N-[4-[(2,6-Dimethylpyrimidin-4-yl)sulfamoyl]phenyl]-2-(5-methyl-2-propan-2-ylphenoxy)acetamide chemical structure, C24H28N4O4S, CAS 307545-14-8
N-[4-[(2,6-Dimethylpyrimidin-4-yl)sulfamoyl]phenyl]-2-(5-methyl-2-propan-2-ylphenoxy)acetamide
CAS 307545-14-8C24H28N4O4S
N-(4-{[(2,6-Dimethyl-4-pyrimidinyl)amino]sulfonyl}phenyl)-2-(4-isopropylphenoxy)acetamide chemical structure, C23H26N4O4S, CAS 307545-15-9
N-(4-{[(2,6-Dimethyl-4-pyrimidinyl)amino]sulfonyl}phenyl)-2-(4-isopropylphenoxy)acetamide
CAS 307545-15-9C23H26N4O4S
2-(4-Chloro-3,5-dimethylphenoxy)-N-(4-{[(2,6-dimethylpyrimidin-4-yl)amino]sulfonyl}phenyl)acetamide chemical structure, C22H23ClN4O4S, CAS 329226-00-8
2-(4-Chloro-3,5-dimethylphenoxy)-N-(4-{[(2,6-dimethylpyrimidin-4-yl)amino]sulfonyl}phenyl)acetamide
CAS 329226-00-8C22H23ClN4O4S
N-[4-(2,6-Dimethoxy-pyrimidin-4-ylsulfamoyl)-phenyl]-2-m-tolyloxy-acetamide chemical structure, C21H22N4O6S, CAS 327065-30-5
N-[4-(2,6-Dimethoxy-pyrimidin-4-ylsulfamoyl)-phenyl]-2-m-tolyloxy-acetamide
CAS 327065-30-5C21H22N4O6S
N-{4-[(2,6-Dimethylpyrimidin-4-yl)sulfamoyl]phenyl}-2-(4-methylphenoxy)acetamide chemical structure, C21H22N4O4S, CAS 451491-86-4
N-{4-[(2,6-Dimethylpyrimidin-4-yl)sulfamoyl]phenyl}-2-(4-methylphenoxy)acetamide
CAS 451491-86-4C21H22N4O4S
2-(2-Chlorophenoxy)-N-{4-[(2,6-dimethylpyrimidin-4-yl)sulfamoyl]phenyl}acetamide chemical structure, C20H19ClN4O4S, CAS 451491-96-6
2-(2-Chlorophenoxy)-N-{4-[(2,6-dimethylpyrimidin-4-yl)sulfamoyl]phenyl}acetamide
CAS 451491-96-6C20H19ClN4O4S
N-[4-[(2,6-Dimethoxypyrimidin-4-yl)sulfamoyl]phenyl]-2-(4-methoxyphenoxy)acetamide chemical structure, C21H22N4O7S, CAS 511517-78-5
N-[4-[(2,6-Dimethoxypyrimidin-4-yl)sulfamoyl]phenyl]-2-(4-methoxyphenoxy)acetamide
CAS 511517-78-5C21H22N4O7S
2-(2-Bromo-4-methylphenoxy)-N-{4-[(2,6-dimethylpyrimidin-4-yl)sulfamoyl]phenyl}acetamide chemical structure, C21H21BrN4O4S, CAS 340827-51-2
2-(2-Bromo-4-methylphenoxy)-N-{4-[(2,6-dimethylpyrimidin-4-yl)sulfamoyl]phenyl}acetamide
CAS 340827-51-2C21H21BrN4O4S
2-(3-Bromophenoxy)-N-{4-[(2,6-dimethylpyrimidin-4-yl)sulfamoyl]phenyl}acetamide chemical structure, C20H19BrN4O4S, CAS 307545-18-2
2-(3-Bromophenoxy)-N-{4-[(2,6-dimethylpyrimidin-4-yl)sulfamoyl]phenyl}acetamide
CAS 307545-18-2C20H19BrN4O4S
2-(4-Chloro-2-methylphenoxy)-N-{4-[(2,6-dimethylpyrimidin-4-yl)sulfamoyl]phenyl}acetamide chemical structure, C21H21ClN4O4S, CAS 329226-02-0
2-(4-Chloro-2-methylphenoxy)-N-{4-[(2,6-dimethylpyrimidin-4-yl)sulfamoyl]phenyl}acetamide
CAS 329226-02-0C21H21ClN4O4S
N-{4-[(2,6-Dimethylpyrimidin-4-yl)sulfamoyl]phenyl}-2-[3-methyl-4-(propan-2-yl)phenoxy]acetamide chemical structure, C24H28N4O4S, CAS 385416-79-5
N-{4-[(2,6-Dimethylpyrimidin-4-yl)sulfamoyl]phenyl}-2-[3-methyl-4-(propan-2-yl)phenoxy]acetamide
CAS 385416-79-5C24H28N4O4S
N-[4-[(2,6-Dimethylpyrimidin-4-yl)sulfamoyl]phenyl]-2-(2,4,6-trimethylphenoxy)acetamide chemical structure, C23H26N4O4S, CAS 381186-93-2
N-[4-[(2,6-Dimethylpyrimidin-4-yl)sulfamoyl]phenyl]-2-(2,4,6-trimethylphenoxy)acetamide
CAS 381186-93-2C23H26N4O4S
N-[4-[(2,6-Dimethylpyrimidin-4-yl)sulfamoyl]phenyl]-2-(2-nitrophenoxy)acetamide chemical structure, C20H19N5O6S, CAS 307545-19-3
N-[4-[(2,6-Dimethylpyrimidin-4-yl)sulfamoyl]phenyl]-2-(2-nitrophenoxy)acetamide
CAS 307545-19-3C20H19N5O6S
N-{4-[(2,6-Dimethoxypyrimidin-4-yl)sulfamoyl]phenyl}-2-(4-nitrophenoxy)acetamide chemical structure, C20H19N5O8S, CAS 433689-15-7
N-{4-[(2,6-Dimethoxypyrimidin-4-yl)sulfamoyl]phenyl}-2-(4-nitrophenoxy)acetamide
CAS 433689-15-7C20H19N5O8S
2-(4-Bromophenoxy)-N-{4-[(2,6-dimethylpyrimidin-4-yl)sulfamoyl]phenyl}acetamide chemical structure, C20H19BrN4O4S, CAS 451491-87-5
2-(4-Bromophenoxy)-N-{4-[(2,6-dimethylpyrimidin-4-yl)sulfamoyl]phenyl}acetamide
CAS 451491-87-5C20H19BrN4O4S
N-(4-{[(2,6-Dimethoxy-4-pyrimidinyl)amino]sulfonyl}phenyl)-2-(2,4-dimethylphenoxy)acetamide chemical structure, C22H24N4O6S, CAS 651295-38-4
N-(4-{[(2,6-Dimethoxy-4-pyrimidinyl)amino]sulfonyl}phenyl)-2-(2,4-dimethylphenoxy)acetamide
CAS 651295-38-4C22H24N4O6S
2-(4-Chlorophenoxy)-N-{4-[(2,6-dimethylpyrimidin-4-yl)sulfamoyl]phenyl}acetamide chemical structure, C20H19ClN4O4S, CAS 373619-95-5
2-(4-Chlorophenoxy)-N-{4-[(2,6-dimethylpyrimidin-4-yl)sulfamoyl]phenyl}acetamide
CAS 373619-95-5C20H19ClN4O4S
N-[4-(2,6-Dimethyl-pyrimidin-4-ylsulfamoyl)-phenyl]-2-m-tolyloxy-acetamide chemical structure, C21H22N4O4S, CAS 307545-13-7
N-[4-(2,6-Dimethyl-pyrimidin-4-ylsulfamoyl)-phenyl]-2-m-tolyloxy-acetamide
CAS 307545-13-7C21H22N4O4S
2-(3-Chlorophenoxy)-N-[4-[(2,6-dimethylpyrimidin-4-yl)sulfamoyl]phenyl]propanamide chemical structure, C21H21ClN4O4S, CAS 425372-59-4
2-(3-Chlorophenoxy)-N-[4-[(2,6-dimethylpyrimidin-4-yl)sulfamoyl]phenyl]propanamide
CAS 425372-59-4C21H21ClN4O4S
N-{4-[(2,6-Dimethylpyrimidin-4-yl)sulfamoyl]phenyl}-2-(4-fluorophenoxy)propanamide chemical structure, C21H21FN4O4S, CAS 617696-75-0
N-{4-[(2,6-Dimethylpyrimidin-4-yl)sulfamoyl]phenyl}-2-(4-fluorophenoxy)propanamide
CAS 617696-75-0C21H21FN4O4S