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Murcko scaffold

Ring system with 3 rings and 25 atoms

70 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
70
With full pages
45
Scaffold SMILES

O=C(NN=Cc1ccccc1)c1ccc(OCc2ccccc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NN=Cc1ccccc1)c1ccc(OCc2ccccc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 70 chemicals

4-[(4-Methylphenyl)methoxy]benzoic acid 2-[(4-chloro-3-nitrophenyl)methylene]hydrazide chemical structure, C22H18ClN3O4, CAS 320423-64-1
4-[(4-Methylphenyl)methoxy]benzoic acid 2-[(4-chloro-3-nitrophenyl)methylene]hydrazide
CAS 320423-64-1C22H18ClN3O4
4-[(3,4-Dichlorophenyl)methoxy]-N-[(Z)-(3,4-dimethoxyphenyl)methylideneamino]benzamide chemical structure, C23H20Cl2N2O4, CAS 303987-17-9
4-[(3,4-Dichlorophenyl)methoxy]-N-[(Z)-(3,4-dimethoxyphenyl)methylideneamino]benzamide
CAS 303987-17-9C23H20Cl2N2O4
4-(Benzyloxy)-N'-[(1E)-1-(4-tert-butylphenyl)ethylidene]benzohydrazide chemical structure, C26H28N2O2, CAS 327999-56-4
4-(Benzyloxy)-N'-[(1E)-1-(4-tert-butylphenyl)ethylidene]benzohydrazide
CAS 327999-56-4C26H28N2O2
N-[(Z)-(4-tert-Butylphenyl)methylideneamino]-4-[(3,4-dichlorophenyl)methoxy]benzamide chemical structure, C25H24Cl2N2O2, CAS 320423-46-9
N-[(Z)-(4-tert-Butylphenyl)methylideneamino]-4-[(3,4-dichlorophenyl)methoxy]benzamide
CAS 320423-46-9C25H24Cl2N2O2
4-[(3-Bromobenzyl)oxy]-N'-(4-iodobenzylidene)benzohydrazide chemical structure, C21H16BrIN2O2, CAS 342788-66-3
4-[(3-Bromobenzyl)oxy]-N'-(4-iodobenzylidene)benzohydrazide
CAS 342788-66-3C21H16BrIN2O2
Methyl 4-(2-(4-((4-methylbenzyl)oxy)benzoyl)carbohydrazonoyl)benzoate chemical structure, C24H22N2O4, CAS 302569-94-4
Methyl 4-(2-(4-((4-methylbenzyl)oxy)benzoyl)carbohydrazonoyl)benzoate
CAS 302569-94-4C24H22N2O4
N-{4-[((E)-2-{4-[(4-methylbenzyl)oxy]benzoyl}hydrazono)methyl]phenyl}acetamide chemical structure, C24H23N3O3, CAS 320423-66-3
N-{4-[((E)-2-{4-[(4-methylbenzyl)oxy]benzoyl}hydrazono)methyl]phenyl}acetamide
CAS 320423-66-3C24H23N3O3
4-[(3,4-Dichlorobenzyl)oxy]-N'-[(E)-(4-fluorophenyl)methylidene]benzenecarbohydrazide chemical structure, C21H15Cl2FN2O2, CAS 303987-18-0
4-[(3,4-Dichlorobenzyl)oxy]-N'-[(E)-(4-fluorophenyl)methylidene]benzenecarbohydrazide
CAS 303987-18-0C21H15Cl2FN2O2
4-[(2-Chloro-6-fluorobenzyl)oxy]-N'-[(E)-(4-methylphenyl)methylidene]benzenecarbohydrazide chemical structure, C22H18ClFN2O2, CAS 303987-26-0
4-[(2-Chloro-6-fluorobenzyl)oxy]-N'-[(E)-(4-methylphenyl)methylidene]benzenecarbohydrazide
CAS 303987-26-0C22H18ClFN2O2
N'-[(E)-(3-Bromophenyl)methylidene]-4-[(3,4-dichlorobenzyl)oxy]benzenecarbohydrazide chemical structure, C21H15BrCl2N2O2, CAS 303987-28-2
N'-[(E)-(3-Bromophenyl)methylidene]-4-[(3,4-dichlorobenzyl)oxy]benzenecarbohydrazide
CAS 303987-28-2C21H15BrCl2N2O2
4-[(3,4-Dichlorobenzyl)oxy]-N'-[(E)-(3-nitrophenyl)methylidene]benzenecarbohydrazide chemical structure, C21H15Cl2N3O4, CAS 303987-29-3
4-[(3,4-Dichlorobenzyl)oxy]-N'-[(E)-(3-nitrophenyl)methylidene]benzenecarbohydrazide
CAS 303987-29-3C21H15Cl2N3O4
4-[(3,4-Dichlorobenzyl)oxy]-N'-[(E)-(2,3,4,5,6-pentafluorophenyl)methylidene]benzenecarbohydrazide chemical structure, C21H11Cl2F5N2O2, CAS 303987-45-3
4-[(3,4-Dichlorobenzyl)oxy]-N'-[(E)-(2,3,4,5,6-pentafluorophenyl)methylidene]benzenecarbohydrazide
CAS 303987-45-3C21H11Cl2F5N2O2
4-((4-Chlorobenzyl)oxy)-N'-(2,5-dimethoxybenzylidene)benzohydrazide chemical structure, C23H21ClN2O4, CAS 330972-13-9
4-((4-Chlorobenzyl)oxy)-N'-(2,5-dimethoxybenzylidene)benzohydrazide
CAS 330972-13-9C23H21ClN2O4
4-((4-Chlorobenzyl)oxy)-N'-(4-(diethylamino)benzylidene)benzohydrazide chemical structure, C25H26ClN3O2, CAS 332146-90-4
4-((4-Chlorobenzyl)oxy)-N'-(4-(diethylamino)benzylidene)benzohydrazide
CAS 332146-90-4C25H26ClN3O2
4-[(4-Chlorobenzyl)oxy]-N'-{(E)-[4-(dimethylamino)phenyl]methylidene}benzohydrazide chemical structure, C23H22ClN3O2, CAS 339247-72-2
4-[(4-Chlorobenzyl)oxy]-N'-{(E)-[4-(dimethylamino)phenyl]methylidene}benzohydrazide
CAS 339247-72-2C23H22ClN3O2
4-[(4-Chlorobenzyl)oxy]-N'-[(E)-(4-ethoxyphenyl)methylidene]benzohydrazide chemical structure, C23H21ClN2O3, CAS 393139-02-1
4-[(4-Chlorobenzyl)oxy]-N'-[(E)-(4-ethoxyphenyl)methylidene]benzohydrazide
CAS 393139-02-1C23H21ClN2O3
N'-(4-(Dimethylamino)benzylidene)-4-((4-methylbenzyl)oxy)benzohydrazide chemical structure, C24H25N3O2, CAS 769156-10-7
N'-(4-(Dimethylamino)benzylidene)-4-((4-methylbenzyl)oxy)benzohydrazide
CAS 769156-10-7C24H25N3O2
N'-[(E)-(2,6-Dichlorophenyl)methylidene]-4-[(4-methylbenzyl)oxy]benzohydrazide chemical structure, C22H18Cl2N2O2, CAS 340224-47-7
N'-[(E)-(2,6-Dichlorophenyl)methylidene]-4-[(4-methylbenzyl)oxy]benzohydrazide
CAS 340224-47-7C22H18Cl2N2O2
4-((4-Chlorobenzyl)oxy)-N'-(3,4,5-trimethoxybenzylidene)benzohydrazide chemical structure, C24H23ClN2O5, CAS 395088-94-5
4-((4-Chlorobenzyl)oxy)-N'-(3,4,5-trimethoxybenzylidene)benzohydrazide
CAS 395088-94-5C24H23ClN2O5
N'-(2-(Allyloxy)-5-bromobenzylidene)-4-((4-methylbenzyl)oxy)benzohydrazide chemical structure, C25H23BrN2O3, CAS 765307-21-9
N'-(2-(Allyloxy)-5-bromobenzylidene)-4-((4-methylbenzyl)oxy)benzohydrazide
CAS 765307-21-9C25H23BrN2O3
N'-[(E)-(5-Bromo-2-ethoxyphenyl)methylidene]-4-[(3,4-dichlorobenzyl)oxy]benzenecarbohydrazide chemical structure, C23H19BrCl2N2O3, CAS 477868-63-6
N'-[(E)-(5-Bromo-2-ethoxyphenyl)methylidene]-4-[(3,4-dichlorobenzyl)oxy]benzenecarbohydrazide
CAS 477868-63-6C23H19BrCl2N2O3
N'-(5-Bromo-2-methoxybenzylidene)-4-((4-methylbenzyl)oxy)benzohydrazide chemical structure, C23H21BrN2O3, CAS 765278-32-8
N'-(5-Bromo-2-methoxybenzylidene)-4-((4-methylbenzyl)oxy)benzohydrazide
CAS 765278-32-8C23H21BrN2O3
4-[(3,4-Dichlorobenzyl)oxy]-N'-[(E)-phenylmethylidene]benzenecarbohydrazide chemical structure, C21H16Cl2N2O2, CAS 320423-55-0
4-[(3,4-Dichlorobenzyl)oxy]-N'-[(E)-phenylmethylidene]benzenecarbohydrazide
CAS 320423-55-0C21H16Cl2N2O2
4-((4-Chlorobenzyl)oxy)-N'-(2,6-dichlorobenzylidene)benzohydrazide chemical structure, C21H15Cl3N2O2, CAS 396110-14-8
4-((4-Chlorobenzyl)oxy)-N'-(2,6-dichlorobenzylidene)benzohydrazide
CAS 396110-14-8C21H15Cl3N2O2