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Murcko scaffold

Ring system with 3 rings and 25 atoms

225 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
225
With full pages
8
Scaffold SMILES

O=C(C=Cc1ccc(OCc2ccccc2)cc1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccc(OCc2ccccc2)cc1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 225 chemicals

(E)-3-[4-[(4-Chlorophenyl)methoxy]-3-methoxyphenyl]-N-(3-nitrophenyl)prop-2-enamide chemical structure, C23H19ClN2O5, CAS 347363-40-0
(E)-3-[4-[(4-Chlorophenyl)methoxy]-3-methoxyphenyl]-N-(3-nitrophenyl)prop-2-enamide
CAS 347363-40-0C23H19ClN2O5
(E)-Methyl 4-(3-(4-((4-chlorobenzyl)oxy)-3-methoxyphenyl)acrylamido)benzoate chemical structure, C25H22ClNO5, CAS 347363-64-8
(E)-Methyl 4-(3-(4-((4-chlorobenzyl)oxy)-3-methoxyphenyl)acrylamido)benzoate
CAS 347363-64-8C25H22ClNO5
Methyl 3-{[(2E)-3-{4-[(4-chlorobenzyl)oxy]-3-methoxyphenyl}prop-2-enoyl]amino}benzoate chemical structure, C25H22ClNO5, CAS 347363-66-0
Methyl 3-{[(2E)-3-{4-[(4-chlorobenzyl)oxy]-3-methoxyphenyl}prop-2-enoyl]amino}benzoate
CAS 347363-66-0C25H22ClNO5
(2E)-3-[3-Methoxy-4-(phenylmethoxy)phenyl]-N-(4-sulfamoylphenyl)prop-2-enamide chemical structure, C23H22N2O5S, CAS 433255-52-8
(2E)-3-[3-Methoxy-4-(phenylmethoxy)phenyl]-N-(4-sulfamoylphenyl)prop-2-enamide
CAS 433255-52-8C23H22N2O5S
4-[(4-{(1Z)-3-[(4-Chlorophenyl)amino]-2-cyano-3-oxoprop-1-en-1-yl}-2-methoxyphenoxy)methyl]benzoic acid chemical structure, C25H19ClN2O5, CAS 340225-53-8
4-[(4-{(1Z)-3-[(4-Chlorophenyl)amino]-2-cyano-3-oxoprop-1-en-1-yl}-2-methoxyphenoxy)methyl]benzoic acid
CAS 340225-53-8C25H19ClN2O5
4-[(4-{(1Z)-3-[(4-Chlorophenyl)amino]-2-cyano-3-oxoprop-1-en-1-yl}-2-ethoxyphenoxy)methyl]benzoic acid chemical structure, C26H21ClN2O5, CAS 340308-92-1
4-[(4-{(1Z)-3-[(4-Chlorophenyl)amino]-2-cyano-3-oxoprop-1-en-1-yl}-2-ethoxyphenoxy)methyl]benzoic acid
CAS 340308-92-1C26H21ClN2O5
4-[[4-[(E)-3-(4-Chloroanilino)-2-cyano-3-oxoprop-1-enyl]phenoxy]methyl]benzoic acid chemical structure, C24H17ClN2O4, CAS 340220-60-2
4-[[4-[(E)-3-(4-Chloroanilino)-2-cyano-3-oxoprop-1-enyl]phenoxy]methyl]benzoic acid
CAS 340220-60-2C24H17ClN2O4
4-[[4-[(Z)-3-Anilino-2-cyano-3-oxoprop-1-enyl]-2-methoxyphenoxy]methyl]benzoic acid chemical structure, C25H20N2O5, CAS 340229-82-5
4-[[4-[(Z)-3-Anilino-2-cyano-3-oxoprop-1-enyl]-2-methoxyphenoxy]methyl]benzoic acid
CAS 340229-82-5C25H20N2O5
4-[[4-[(Z)-2-Cyano-3-(4-methoxyanilino)-3-oxoprop-1-enyl]-2-ethoxyphenoxy]methyl]benzoic acid chemical structure, C27H24N2O6, CAS 340228-01-5
4-[[4-[(Z)-2-Cyano-3-(4-methoxyanilino)-3-oxoprop-1-enyl]-2-ethoxyphenoxy]methyl]benzoic acid
CAS 340228-01-5C27H24N2O6
(E)-N-(4-Methoxyphenyl)-3-(4-phenylmethoxyphenyl)prop-2-enamide chemical structure, C23H21NO3, CAS 466661-54-1
(E)-N-(4-Methoxyphenyl)-3-(4-phenylmethoxyphenyl)prop-2-enamide
CAS 466661-54-1C23H21NO3
(E)-3-{4-[(4-Bromobenzyl)oxy]phenyl}-N-(3-methoxyphenyl)-2-propenamide chemical structure, C23H20BrNO3, CAS 477889-44-4
(E)-3-{4-[(4-Bromobenzyl)oxy]phenyl}-N-(3-methoxyphenyl)-2-propenamide
CAS 477889-44-4C23H20BrNO3
(E)-3-{4-[(4-Bromobenzyl)oxy]phenyl}-N-(4-methoxyphenyl)-2-propenamide chemical structure, C23H20BrNO3, CAS 477889-46-6
(E)-3-{4-[(4-Bromobenzyl)oxy]phenyl}-N-(4-methoxyphenyl)-2-propenamide
CAS 477889-46-6C23H20BrNO3
(E)-3-[4-[(2-Chloro-6-fluorophenyl)methoxy]phenyl]-N-(4-methoxyphenyl)prop-2-enamide chemical structure, C23H19ClFNO3, CAS 477870-77-2
(E)-3-[4-[(2-Chloro-6-fluorophenyl)methoxy]phenyl]-N-(4-methoxyphenyl)prop-2-enamide
CAS 477870-77-2C23H19ClFNO3
(E)-3-{4-[(3-Chlorobenzyl)oxy]phenyl}-N-(4-methoxyphenyl)-2-propenamide chemical structure, C23H20ClNO3, CAS 477871-21-9
(E)-3-{4-[(3-Chlorobenzyl)oxy]phenyl}-N-(4-methoxyphenyl)-2-propenamide
CAS 477871-21-9C23H20ClNO3
3-[[(E)-2-Cyano-3-[3-methoxy-4-[(4-methylphenyl)methoxy]phenyl]prop-2-enoyl]amino]benzoic acid chemical structure, C26H22N2O5, CAS 380475-42-3
3-[[(E)-2-Cyano-3-[3-methoxy-4-[(4-methylphenyl)methoxy]phenyl]prop-2-enoyl]amino]benzoic acid
CAS 380475-42-3C26H22N2O5
3-[[(E)-3-[4-[(4-Chlorophenyl)methoxy]-3-methoxyphenyl]-2-cyanoprop-2-enoyl]amino]benzoic acid chemical structure, C25H19ClN2O5, CAS 380475-62-7
3-[[(E)-3-[4-[(4-Chlorophenyl)methoxy]-3-methoxyphenyl]-2-cyanoprop-2-enoyl]amino]benzoic acid
CAS 380475-62-7C25H19ClN2O5
3-[[(E)-3-[4-[(2-Chlorophenyl)methoxy]-3-methoxyphenyl]-2-cyanoprop-2-enoyl]amino]benzoic acid chemical structure, C25H19ClN2O5, CAS 380475-61-6
3-[[(E)-3-[4-[(2-Chlorophenyl)methoxy]-3-methoxyphenyl]-2-cyanoprop-2-enoyl]amino]benzoic acid
CAS 380475-61-6C25H19ClN2O5
3-[[(E)-3-[4-[(2-Chlorophenyl)methoxy]-3-ethoxyphenyl]-2-cyanoprop-2-enoyl]amino]benzoic acid chemical structure, C26H21ClN2O5, CAS 380474-93-1
3-[[(E)-3-[4-[(2-Chlorophenyl)methoxy]-3-ethoxyphenyl]-2-cyanoprop-2-enoyl]amino]benzoic acid
CAS 380474-93-1C26H21ClN2O5
3-[[(E)-2-Cyano-3-[4-[(4-fluorophenyl)methoxy]-3-methoxyphenyl]prop-2-enoyl]amino]benzoic acid chemical structure, C25H19FN2O5, CAS 380475-54-7
3-[[(E)-2-Cyano-3-[4-[(4-fluorophenyl)methoxy]-3-methoxyphenyl]prop-2-enoyl]amino]benzoic acid
CAS 380475-54-7C25H19FN2O5
(E)-2-Cyano-N-(2,5-dimethylphenyl)-3-[4-[(4-methylphenyl)methoxy]phenyl]prop-2-enamide chemical structure, C26H24N2O2, CAS 380476-55-1
(E)-2-Cyano-N-(2,5-dimethylphenyl)-3-[4-[(4-methylphenyl)methoxy]phenyl]prop-2-enamide
CAS 380476-55-1C26H24N2O2
(E)-N-(4-Acetamidophenyl)-3-[4-[(4-chlorophenyl)methoxy]-3-methoxyphenyl]-2-cyanoprop-2-enamide chemical structure, C26H22ClN3O4, CAS 380477-74-7
(E)-N-(4-Acetamidophenyl)-3-[4-[(4-chlorophenyl)methoxy]-3-methoxyphenyl]-2-cyanoprop-2-enamide
CAS 380477-74-7C26H22ClN3O4
(E)-N-(4-Acetamidophenyl)-3-[4-[(2-chlorophenyl)methoxy]-3-methoxyphenyl]-2-cyanoprop-2-enamide chemical structure, C26H22ClN3O4, CAS 380477-19-0
(E)-N-(4-Acetamidophenyl)-3-[4-[(2-chlorophenyl)methoxy]-3-methoxyphenyl]-2-cyanoprop-2-enamide
CAS 380477-19-0C26H22ClN3O4
(E)-N-(4-Acetamidophenyl)-2-cyano-3-[3-ethoxy-4-[(4-fluorophenyl)methoxy]phenyl]prop-2-enamide chemical structure, C27H24FN3O4, CAS 380477-13-4
(E)-N-(4-Acetamidophenyl)-2-cyano-3-[3-ethoxy-4-[(4-fluorophenyl)methoxy]phenyl]prop-2-enamide
CAS 380477-13-4C27H24FN3O4
(2E)-N-[4-(Acetylamino)phenyl]-3-{4-[(4-bromobenzyl)oxy]-3-ethoxyphenyl}-2-cyanoprop-2-enamide chemical structure, C27H24BrN3O4, CAS 380475-30-9
(2E)-N-[4-(Acetylamino)phenyl]-3-{4-[(4-bromobenzyl)oxy]-3-ethoxyphenyl}-2-cyanoprop-2-enamide
CAS 380475-30-9C27H24BrN3O4