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Murcko scaffold

4-Piperazin-1-yl-quinoline scaffold

392 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
392
With full pages
14
Scaffold SMILES

c1ccc2c(N3CCNCC3)ccnc2c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-Piperazin-1-yl-quinoline page
Murcko scaffold c1ccc2c(N3CCNCC3)ccnc2c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 392 chemicals

1-[6,8-Dichloro-2-(trifluoromethyl)quinol-4yl]piperazine chemical structure, C14H12Cl2F3N3, CAS 1000339-48-9
1-[6,8-Dichloro-2-(trifluoromethyl)quinol-4yl]piperazine
CAS 1000339-48-9C14H12Cl2F3N3
Butyl 6-bromo-4-(4-(tert-butoxycarbonyl)piperazin-1-yl)quinoline-2-carboxylate chemical structure, C23H30BrN3O4, CAS 887589-51-7
Butyl 6-bromo-4-(4-(tert-butoxycarbonyl)piperazin-1-yl)quinoline-2-carboxylate
CAS 887589-51-7C23H30BrN3O4
Butyl 4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-5,8-dimethylquinoline-2-carboxylate chemical structure, C25H35N3O4, CAS 887589-55-1
Butyl 4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-5,8-dimethylquinoline-2-carboxylate
CAS 887589-55-1C25H35N3O4
Methyl 4-[4-(tert-butoxycarbonyl)piperazin-1-yl]-6-chloroquinoline-2-carboxylate chemical structure, C20H24ClN3O4, CAS 914220-46-5
Methyl 4-[4-(tert-butoxycarbonyl)piperazin-1-yl]-6-chloroquinoline-2-carboxylate
CAS 914220-46-5C20H24ClN3O4
6-Chloro-2-methyl-4-(piperazin-1-yl)quinoline chemical structure, C14H16ClN3, CAS 1146293-27-7
6-Chloro-2-methyl-4-(piperazin-1-yl)quinoline
CAS 1146293-27-7C14H16ClN3
Quinoline, 8-chloro-2-methyl-4-(1-piperazinyl)- chemical structure, C14H16ClN3, CAS 1146293-28-8
Quinoline, 8-chloro-2-methyl-4-(1-piperazinyl)-
CAS 1146293-28-8C14H16ClN3
4-(Piperazin-1-yl)quinoline-3-carbonitrile chemical structure, C14H14N4, CAS 1153167-35-1
4-(Piperazin-1-yl)quinoline-3-carbonitrile
CAS 1153167-35-1C14H14N4
4-(4-Acetyl-1-piperazinyl)-3-quinolinecarbonitrile chemical structure, C16H16N4O, CAS 1156318-37-4
4-(4-Acetyl-1-piperazinyl)-3-quinolinecarbonitrile
CAS 1156318-37-4C16H16N4O
2,8-Bis(trifluoromethyl)-4-(piperazin-1-yl)quinoline hydrochloride chemical structure, C15H14ClF6N3, CAS 1170789-64-6
2,8-Bis(trifluoromethyl)-4-(piperazin-1-yl)quinoline hydrochloride
CAS 1170789-64-6C15H14ClF6N3
1-[4-(2-Methylquinolin-4-yl)piperazin-1-yl]ethan-1-one chemical structure, C16H19N3O, CAS 858851-50-0
1-[4-(2-Methylquinolin-4-yl)piperazin-1-yl]ethan-1-one
CAS 858851-50-0C16H19N3O
7-Bromo-4-(piperazin-1-yl)quinoline-3-carbonitrile chemical structure, C14H13BrN4, CAS 1255781-94-2
7-Bromo-4-(piperazin-1-yl)quinoline-3-carbonitrile
CAS 1255781-94-2C14H13BrN4
4-(Piperazin-1-yl)-6-(trifluoromethyl)quinoline-3-carbonitrile chemical structure, C15H13F3N4, CAS 1255780-45-0
4-(Piperazin-1-yl)-6-(trifluoromethyl)quinoline-3-carbonitrile
CAS 1255780-45-0C15H13F3N4
6-Fluoro-4-(piperazin-1-yl)quinoline-3-carbonitrile chemical structure, C14H13FN4, CAS 1255779-50-0
6-Fluoro-4-(piperazin-1-yl)quinoline-3-carbonitrile
CAS 1255779-50-0C14H13FN4
6-Chloro-4-(piperazin-1-yl)quinoline-3-carbonitrile chemical structure, C14H13ClN4, CAS 1255780-90-5
6-Chloro-4-(piperazin-1-yl)quinoline-3-carbonitrile
CAS 1255780-90-5C14H13ClN4
6-Methyl-4-(piperazin-1-yl)quinoline-3-carbonitrile chemical structure, C15H16N4, CAS 1255781-92-0
6-Methyl-4-(piperazin-1-yl)quinoline-3-carbonitrile
CAS 1255781-92-0C15H16N4
6-Methoxy-4-(piperazin-1-yl)quinoline-3-carbonitrile chemical structure, C15H16N4O, CAS 1255780-54-1
6-Methoxy-4-(piperazin-1-yl)quinoline-3-carbonitrile
CAS 1255780-54-1C15H16N4O
Ethyl 8-cyano-4-(piperazin-1-yl)quinoline-3-carboxylate chemical structure, C17H18N4O2, CAS 1279214-94-6
Ethyl 8-cyano-4-(piperazin-1-yl)quinoline-3-carboxylate
CAS 1279214-94-6C17H18N4O2
Ethyl 6-ethyl-4-(piperazin-1-yl)quinoline-3-carboxylate chemical structure, C18H23N3O2, CAS 1279210-14-8
Ethyl 6-ethyl-4-(piperazin-1-yl)quinoline-3-carboxylate
CAS 1279210-14-8C18H23N3O2
2-Methyl-4-(1-piperazinyl)quinoline dihydrochloride chemical structure, C14H19Cl2N3, CAS 1215504-19-0
2-Methyl-4-(1-piperazinyl)quinoline dihydrochloride
CAS 1215504-19-0C14H19Cl2N3
tert-Butyl 4-(6-aminoquinolin-4-yl)piperazine-1-carboxylate chemical structure, C18H24N4O2, CAS 227957-05-3
tert-Butyl 4-(6-aminoquinolin-4-yl)piperazine-1-carboxylate
CAS 227957-05-3C18H24N4O2
Ethyl 6-fluoro-8-methyl-4-(piperazin-1-yl)quinoline-3-carboxylate chemical structure, C17H20FN3O2, CAS 1315345-09-5
Ethyl 6-fluoro-8-methyl-4-(piperazin-1-yl)quinoline-3-carboxylate
CAS 1315345-09-5C17H20FN3O2
Ethyl 5,8-difluoro-4-(piperazin-1-yl)quinoline-3-carboxylate chemical structure, C16H17F2N3O2, CAS 1315370-79-6
Ethyl 5,8-difluoro-4-(piperazin-1-yl)quinoline-3-carboxylate
CAS 1315370-79-6C16H17F2N3O2
Ethyl 7-chloro-6-methoxy-4-(piperazin-1-yl)quinoline-3-carboxylate chemical structure, C17H20ClN3O3, CAS 1315376-32-9
Ethyl 7-chloro-6-methoxy-4-(piperazin-1-yl)quinoline-3-carboxylate
CAS 1315376-32-9C17H20ClN3O3
Ethyl 8-methoxy-6-methyl-4-(piperazin-1-yl)quinoline-3-carboxylate chemical structure, C18H23N3O3, CAS 1315376-35-2
Ethyl 8-methoxy-6-methyl-4-(piperazin-1-yl)quinoline-3-carboxylate
CAS 1315376-35-2C18H23N3O3