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Murcko scaffold

Ring system with 4 rings and 21 atoms

22 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
21
Chemicals
22
With full pages
4
Scaffold SMILES

c1ccc(-c2ccn3nc(-c4ccccc4)cc3n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2ccn3nc(-c4ccccc4)cc3n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

2,5-Bis(4-methylphenyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C20H18N4, CAS 310422-22-1
2,5-Bis(4-methylphenyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 310422-22-1C20H18N4
7-Methyl-2-(4-methylphenyl)-5-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C20H17N3, CAS 309266-75-9
7-Methyl-2-(4-methylphenyl)-5-phenylpyrazolo[1,5-a]pyrimidine
CAS 309266-75-9C20H17N3
2,5-Diphenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C19H12F3N3, CAS 299921-84-9
2,5-Diphenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 299921-84-9C19H12F3N3
2,5-Diphenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C18H14N4, CAS 310422-25-4
2,5-Diphenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 310422-25-4C18H14N4
2-(4-Methylphenyl)-5-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C19H16N4, CAS 331844-83-8
2-(4-Methylphenyl)-5-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 331844-83-8C19H16N4
5-(4-Bromophenyl)-2-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C18H13BrN4, CAS 331844-86-1
5-(4-Bromophenyl)-2-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 331844-86-1C18H13BrN4
5-(4-Methoxyphenyl)-2-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C21H16F3N3O, CAS 401588-47-4
5-(4-Methoxyphenyl)-2-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 401588-47-4C21H16F3N3O
5-(4-Methoxyphenyl)-2-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C20H14F3N3O, CAS 299919-80-5
5-(4-Methoxyphenyl)-2-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 299919-80-5C20H14F3N3O
5-(3-Methoxyphenyl)-2-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C20H14F3N3O, CAS 700852-49-9
5-(3-Methoxyphenyl)-2-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 700852-49-9C20H14F3N3O
2-(4-Methoxyphenyl)-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C21H16F3N3O, CAS 690969-37-0
2-(4-Methoxyphenyl)-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 690969-37-0C21H16F3N3O
5-(4-Fluorophenyl)-2-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C19H11F4N3, CAS 654053-58-4
5-(4-Fluorophenyl)-2-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 654053-58-4C19H11F4N3
5-(4-Methylphenyl)-2-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C20H14F3N3, CAS 346644-37-9
5-(4-Methylphenyl)-2-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 346644-37-9C20H14F3N3
2-(4-Methylphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C20H14F3N3, CAS 402572-89-8
2-(4-Methylphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 402572-89-8C20H14F3N3
5-(3-Chlorophenyl)-2-(3,4-dichlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C19H9Cl3F3N3, CAS 477848-55-8
5-(3-Chlorophenyl)-2-(3,4-dichlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 477848-55-8C19H9Cl3F3N3
2-(3,4-Dichlorophenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C19H10Cl2F3N3, CAS 477848-56-9
2-(3,4-Dichlorophenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 477848-56-9C19H10Cl2F3N3
3-Chloro-2-(3,4-dichlorophenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C19H9Cl3F3N3, CAS 477858-78-9
3-Chloro-2-(3,4-dichlorophenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 477858-78-9C19H9Cl3F3N3
3-Chloro-5-(3-chlorophenyl)-2-(3,4-dichlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C19H8Cl4F3N3, CAS 691868-55-0
3-Chloro-5-(3-chlorophenyl)-2-(3,4-dichlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 691868-55-0C19H8Cl4F3N3
7-[Chloro(difluoro)methyl]-2-(3,4-dichlorophenyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine chemical structure, C20H9Cl3F5N3, CAS 439096-11-4
7-[Chloro(difluoro)methyl]-2-(3,4-dichlorophenyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine
CAS 439096-11-4C20H9Cl3F5N3
7-Chloro-2-(3-chlorophenyl)-5-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C18H11Cl2N3, CAS 77493-91-5
7-Chloro-2-(3-chlorophenyl)-5-phenylpyrazolo[1,5-a]pyrimidine
CAS 77493-91-5C18H11Cl2N3
2,5-Bis(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C18H12Cl2N4, CAS 941233-75-6
2,5-Bis(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 941233-75-6C18H12Cl2N4
7-Chloro-2-(4-chloro-phenyl)-5-phenyl-pyrazolo[1,5-a]pyrimidine chemical structure, C18H11Cl2N3, CAS 889939-44-0
7-Chloro-2-(4-chloro-phenyl)-5-phenyl-pyrazolo[1,5-a]pyrimidine
CAS 889939-44-0C18H11Cl2N3
7-Chloro-2-(3-methoxy-phenyl)-5-phenyl-pyrazolo[1,5-a]pyrimidine chemical structure, C19H14ClN3O, CAS 889939-49-5
7-Chloro-2-(3-methoxy-phenyl)-5-phenyl-pyrazolo[1,5-a]pyrimidine
CAS 889939-49-5C19H14ClN3O