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Murcko scaffold

Ring system with 4 rings and 25 atoms

101 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
101
With full pages
3
Scaffold SMILES

O=C1CCC(N2C(=O)c3ccc(N4CCCCC4)cc3C2=O)C(=O)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CCC(N2C(=O)c3ccc(N4CCCCC4)cc3C2=O)C(=O)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 101 chemicals

Thalidomide-4-piperidineacetaldehyde chemical structure, C20H21N3O5, CAS 2222115-36-6
Thalidomide-4-piperidineacetaldehyde
CAS 2222115-36-6C20H21N3O5
2-(2,6-Dioxopiperidin-3-yl)-5-(4-(hydroxymethyl)piperidin-1-yl)isoindoline-1,3-dione chemical structure, C19H21N3O5, CAS 2229717-49-9
2-(2,6-Dioxopiperidin-3-yl)-5-(4-(hydroxymethyl)piperidin-1-yl)isoindoline-1,3-dione
CAS 2229717-49-9C19H21N3O5
1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carbaldehyde chemical structure, C19H19N3O5, CAS 2241315-66-0
1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carbaldehyde
CAS 2241315-66-0C19H19N3O5
2-(2,6-Dioxopiperidin-3-yl)-5-(4-(2-hydroxyethyl)piperidin-1-yl)isoindoline-1,3-dione chemical structure, C20H23N3O5, CAS 2222115-35-5
2-(2,6-Dioxopiperidin-3-yl)-5-(4-(2-hydroxyethyl)piperidin-1-yl)isoindoline-1,3-dione
CAS 2222115-35-5C20H23N3O5
5-(4-Aminopiperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione chemical structure, C18H20N4O4, CAS 2636798-55-3
5-(4-Aminopiperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS 2636798-55-3C18H20N4O4
1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)piperidine-4-carboxylic acid chemical structure, C19H19N3O6, CAS 2467965-70-2
1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)piperidine-4-carboxylic acid
CAS 2467965-70-2C19H19N3O6
1-(2-(2,6-Dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidine-4-carbaldehyde chemical structure, C19H18FN3O5, CAS 2505502-00-9
1-(2-(2,6-Dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidine-4-carbaldehyde
CAS 2505502-00-9C19H18FN3O5
2-(2,6-Dioxopiperidin-3-yl)-5-fluoro-6-(4-(hydroxymethyl)piperidin-1-yl)isoindoline-1,3-dione chemical structure, C19H20FN3O5, CAS 2505501-99-3
2-(2,6-Dioxopiperidin-3-yl)-5-fluoro-6-(4-(hydroxymethyl)piperidin-1-yl)isoindoline-1,3-dione
CAS 2505501-99-3C19H20FN3O5
2-(2,6-Dioxopiperidin-3-yl)-5-(4-(methylamino)piperidin-1-yl)isoindoline-1,3-dione chemical structure, C19H22N4O4, CAS 2636798-53-1
2-(2,6-Dioxopiperidin-3-yl)-5-(4-(methylamino)piperidin-1-yl)isoindoline-1,3-dione
CAS 2636798-53-1C19H22N4O4
5-[4-(Aminomethyl)piperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C19H22N4O4, CAS 2636798-74-6
5-[4-(Aminomethyl)piperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2636798-74-6C19H22N4O4
Thalidomide-Pip-N-boc chemical structure, C23H28N4O6, CAS 2636798-54-2
Thalidomide-Pip-N-boc
CAS 2636798-54-2C23H28N4O6
2-(1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)acetic acid chemical structure, C20H21N3O6, CAS 2641511-94-4
2-(1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)acetic acid
CAS 2641511-94-4C20H21N3O6
5-[4-(2-Aminoethyl)piperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C20H24N4O4, CAS 2682113-78-4
5-[4-(2-Aminoethyl)piperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2682113-78-4C20H24N4O4
tert-Butyl 1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carboxylate chemical structure, C23H27N3O6, CAS 2688100-24-3
tert-Butyl 1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carboxylate
CAS 2688100-24-3C23H27N3O6
5-(4-Aminopiperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride chemical structure, C18H21ClN4O4, CAS 2636798-56-4
5-(4-Aminopiperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
CAS 2636798-56-4C18H21ClN4O4
2-(2,6-Dioxopiperidin-3-yl)-5-fluoro-6-(4-(2-hydroxyethyl)piperidin-1-yl)isoindoline-1,3-dione chemical structure, C20H22FN3O5, CAS 2837984-88-8
2-(2,6-Dioxopiperidin-3-yl)-5-fluoro-6-(4-(2-hydroxyethyl)piperidin-1-yl)isoindoline-1,3-dione
CAS 2837984-88-8C20H22FN3O5
5-[4-(2,2-Dimethoxyethyl)-1-piperidinyl]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione chemical structure, C22H27N3O6, CAS 2589698-86-0
5-[4-(2,2-Dimethoxyethyl)-1-piperidinyl]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
CAS 2589698-86-0C22H27N3O6
5-[4-(Aminomethyl)-4-fluoropiperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C19H21FN4O4, CAS 2703768-01-6
5-[4-(Aminomethyl)-4-fluoropiperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2703768-01-6C19H21FN4O4
5-(5-Amino-2-methylpiperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C19H22N4O4, CAS 2703765-44-8
5-(5-Amino-2-methylpiperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2703765-44-8C19H22N4O4
5-[2-(Aminomethyl)-5-methylpiperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C20H24N4O4, CAS 2703767-71-7
5-[2-(Aminomethyl)-5-methylpiperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2703767-71-7C20H24N4O4
rac-5-[(2R,4S)-2-(Aminomethyl)-4-methylpiperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C20H24N4O4, CAS 2731012-56-7
rac-5-[(2R,4S)-2-(Aminomethyl)-4-methylpiperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2731012-56-7C20H24N4O4
5-[3-(Aminomethyl)-4-(trifluoromethyl)piperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C20H21F3N4O4, CAS 2703760-56-7
5-[3-(Aminomethyl)-4-(trifluoromethyl)piperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2703760-56-7C20H21F3N4O4
5-[(3S,5S)-3-Amino-5-fluoropiperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C18H19FN4O4, CAS 2728766-21-8
5-[(3S,5S)-3-Amino-5-fluoropiperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2728766-21-8C18H19FN4O4
2-(2,6-Dioxopiperidin-3-yl)-5-[3-(methylamino)piperidin-1-yl]-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C19H22N4O4, CAS 2703771-42-8
2-(2,6-Dioxopiperidin-3-yl)-5-[3-(methylamino)piperidin-1-yl]-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2703771-42-8C19H22N4O4