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Murcko scaffold

2-(2,6-Dioxopiperidin-3-yl)-5-(piperazin-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione scaffold

77 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
77
With full pages
4
Scaffold SMILES

O=C1CCC(N2C(=O)c3ccc(N4CCNCC4)cc3C2=O)C(=O)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-(2,6-Dioxopiperidin-3-yl)-5-(piperazin-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione page
Murcko scaffold O=C1CCC(N2C(=O)c3ccc(N4CCNCC4)cc3C2=O)C(=O)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 77 chemicals

2-(2,6-Dioxopiperidin-3-yl)-5-(piperazin-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C17H18N4O4, CAS 2154342-61-5
2-(2,6-Dioxopiperidin-3-yl)-5-(piperazin-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2154342-61-5C17H18N4O4
2-(2,6-Dioxo-3-piperidinyl)-4-methoxy-6-(1-piperazinyl)-1H-isoindole-1,3(2H)-dione chemical structure, C18H20N4O5, CAS 2222114-91-0
2-(2,6-Dioxo-3-piperidinyl)-4-methoxy-6-(1-piperazinyl)-1H-isoindole-1,3(2H)-dione
CAS 2222114-91-0C18H20N4O5
tert-Butyl 4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazine-1-carboxylate chemical structure, C22H25FN4O6, CAS 2222116-02-9
tert-Butyl 4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazine-1-carboxylate
CAS 2222116-02-9C22H25FN4O6
2-(2,6-Dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-1-yl)isoindoline-1,3-dione chemical structure, C17H17FN4O4, CAS 2222114-22-7
2-(2,6-Dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-1-yl)isoindoline-1,3-dione
CAS 2222114-22-7C17H17FN4O4
Thalidomide-piperazine-Boc chemical structure, C22H26N4O6, CAS 2222114-64-7
Thalidomide-piperazine-Boc
CAS 2222114-64-7C22H26N4O6
Thalidomide-5'-piperazine-C2-OH chemical structure, C19H22N4O5, CAS 2222115-00-4
Thalidomide-5'-piperazine-C2-OH
CAS 2222115-00-4C19H22N4O5
Thalidomide-N-methylpiperazine chemical structure, C18H20N4O4, CAS 2924858-30-8
Thalidomide-N-methylpiperazine
CAS 2924858-30-8C18H20N4O4
2-(2,6-Dioxopiperidin-3-yl)-5-(3-methylpiperazin-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C18H20N4O4, CAS 2703771-46-2
2-(2,6-Dioxopiperidin-3-yl)-5-(3-methylpiperazin-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2703771-46-2C18H20N4O4
2-(2,6-Dioxopiperidin-3-yl)-5-(piperazin-1-yl)isoindoline-1,3-dione hydrochloride chemical structure, C17H19ClN4O4, CAS 2228029-82-9
2-(2,6-Dioxopiperidin-3-yl)-5-(piperazin-1-yl)isoindoline-1,3-dione hydrochloride
CAS 2228029-82-9C17H19ClN4O4
Thalidomide-Piperazine-PEG2-NH2 chemical structure, C23H31N5O6, CAS 2357110-14-4
Thalidomide-Piperazine-PEG2-NH2
CAS 2357110-14-4C23H31N5O6
Thalidomide-Piperazine-PEG1-NH2 chemical structure, C21H27N5O5, CAS 2357111-29-4
Thalidomide-Piperazine-PEG1-NH2
CAS 2357111-29-4C21H27N5O5
Thalidomide-Piperazine-PEG3-NH2 chemical structure, C25H35N5O7, CAS 2357113-68-7
Thalidomide-Piperazine-PEG3-NH2
CAS 2357113-68-7C25H35N5O7
2-(2,6-Dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride chemical structure, C17H18ClFN4O4, CAS 2222114-23-8
2-(2,6-Dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride
CAS 2222114-23-8C17H18ClFN4O4
2-(2,6-Dioxopiperidin-3-yl)-5-(piperazin-1-yl)isoindoline-1,3-dione dihydrochloride chemical structure, C17H20Cl2N4O4, CAS 2763758-54-7
2-(2,6-Dioxopiperidin-3-yl)-5-(piperazin-1-yl)isoindoline-1,3-dione dihydrochloride
CAS 2763758-54-7C17H20Cl2N4O4
2-(2,6-Dioxopiperidin-3-yl)-5-[(3R)-3-methylpiperazin-1-yl]-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C18H20N4O4, CAS 2728765-85-1
2-(2,6-Dioxopiperidin-3-yl)-5-[(3R)-3-methylpiperazin-1-yl]-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2728765-85-1C18H20N4O4
5-[4-(2-Azidoethyl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C19H21N7O4, CAS 2825005-43-2
5-[4-(2-Azidoethyl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2825005-43-2C19H21N7O4
2-(2,6-Dioxopiperidin-3-yl)-5-(4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)isoindoline-1,3-dione chemical structure, C21H26N4O6, CAS 2467424-27-5
2-(2,6-Dioxopiperidin-3-yl)-5-(4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)isoindoline-1,3-dione
CAS 2467424-27-5C21H26N4O6
5-[4-(2-Aminoethyl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C19H23N5O4, CAS 2467423-26-1
5-[4-(2-Aminoethyl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2467423-26-1C19H23N5O4
2-(2,6-Dioxopiperidin-3-yl)-5-[(3S)-3-methylpiperazin-1-yl]-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C18H20N4O4, CAS 2553108-25-9
2-(2,6-Dioxopiperidin-3-yl)-5-[(3S)-3-methylpiperazin-1-yl]-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2553108-25-9C18H20N4O4
5-(4-(2,2-Dimethoxyethyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione chemical structure, C21H26N4O6, CAS 2589699-10-3
5-(4-(2,2-Dimethoxyethyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS 2589699-10-3C21H26N4O6
(4-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)piperazin-1-yl)acetic acid chemical structure, C19H20N4O6, CAS 2591180-39-9
(4-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)piperazin-1-yl)acetic acid
CAS 2591180-39-9C19H20N4O6
1,1-Dimethylethyl 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazineacetate chemical structure, C23H28N4O6, CAS 2599846-17-8
1,1-Dimethylethyl 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazineacetate
CAS 2599846-17-8C23H28N4O6
tert-Butyl N-(6-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)piperazin-1-yl)hexyl)carbamate chemical structure, C28H39N5O6, CAS 2636798-36-0
tert-Butyl N-(6-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)piperazin-1-yl)hexyl)carbamate
CAS 2636798-36-0C28H39N5O6
5-[4-(6-Aminohexyl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C23H31N5O4, CAS 2636798-37-1
5-[4-(6-Aminohexyl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2636798-37-1C23H31N5O4