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Murcko scaffold

Ring system with 4 rings and 21 atoms

11 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
21
Chemicals
11
With full pages
2
Scaffold SMILES

c1ccc(-c2nc3ccc(N4CCNCC4)cc3[nH]2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2nc3ccc(N4CCNCC4)cc3[nH]2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

Hoechst 8208 chemical structure, C18H24Cl3N5, CAS 107882-63-3
Hoechst 8208
CAS 107882-63-3C18H24Cl3N5
Hoechst-8208 chemical structure, C18H21N5, CAS 77572-84-0
Hoechst-8208
CAS 77572-84-0C18H21N5
6-(4-Methyl-1-piperazinyl)-2-(3,4,5-trimethoxyphenyl)-1H-benzimidazole chemical structure, C21H26N4O3, CAS 685106-70-1
6-(4-Methyl-1-piperazinyl)-2-(3,4,5-trimethoxyphenyl)-1H-benzimidazole
CAS 685106-70-1C21H26N4O3
2-(3-Methoxyphenyl)-6-(4-methylpiperazino)-1H-1,3-benzimidazole chemical structure, C19H22N4O, CAS 865657-71-2
2-(3-Methoxyphenyl)-6-(4-methylpiperazino)-1H-1,3-benzimidazole
CAS 865657-71-2C19H22N4O
4-[6-(4-Methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2-nitrobenzenamine chemical structure, C18H20N6O2, CAS 23623-05-4
4-[6-(4-Methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2-nitrobenzenamine
CAS 23623-05-4C18H20N6O2
4-(6-(4-Methyl-1-piperazinyl)-1H-benzimidazol-2-yl)-1,2-benzenediamine chemical structure, C18H22N6, CAS 23491-49-8
4-(6-(4-Methyl-1-piperazinyl)-1H-benzimidazol-2-yl)-1,2-benzenediamine
CAS 23491-49-8C18H22N6
N-{4-[5-(4-Methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-2-nitrophenyl}acetamide chemical structure, C20H22N6O3, CAS 308362-09-6
N-{4-[5-(4-Methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-2-nitrophenyl}acetamide
CAS 308362-09-6C20H22N6O3
N-(3-Azidopropyl)-4-(2,6-di-tert-butyl-4-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)phenoxy)butanamide chemical structure, C33H48N8O2, CAS 1311982-88-3
N-(3-Azidopropyl)-4-(2,6-di-tert-butyl-4-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)phenoxy)butanamide
CAS 1311982-88-3C33H48N8O2
4-(6-(4-Methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)benzene-1,2-diamine trihydrochloride chemical structure, C18H25Cl3N6, CAS 1431697-77-6
4-(6-(4-Methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)benzene-1,2-diamine trihydrochloride
CAS 1431697-77-6C18H25Cl3N6
Butanoic acid, 4-[2,6-bis(1,1-dimethylethyl)-4-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]phenoxy]-, ethyl ester chemical structure, C32H46N4O3, CAS 1311982-92-9
Butanoic acid, 4-[2,6-bis(1,1-dimethylethyl)-4-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]phenoxy]-, ethyl ester
CAS 1311982-92-9C32H46N4O3
4-(2,6-di-tert-Butyl-4-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazoL-2-yl)phenoxy)butanoic acid chemical structure, C30H42N4O3, CAS 1311982-93-0
4-(2,6-di-tert-Butyl-4-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazoL-2-yl)phenoxy)butanoic acid
CAS 1311982-93-0C30H42N4O3