CompoundList
Sign in
Murcko scaffold

Ring system with 3 rings and 18 atoms

26 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
26
With full pages
5
Scaffold SMILES

O=C1C(=O)C2(C(=O)Nc3ccccc3)CCC1C2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(=O)C2(C(=O)Nc3ccccc3)CCC1C2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

N-(4-Acetylphenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C19H21NO4, CAS 1212483-85-6
N-(4-Acetylphenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide
CAS 1212483-85-6C19H21NO4
N-(2-Chlorophenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C17H18ClNO3, CAS 585556-55-4
N-(2-Chlorophenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide
CAS 585556-55-4C17H18ClNO3
N-{4-[(Difluoromethyl)sulfanyl]phenyl}-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C18H19F2NO3S, CAS 573938-58-6
N-{4-[(Difluoromethyl)sulfanyl]phenyl}-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide
CAS 573938-58-6C18H19F2NO3S
N-(4-Chloro-2-methylphenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C18H20ClNO3, CAS 622356-01-8
N-(4-Chloro-2-methylphenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide
CAS 622356-01-8C18H20ClNO3
4,7,7-Trimethyl-2,3-dioxo-N-(2-(trifluoromethyl)phenyl)bicyclo[2.2.1]heptane-1-carboxamide chemical structure, C18H18F3NO3, CAS 622355-89-9
4,7,7-Trimethyl-2,3-dioxo-N-(2-(trifluoromethyl)phenyl)bicyclo[2.2.1]heptane-1-carboxamide
CAS 622355-89-9C18H18F3NO3
N-(2,5-Dimethylphenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C19H23NO3, CAS 622356-07-4
N-(2,5-Dimethylphenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide
CAS 622356-07-4C19H23NO3
N-(4-Butylphenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C21H27NO3, CAS 622355-31-1
N-(4-Butylphenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide
CAS 622355-31-1C21H27NO3
N-(2-Methoxy-5-methylphenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C19H23NO4, CAS 622355-55-9
N-(2-Methoxy-5-methylphenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide
CAS 622355-55-9C19H23NO4
Dimethyl 5-(4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamido)isophthalate chemical structure, C21H23NO7, CAS 622356-17-6
Dimethyl 5-(4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamido)isophthalate
CAS 622356-17-6C21H23NO7
7,7-Dimethyl-2,3-dioxo-N-phenylbicyclo[2.2.1]heptane-1-carboxamide chemical structure, C16H17NO3, CAS 714210-09-0
7,7-Dimethyl-2,3-dioxo-N-phenylbicyclo[2.2.1]heptane-1-carboxamide
CAS 714210-09-0C16H17NO3
N-(2-Fluorophenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C17H18FNO3, CAS 728028-67-9
N-(2-Fluorophenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide
CAS 728028-67-9C17H18FNO3
N-(4-Ethylphenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C19H23NO3, CAS 622355-77-5
N-(4-Ethylphenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide
CAS 622355-77-5C19H23NO3
Isobutyl 4-(4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamido)benzoate chemical structure, C22H27NO5, CAS 616214-50-7
Isobutyl 4-(4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamido)benzoate
CAS 616214-50-7C22H27NO5
N-[5-(Dimethylsulfamoyl)-2-methylphenyl]-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C20H26N2O5S, CAS 622356-36-9
N-[5-(Dimethylsulfamoyl)-2-methylphenyl]-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide
CAS 622356-36-9C20H26N2O5S
N-(3-Chloro-2-methylphenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C18H20ClNO3, CAS 622355-86-6
N-(3-Chloro-2-methylphenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide
CAS 622355-86-6C18H20ClNO3
Bicyclo[2.2.1]heptane-1-carboxamide, N-(2,5-difluorophenyl)-4,7,7-trimethyl-2,3-dioxo- chemical structure, C17H17F2NO3, CAS 727686-11-5
Bicyclo[2.2.1]heptane-1-carboxamide, N-(2,5-difluorophenyl)-4,7,7-trimethyl-2,3-dioxo-
CAS 727686-11-5C17H17F2NO3
N-(4-Fluorophenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C17H18FNO3, CAS 727686-09-1
N-(4-Fluorophenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide
CAS 727686-09-1C17H18FNO3
7,7-Dimethyl-2,3-dioxo-N-[3-(trifluoromethyl)phenyl]bicyclo[2.2.1]heptane-1-carboxamide chemical structure, C17H16F3NO3, CAS 728028-71-5
7,7-Dimethyl-2,3-dioxo-N-[3-(trifluoromethyl)phenyl]bicyclo[2.2.1]heptane-1-carboxamide
CAS 728028-71-5C17H16F3NO3
N-(2-Fluorophenyl)-7,7-dimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C16H16FNO3, CAS 728028-68-0
N-(2-Fluorophenyl)-7,7-dimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide
CAS 728028-68-0C16H16FNO3
N-(4-Fluorophenyl)-7,7-dimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C16H16FNO3, CAS 728028-72-6
N-(4-Fluorophenyl)-7,7-dimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide
CAS 728028-72-6C16H16FNO3
7,7-Dimethyl-2,3-dioxo-N-[2-(trifluoromethyl)phenyl]bicyclo[2.2.1]heptane-1-carboxamide chemical structure, C17H16F3NO3, CAS 728028-70-4
7,7-Dimethyl-2,3-dioxo-N-[2-(trifluoromethyl)phenyl]bicyclo[2.2.1]heptane-1-carboxamide
CAS 728028-70-4C17H16F3NO3
N-(5-Chloro-2-methylphenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C18H20ClNO3, CAS 622356-11-0
N-(5-Chloro-2-methylphenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide
CAS 622356-11-0C18H20ClNO3
4,7,7-Trimethyl-2,3-dioxo-N-[4-(trifluoromethoxy)phenyl]bicyclo[2.2.1]heptane-1-carboxamide chemical structure, C18H18F3NO4, CAS 727686-10-4
4,7,7-Trimethyl-2,3-dioxo-N-[4-(trifluoromethoxy)phenyl]bicyclo[2.2.1]heptane-1-carboxamide
CAS 727686-10-4C18H18F3NO4
(1R,4S)-N-(2,4-Dimethoxyphenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C19H23NO5, CAS 898647-17-1
(1R,4S)-N-(2,4-Dimethoxyphenyl)-4,7,7-trimethyl-2,3-dioxobicyclo[2.2.1]heptane-1-carboxamide
CAS 898647-17-1C19H23NO5