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Murcko scaffold

Ring system with 3 rings and 17 atoms

56 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
56
With full pages
12
Scaffold SMILES

O=C1CC2(C(=O)Nc3ccccc3)CCC1C2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC2(C(=O)Nc3ccccc3)CCC1C2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 56 chemicals

N-(2,3-Dichlorophenyl)-1,7,7-trimethyl-2-oxobicyclo[2.2.1]heptane-4-carboxamide chemical structure, C17H19Cl2NO2, CAS 385786-81-2
N-(2,3-Dichlorophenyl)-1,7,7-trimethyl-2-oxobicyclo[2.2.1]heptane-4-carboxamide
CAS 385786-81-2C17H19Cl2NO2
4,7,7-Trimethyl-3-oxo-N-phenylbicyclo[2.2.1]heptane-1-carboxamide chemical structure, C17H21NO2, CAS 385786-98-1
4,7,7-Trimethyl-3-oxo-N-phenylbicyclo[2.2.1]heptane-1-carboxamide
CAS 385786-98-1C17H21NO2
N-(2,4-Dimethyl-6-nitrophenyl)-1,7,7-trimethyl-2-oxobicyclo[2.2.1]heptane-4-carboxamide chemical structure, C19H24N2O4, CAS 433687-90-2
N-(2,4-Dimethyl-6-nitrophenyl)-1,7,7-trimethyl-2-oxobicyclo[2.2.1]heptane-4-carboxamide
CAS 433687-90-2C19H24N2O4
Propyl 3-{[(4,7,7-trimethyl-3-oxobicyclo[2.2.1]hept-1-yl)carbonyl]amino}benzoate chemical structure, C21H27NO4, CAS 1212473-14-7
Propyl 3-{[(4,7,7-trimethyl-3-oxobicyclo[2.2.1]hept-1-yl)carbonyl]amino}benzoate
CAS 1212473-14-7C21H27NO4
(1S,4S)-N-(2-Fluorophenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C17H20FNO2, CAS 433688-68-7
(1S,4S)-N-(2-Fluorophenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide
CAS 433688-68-7C17H20FNO2
Methyl 4-{[(4,7,7-trimethyl-3-oxobicyclo[2.2.1]hept-1-yl)carbonyl]amino}benzoate chemical structure, C19H23NO4, CAS 385786-77-6
Methyl 4-{[(4,7,7-trimethyl-3-oxobicyclo[2.2.1]hept-1-yl)carbonyl]amino}benzoate
CAS 385786-77-6C19H23NO4
Methyl 2-{[(4,7,7-trimethyl-3-oxobicyclo[2.2.1]hept-1-yl)carbonyl]amino}benzoate chemical structure, C19H23NO4, CAS 1212478-29-9
Methyl 2-{[(4,7,7-trimethyl-3-oxobicyclo[2.2.1]hept-1-yl)carbonyl]amino}benzoate
CAS 1212478-29-9C19H23NO4
N-(2,5-Dichlorophenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C17H19Cl2NO2, CAS 385786-82-3
N-(2,5-Dichlorophenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide
CAS 385786-82-3C17H19Cl2NO2
(1S,4S)-N-(4-Acetylphenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C19H23NO3, CAS 385786-76-5
(1S,4S)-N-(4-Acetylphenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide
CAS 385786-76-5C19H23NO3
N-(2-Bromophenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C17H20BrNO2, CAS 1212427-10-5
N-(2-Bromophenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide
CAS 1212427-10-5C17H20BrNO2
N-(3,4-Dichlorophenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C17H19Cl2NO2, CAS 385786-83-4
N-(3,4-Dichlorophenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide
CAS 385786-83-4C17H19Cl2NO2
N-(4-Iodophenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C17H20INO2, CAS 505060-72-0
N-(4-Iodophenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide
CAS 505060-72-0C17H20INO2
N-(4-Methoxyphenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C18H23NO3, CAS 505060-73-1
N-(4-Methoxyphenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide
CAS 505060-73-1C18H23NO3
Ethyl 4-((1S,4S)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamido)benzoate chemical structure, C20H25NO4, CAS 539808-05-4
Ethyl 4-((1S,4S)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamido)benzoate
CAS 539808-05-4C20H25NO4
N-(4-Fluorophenyl)-1,7,7-trimethyl-2-oxobicyclo[2.2.1]heptane-4-carboxamide chemical structure, C17H20FNO2, CAS 577767-10-3
N-(4-Fluorophenyl)-1,7,7-trimethyl-2-oxobicyclo[2.2.1]heptane-4-carboxamide
CAS 577767-10-3C17H20FNO2
N-(2-Methoxyphenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C18H23NO3, CAS 573669-14-4
N-(2-Methoxyphenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide
CAS 573669-14-4C18H23NO3
1,7,7-Trimethyl-N-(3-nitrophenyl)-2-oxobicyclo[2.2.1]heptane-4-carboxamide chemical structure, C17H20N2O4, CAS 637755-18-1
1,7,7-Trimethyl-N-(3-nitrophenyl)-2-oxobicyclo[2.2.1]heptane-4-carboxamide
CAS 637755-18-1C17H20N2O4
N-(4-Ethoxyphenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C19H25NO3, CAS 637755-19-2
N-(4-Ethoxyphenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide
CAS 637755-19-2C19H25NO3
N-(3,4-Dimethylphenyl)-1,7,7-trimethyl-2-oxobicyclo[2.2.1]heptane-4-carboxamide chemical structure, C19H25NO2, CAS 618403-05-7
N-(3,4-Dimethylphenyl)-1,7,7-trimethyl-2-oxobicyclo[2.2.1]heptane-4-carboxamide
CAS 618403-05-7C19H25NO2
N-(2,5-Dimethylphenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C19H25NO2, CAS 618403-18-2
N-(2,5-Dimethylphenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide
CAS 618403-18-2C19H25NO2
N-(5-Chloro-2-methylphenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C18H22ClNO2, CAS 618403-22-8
N-(5-Chloro-2-methylphenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide
CAS 618403-22-8C18H22ClNO2
N-(5-Chloro-2-methoxyphenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide chemical structure, C18H22ClNO3, CAS 618403-01-3
N-(5-Chloro-2-methoxyphenyl)-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-1-carboxamide
CAS 618403-01-3C18H22ClNO3
N-(2-Ethylphenyl)-1,7,7-trimethyl-2-oxobicyclo[2.2.1]heptane-4-carboxamide chemical structure, C19H25NO2, CAS 618402-57-6
N-(2-Ethylphenyl)-1,7,7-trimethyl-2-oxobicyclo[2.2.1]heptane-4-carboxamide
CAS 618402-57-6C19H25NO2
N-(3,5-Dimethylphenyl)-1,7,7-trimethyl-2-oxobicyclo[2.2.1]heptane-4-carboxamide chemical structure, C19H25NO2, CAS 618402-04-3
N-(3,5-Dimethylphenyl)-1,7,7-trimethyl-2-oxobicyclo[2.2.1]heptane-4-carboxamide
CAS 618402-04-3C19H25NO2