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Murcko scaffold

4-Phenyl-3,4-dihydroquinolin-2(1H)-one scaffold

103 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
103
With full pages
19
Scaffold SMILES

O=C1CC(c2ccccc2)c2ccccc2N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-Phenyl-3,4-dihydroquinolin-2(1H)-one page
Murcko scaffold O=C1CC(c2ccccc2)c2ccccc2N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 103 chemicals

4-Phenyl-3,4-dihydroquinolin-2(1H)-one chemical structure, C15H13NO, CAS 4888-33-9
4-Phenyl-3,4-dihydroquinolin-2(1H)-one
CAS 4888-33-9C15H13NO
4-(2-Chlorophenyl)-6,7-dimethyl-3,4-dihydroquinolin-2(1H)-one chemical structure, C17H16ClNO, CAS 347315-68-8
4-(2-Chlorophenyl)-6,7-dimethyl-3,4-dihydroquinolin-2(1H)-one
CAS 347315-68-8C17H16ClNO
4-[2-(Trifluoromethyl)phenyl]-3,4-dihydro-1H-quinolin-2-one chemical structure, C16H12F3NO, CAS 312622-37-0
4-[2-(Trifluoromethyl)phenyl]-3,4-dihydro-1H-quinolin-2-one
CAS 312622-37-0C16H12F3NO
4-(2-Bromophenyl)-6-methyl-3,4-dihydroquinolin-2(1H)-one chemical structure, C16H14BrNO, CAS 304451-48-7
4-(2-Bromophenyl)-6-methyl-3,4-dihydroquinolin-2(1H)-one
CAS 304451-48-7C16H14BrNO
RefChem:381443 chemical structure, C16H14N2O3, CAS 6048-11-9
RefChem:381443
CAS 6048-11-9C16H14N2O3
4-(2-Chlorophenyl)-6-methyl-3,4-dihydroquinolin-2(1H)-one chemical structure, C16H14ClNO, CAS 306752-21-6
4-(2-Chlorophenyl)-6-methyl-3,4-dihydroquinolin-2(1H)-one
CAS 306752-21-6C16H14ClNO
6-Ethoxy-4-[2-(trifluoromethyl)phenyl]-3,4-dihydro-1H-quinolin-2-one chemical structure, C18H16F3NO2, CAS 312622-33-6
6-Ethoxy-4-[2-(trifluoromethyl)phenyl]-3,4-dihydro-1H-quinolin-2-one
CAS 312622-33-6C18H16F3NO2
4-(2-Nitrophenyl)-3,4-dihydroquinolin-2(1H)-one chemical structure, C15H12N2O3, CAS 67101-94-4
4-(2-Nitrophenyl)-3,4-dihydroquinolin-2(1H)-one
CAS 67101-94-4C15H12N2O3
4-(2-Ethoxyphenyl)-6,7-dimethyl-3,4-dihydro-1H-quinolin-2-one chemical structure, C19H21NO2, CAS 347351-98-8
4-(2-Ethoxyphenyl)-6,7-dimethyl-3,4-dihydro-1H-quinolin-2-one
CAS 347351-98-8C19H21NO2
6,7-Dimethyl-4-(3,4,5-trimethoxyphenyl)-3,4-dihydroquinolin-2(1H)-one chemical structure, C20H23NO4, CAS 347351-90-0
6,7-Dimethyl-4-(3,4,5-trimethoxyphenyl)-3,4-dihydroquinolin-2(1H)-one
CAS 347351-90-0C20H23NO4
4-(2-Bromophenyl)-6,7-dimethyl-3,4-dihydroquinolin-2(1H)-one chemical structure, C17H16BrNO, CAS 347313-94-4
4-(2-Bromophenyl)-6,7-dimethyl-3,4-dihydroquinolin-2(1H)-one
CAS 347313-94-4C17H16BrNO
4-(2,5-Difluorophenyl)-6,7-dimethyl-3,4-dihydro-1H-quinolin-2-one chemical structure, C17H15F2NO, CAS 347326-41-4
4-(2,5-Difluorophenyl)-6,7-dimethyl-3,4-dihydro-1H-quinolin-2-one
CAS 347326-41-4C17H15F2NO
4-(2,3-Dichlorophenyl)-6,7-dimethyl-3,4-dihydroquinolin-2(1H)-one chemical structure, C17H15Cl2NO, CAS 347324-10-1
4-(2,3-Dichlorophenyl)-6,7-dimethyl-3,4-dihydroquinolin-2(1H)-one
CAS 347324-10-1C17H15Cl2NO
4-(4-Chloro-3-nitrophenyl)-6,7-dimethyl-3,4-dihydro-1H-quinolin-2-one chemical structure, C17H15ClN2O3, CAS 347352-04-9
4-(4-Chloro-3-nitrophenyl)-6,7-dimethyl-3,4-dihydro-1H-quinolin-2-one
CAS 347352-04-9C17H15ClN2O3
6,7-Dimethyl-4-(2-methylphenyl)-3,4-dihydroquinolin-2(1H)-one chemical structure, C18H19NO, CAS 347328-40-9
6,7-Dimethyl-4-(2-methylphenyl)-3,4-dihydroquinolin-2(1H)-one
CAS 347328-40-9C18H19NO
4-(3,4-Dichlorophenyl)-6,7-dimethyl-3,4-dihydroquinolin-2(1H)-one chemical structure, C17H15Cl2NO, CAS 347328-34-1
4-(3,4-Dichlorophenyl)-6,7-dimethyl-3,4-dihydroquinolin-2(1H)-one
CAS 347328-34-1C17H15Cl2NO
4-(4-Fluorophenyl)-6,7-dimethyl-3,4-dihydroquinolin-2(1H)-one chemical structure, C17H16FNO, CAS 347325-20-6
4-(4-Fluorophenyl)-6,7-dimethyl-3,4-dihydroquinolin-2(1H)-one
CAS 347325-20-6C17H16FNO
6-Bromo-4-(2-chlorophenyl)-3-(diethylamino)-3,4-dihydroquinolin-2(1H)-one chemical structure, C19H20BrClN2O, CAS 1007982-78-6
6-Bromo-4-(2-chlorophenyl)-3-(diethylamino)-3,4-dihydroquinolin-2(1H)-one
CAS 1007982-78-6C19H20BrClN2O
4-(3-Bromo-5-ethoxy-4-hydroxyphenyl)-6,7-dimethyl-3,4-dihydroquinolin-2(1H)-one chemical structure, C19H20BrNO3, CAS 433244-53-2
4-(3-Bromo-5-ethoxy-4-hydroxyphenyl)-6,7-dimethyl-3,4-dihydroquinolin-2(1H)-one
CAS 433244-53-2C19H20BrNO3
4-(2-Butoxyphenyl)-6,7-dimethyl-3,4-dihydroquinolin-2(1H)-one chemical structure, C21H25NO2, CAS 433241-62-4
4-(2-Butoxyphenyl)-6,7-dimethyl-3,4-dihydroquinolin-2(1H)-one
CAS 433241-62-4C21H25NO2
4-(2,5-Dimethylphenyl)-6,7-dimethyl-3,4-dihydro-1H-quinolin-2-one chemical structure, C19H21NO, CAS 433250-56-7
4-(2,5-Dimethylphenyl)-6,7-dimethyl-3,4-dihydro-1H-quinolin-2-one
CAS 433250-56-7C19H21NO
6-Chloro-3-(diethylamino)-4-phenyl-3,4-dihydro-1H-quinolin-2-one chemical structure, C19H21ClN2O, CAS 672893-01-5
6-Chloro-3-(diethylamino)-4-phenyl-3,4-dihydro-1H-quinolin-2-one
CAS 672893-01-5C19H21ClN2O
4-(3-Ethoxyphenyl)-6,7-dimethoxy-3,4-dihydro-1H-quinolin-2-one chemical structure, C19H21NO4, CAS 599150-94-4
4-(3-Ethoxyphenyl)-6,7-dimethoxy-3,4-dihydro-1H-quinolin-2-one
CAS 599150-94-4C19H21NO4
3,4-Dihydro-6,7-dimethoxy-4-(2-(trifluoromethyl)phenyl)-2(1H)-quinolinone chemical structure, C18H16F3NO3, CAS 599151-36-7
3,4-Dihydro-6,7-dimethoxy-4-(2-(trifluoromethyl)phenyl)-2(1H)-quinolinone
CAS 599151-36-7C18H16F3NO3