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Murcko scaffold

Ring system with 2 rings and 17 atoms

11 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
17
Chemicals
11
With full pages
3
Scaffold SMILES

O=C(C=Cc1cccs1)NCc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1cccs1)NCc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

(E)-N-[(4-Sulfamoylphenyl)methyl]-3-thiophen-2-ylprop-2-enamide chemical structure, C14H14N2O3S2, CAS 545358-58-5
(E)-N-[(4-Sulfamoylphenyl)methyl]-3-thiophen-2-ylprop-2-enamide
CAS 545358-58-5C14H14N2O3S2
(E)-N-[(4-Fluorophenyl)methyl]-3-thiophen-2-ylprop-2-enamide chemical structure, C14H12FNOS, CAS 550315-41-8
(E)-N-[(4-Fluorophenyl)methyl]-3-thiophen-2-ylprop-2-enamide
CAS 550315-41-8C14H12FNOS
n-Benzyl-2-cyano-3-(thiophen-2-yl)prop-2-enamide chemical structure, C15H12N2OS, CAS 306312-59-4
n-Benzyl-2-cyano-3-(thiophen-2-yl)prop-2-enamide
CAS 306312-59-4C15H12N2OS
(E)-N-Benzyl-3-(thiophen-2-yl)acrylamide chemical structure, C14H13NOS, CAS 1061323-61-2
(E)-N-Benzyl-3-(thiophen-2-yl)acrylamide
CAS 1061323-61-2C14H13NOS
N-Benzyl-3-(5-bromothiophen-2-yl)-2-cyanoprop-2-enamide chemical structure, C15H11BrN2OS, CAS 355817-02-6
N-Benzyl-3-(5-bromothiophen-2-yl)-2-cyanoprop-2-enamide
CAS 355817-02-6C15H11BrN2OS
N-[(4-Chlorophenyl)methyl]-2-cyano-3-(3-methylthiophen-2-yl)prop-2-enamide chemical structure, C16H13ClN2OS, CAS 717826-36-3
N-[(4-Chlorophenyl)methyl]-2-cyano-3-(3-methylthiophen-2-yl)prop-2-enamide
CAS 717826-36-3C16H13ClN2OS
(2E)-2-Cyano-N-(1-phenylethyl)-3-(thiophen-2-yl)prop-2-enamide chemical structure, C16H14N2OS, CAS 365442-91-7
(2E)-2-Cyano-N-(1-phenylethyl)-3-(thiophen-2-yl)prop-2-enamide
CAS 365442-91-7C16H14N2OS
(2Z)-2-Cyano-N-[1-(2,5-dimethylphenyl)ethyl]-3-(3-methylthiophen-2-yl)prop-2-enamide chemical structure, C19H20N2OS, CAS 724782-69-8
(2Z)-2-Cyano-N-[1-(2,5-dimethylphenyl)ethyl]-3-(3-methylthiophen-2-yl)prop-2-enamide
CAS 724782-69-8C19H20N2OS
N-Benzyl-3-(4-bromothiophen-2-yl)-2-cyanoprop-2-enamide chemical structure, C15H11BrN2OS, CAS 941023-52-5
N-Benzyl-3-(4-bromothiophen-2-yl)-2-cyanoprop-2-enamide
CAS 941023-52-5C15H11BrN2OS
(E)-N-Benzyl-3-(5-nitrothiophen-2-yl)acrylamide chemical structure, C14H12N2O3S, CAS 1061323-57-6
(E)-N-Benzyl-3-(5-nitrothiophen-2-yl)acrylamide
CAS 1061323-57-6C14H12N2O3S
2-Propenamide, N-[[4-(1-methylethoxy)phenyl]methyl]-3-(2-thienyl)- chemical structure, C17H19NO2S, CAS 1071365-51-9
2-Propenamide, N-[[4-(1-methylethoxy)phenyl]methyl]-3-(2-thienyl)-
CAS 1071365-51-9C17H19NO2S