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Murcko scaffold

Ring system with 3 rings and 20 atoms

15 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
15
With full pages
5
Scaffold SMILES

O=C(Nc1ccccc1)c1scnc1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)c1scnc1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

2-Amino-N-(4-methoxyphenyl)-4-phenyl-1,3-thiazole-5-carboxamide chemical structure, C17H15N3O2S, CAS 380179-86-2
2-Amino-N-(4-methoxyphenyl)-4-phenyl-1,3-thiazole-5-carboxamide
CAS 380179-86-2C17H15N3O2S
2-Amino-N,4-diphenylthiazole-5-carboxamide chemical structure, C16H13N3OS, CAS 300815-19-4
2-Amino-N,4-diphenylthiazole-5-carboxamide
CAS 300815-19-4C16H13N3OS
2-Amino-N-(3,4-dimethylphenyl)-4-phenyl-1,3-thiazole-5-carboxamide chemical structure, C18H17N3OS, CAS 315677-43-1
2-Amino-N-(3,4-dimethylphenyl)-4-phenyl-1,3-thiazole-5-carboxamide
CAS 315677-43-1C18H17N3OS
2-Amino-N-(2,6-dimethylphenyl)-4-phenyl-1,3-thiazole-5-carboxamide chemical structure, C18H17N3OS, CAS 379244-09-4
2-Amino-N-(2,6-dimethylphenyl)-4-phenyl-1,3-thiazole-5-carboxamide
CAS 379244-09-4C18H17N3OS
2-Amino-N-(3-chloro-4-fluorophenyl)-4-phenyl-1,3-thiazole-5-carboxamide chemical structure, C16H11ClFN3OS, CAS 379244-26-5
2-Amino-N-(3-chloro-4-fluorophenyl)-4-phenyl-1,3-thiazole-5-carboxamide
CAS 379244-26-5C16H11ClFN3OS
2-Chloro-N-(2-methoxyphenyl)-4-phenyl-1,3-thiazole-5-carboxamide chemical structure, C17H13ClN2O2S, CAS 724434-76-8
2-Chloro-N-(2-methoxyphenyl)-4-phenyl-1,3-thiazole-5-carboxamide
CAS 724434-76-8C17H13ClN2O2S
2-Methyl-N-(3-methylphenyl)-4-(4-nitrophenyl)-1,3-thiazole-5-carboxamide chemical structure, C18H15N3O3S, CAS 294668-21-6
2-Methyl-N-(3-methylphenyl)-4-(4-nitrophenyl)-1,3-thiazole-5-carboxamide
CAS 294668-21-6C18H15N3O3S
N-(3-Methoxyphenyl)-2-methyl-4-(4-nitrophenyl)-1,3-thiazole-5-carboxamide chemical structure, C18H15N3O4S, CAS 303793-12-6
N-(3-Methoxyphenyl)-2-methyl-4-(4-nitrophenyl)-1,3-thiazole-5-carboxamide
CAS 303793-12-6C18H15N3O4S
2-Amino-N-(3-methoxyphenyl)-4-phenyl-1,3-thiazole-5-carboxamide chemical structure, C17H15N3O2S, CAS 298193-87-0
2-Amino-N-(3-methoxyphenyl)-4-phenyl-1,3-thiazole-5-carboxamide
CAS 298193-87-0C17H15N3O2S
2-(Allylamino)-4-(4-nitrophenyl)-N-phenylthiazole-5-carboxamide chemical structure, C19H16N4O3S, CAS 301331-68-0
2-(Allylamino)-4-(4-nitrophenyl)-N-phenylthiazole-5-carboxamide
CAS 301331-68-0C19H16N4O3S
N-(3,4-Dimethylphenyl)-4-phenyl-2-(prop-2-enylamino)-1,3-thiazole-5-carboxamide chemical structure, C21H21N3OS, CAS 315677-44-2
N-(3,4-Dimethylphenyl)-4-phenyl-2-(prop-2-enylamino)-1,3-thiazole-5-carboxamide
CAS 315677-44-2C21H21N3OS
N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-methyl-4-phenyl-1,3-thiazole-5-carboxamide chemical structure, C18H12ClF3N2OS, CAS 315682-93-0
N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-methyl-4-phenyl-1,3-thiazole-5-carboxamide
CAS 315682-93-0C18H12ClF3N2OS
2-((E)-((Dimethylamino)methylene)amino)-N-(4-((E)-N-((dimethylamino)methylene)sulfamoyl)phenyl)-4-(4-nitrophenyl)thiazole-5-carboxamide chemical structure, C22H23N7O5S2, CAS 304684-39-7
2-((E)-((Dimethylamino)methylene)amino)-N-(4-((E)-N-((dimethylamino)methylene)sulfamoyl)phenyl)-4-(4-nitrophenyl)thiazole-5-carboxamide
CAS 304684-39-7C22H23N7O5S2
(E)-Diethyl 2-(((4-phenyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)thiazol-2-yl)imino)methyl)malonate chemical structure, C25H22F3N3O5S, CAS 304863-78-3
(E)-Diethyl 2-(((4-phenyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)thiazol-2-yl)imino)methyl)malonate
CAS 304863-78-3C25H22F3N3O5S
2-Bromo-N-(4-bromophenyl)-4-(4-methoxyphenyl)-5-thiazolecarboxamide chemical structure, C17H12Br2N2O2S, CAS 218631-56-2
2-Bromo-N-(4-bromophenyl)-4-(4-methoxyphenyl)-5-thiazolecarboxamide
CAS 218631-56-2C17H12Br2N2O2S