Murcko scaffold
Ring system with 3 rings and 21 atoms
128 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 21
- Chemicals
- 128
- With full pages
- 7
Scaffold SMILES
O=S(=O)(Nc1ccccc1)c1cscc1-c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 128 chemicals
![3-{[Methyl(4-methylphenyl)amino]sulfonyl}-4-phenylthiophene-2-carboxylic acid chemical structure, C19H17NO4S2, CAS 931314-32-8](/s/FRZFQXZAMFFTCQ-UHFFFAOYSA-N.svg)
3-{[Methyl(4-methylphenyl)amino]sulfonyl}-4-phenylthiophene-2-carboxylic acid
CAS 931314-32-8C19H17NO4S2
![Methyl 3-[ethyl(phenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C21H21NO4S2, CAS 941936-22-7](/s/GSMCOPLVPLVZIP-UHFFFAOYSA-N.svg)
Methyl 3-[ethyl(phenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 941936-22-7C21H21NO4S2
![Methyl 3-[(4-acetamidophenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C21H20N2O5S2, CAS 941979-17-5](/s/PNOGBSWRICKKFJ-UHFFFAOYSA-N.svg)
Methyl 3-[(4-acetamidophenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 941979-17-5C21H20N2O5S2
![Methyl 3-{[2-(ethoxycarbonyl)phenyl]sulfamoyl}-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C22H21NO6S2, CAS 941936-28-3](/s/XKKWIMATPOVQNW-UHFFFAOYSA-N.svg)
Methyl 3-{[2-(ethoxycarbonyl)phenyl]sulfamoyl}-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 941936-28-3C22H21NO6S2
![Methyl 4-(4-methylphenyl)-3-[(2,4,6-trimethylphenyl)sulfamoyl]thiophene-2-carboxylate chemical structure, C22H23NO4S2, CAS 941979-20-0](/s/FDPDJKHLFHJAEZ-UHFFFAOYSA-N.svg)
Methyl 4-(4-methylphenyl)-3-[(2,4,6-trimethylphenyl)sulfamoyl]thiophene-2-carboxylate
CAS 941979-20-0C22H23NO4S2
![Methyl 3-[(4-ethylphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate chemical structure, C20H19NO4S2, CAS 895263-37-3](/s/HQSLYRSPNQHXET-UHFFFAOYSA-N.svg)
Methyl 3-[(4-ethylphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate
CAS 895263-37-3C20H19NO4S2
![Methyl 3-[(3-chloro-4-methylphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate chemical structure, C19H16ClNO4S2, CAS 895263-65-7](/s/ZRKCTFVZGHHAHC-UHFFFAOYSA-N.svg)
Methyl 3-[(3-chloro-4-methylphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate
CAS 895263-65-7C19H16ClNO4S2
![Methyl 3-[(2,3-dimethylphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate chemical structure, C20H19NO4S2, CAS 895263-79-3](/s/QUNLVGIQQCSWKU-UHFFFAOYSA-N.svg)
Methyl 3-[(2,3-dimethylphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate
CAS 895263-79-3C20H19NO4S2
![Ethyl 3-[(2-fluorophenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate chemical structure, C19H16FNO4S2, CAS 941935-47-3](/s/IRTYUUHWFLXCBQ-UHFFFAOYSA-N.svg)
Ethyl 3-[(2-fluorophenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate
CAS 941935-47-3C19H16FNO4S2
![Ethyl 3-[(5-chloro-2,4-dimethoxyphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate chemical structure, C21H20ClNO6S2, CAS 941888-39-7](/s/JVSSOUWMKFDWOW-UHFFFAOYSA-N.svg)
Ethyl 3-[(5-chloro-2,4-dimethoxyphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate
CAS 941888-39-7C21H20ClNO6S2
![Ethyl 3-[(3,5-dimethoxyphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate chemical structure, C21H21NO6S2, CAS 941978-40-1](/s/ATYMRZMHVDMGEQ-UHFFFAOYSA-N.svg)
Ethyl 3-[(3,5-dimethoxyphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate
CAS 941978-40-1C21H21NO6S2
![Methyl 3-[(2-methoxy-5-methylphenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C21H21NO5S2, CAS 941935-57-5](/s/FLVSYSQCTHMWMM-UHFFFAOYSA-N.svg)
Methyl 3-[(2-methoxy-5-methylphenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 941935-57-5C21H21NO5S2
![Methyl 3-[(4-chloro-2-methoxy-5-methylphenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C21H20ClNO5S2, CAS 941888-49-9](/s/JSKMAZARQKNGOU-UHFFFAOYSA-N.svg)
Methyl 3-[(4-chloro-2-methoxy-5-methylphenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 941888-49-9C21H20ClNO5S2
![Methyl 3-[(2,4-difluorophenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C19H15F2NO4S2, CAS 946268-70-8](/s/FQDRIQCAURJORT-UHFFFAOYSA-N.svg)
Methyl 3-[(2,4-difluorophenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 946268-70-8C19H15F2NO4S2
![Methyl 4-(4-methylphenyl)-3-{[4-(trifluoromethoxy)phenyl]sulfamoyl}thiophene-2-carboxylate chemical structure, C20H16F3NO5S2, CAS 959529-86-3](/s/XMTWSPZEDDIVPM-UHFFFAOYSA-N.svg)
Methyl 4-(4-methylphenyl)-3-{[4-(trifluoromethoxy)phenyl]sulfamoyl}thiophene-2-carboxylate
CAS 959529-86-3C20H16F3NO5S2
![Methyl 4-(4-methylphenyl)-3-[(3,4,5-trimethoxyphenyl)sulfamoyl]thiophene-2-carboxylate chemical structure, C22H23NO7S2, CAS 941888-53-5](/s/LSTJELIFHPNUHP-UHFFFAOYSA-N.svg)
Methyl 4-(4-methylphenyl)-3-[(3,4,5-trimethoxyphenyl)sulfamoyl]thiophene-2-carboxylate
CAS 941888-53-5C22H23NO7S2
![Methyl 3-[(5-chloro-2,4-dimethoxyphenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C21H20ClNO6S2, CAS 941888-55-7](/s/XHVNBGGZAUNINI-UHFFFAOYSA-N.svg)
Methyl 3-[(5-chloro-2,4-dimethoxyphenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 941888-55-7C21H20ClNO6S2
![Methyl 3-[(2-ethoxyphenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C21H21NO5S2, CAS 941888-59-1](/s/FUXIGAOAXKKOHT-UHFFFAOYSA-N.svg)
Methyl 3-[(2-ethoxyphenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 941888-59-1C21H21NO5S2
![Methyl 3-{[4-(dimethylamino)phenyl]sulfamoyl}-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C21H22N2O4S2, CAS 941978-60-5](/s/DFSDYGGKZMSUKG-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(dimethylamino)phenyl]sulfamoyl}-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 941978-60-5C21H22N2O4S2
![Ethyl 3-[(3-ethylphenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C22H23NO4S2, CAS 959553-74-3](/s/BKLBOFBZRGVAHI-UHFFFAOYSA-N.svg)
Ethyl 3-[(3-ethylphenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 959553-74-3C22H23NO4S2
![Ethyl 3-[(2,5-dimethylphenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C22H23NO4S2, CAS 946384-68-5](/s/XBSJOCNECRMVJX-UHFFFAOYSA-N.svg)
Ethyl 3-[(2,5-dimethylphenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 946384-68-5C22H23NO4S2
![Ethyl 3-[(3,4-difluorophenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C20H17F2NO4S2, CAS 946235-04-7](/s/BXGAWXCNKVZUIR-UHFFFAOYSA-N.svg)
Ethyl 3-[(3,4-difluorophenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 946235-04-7C20H17F2NO4S2
![Ethyl 3-[(3-chloro-4-methoxyphenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C21H20ClNO5S2, CAS 946322-77-6](/s/IMPCJHDDDAGSIP-UHFFFAOYSA-N.svg)
Ethyl 3-[(3-chloro-4-methoxyphenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 946322-77-6C21H20ClNO5S2
![Ethyl 3-[(2,5-dimethoxyphenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate chemical structure, C22H23NO6S2, CAS 946322-81-2](/s/SQDHEUCRJQNXLJ-UHFFFAOYSA-N.svg)
Ethyl 3-[(2,5-dimethoxyphenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate
CAS 946322-81-2C22H23NO6S2
- Ethyl 3-[(5-chloro-2-methoxyphenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate946384-84-5C21H20ClNO5S2
- Methyl 4-phenyl-3-(phenylsulfamoyl)thiophene-2-carboxylate895263-17-9C18H15NO4S2
- Methyl 3-[(3-chloro-4-methoxyphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate899977-18-5C19H16ClNO5S2
- Methyl 3-[(5-chloro-2-methoxyphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate899725-04-3C19H16ClNO5S2
- Methyl 3-[(4-chloro-2-methoxy-5-methylphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate932353-67-8C20H18ClNO5S2
- Methyl 3-[(3-chloro-4-methoxyphenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate941978-52-5C20H18ClNO5S2
- Methyl 3-[(5-chloro-2-methoxyphenyl)sulfamoyl]-4-(4-methylphenyl)thiophene-2-carboxylate941978-58-1C20H18ClNO5S2
- Methyl 3-[(4-methylphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate895263-23-7C19H17NO4S2
- Methyl 3-[(3-methylphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate895263-30-6C19H17NO4S2
- Methyl 3-[(3-ethylphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate895263-44-2C20H19NO4S2
- Methyl 3-[(3,4-dimethylphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate895263-51-1C20H19NO4S2
- Methyl 3-[(2,4-dimethylphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate895263-58-8C20H19NO4S2
- Methyl 3-[(3-fluoro-4-methylphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate895263-72-6C19H16FNO4S2
- Methyl 3-[(3,5-dimethylphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate899977-13-0C20H19NO4S2
- Methyl 3-[(2-methoxy-5-methylphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate899724-96-0C20H19NO5S2
- Methyl 3-[(4-ethoxyphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate899724-98-2C20H19NO5S2
- Methyl 3-[(4-methoxyphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate899725-00-9C19H17NO5S2
- Methyl 3-[(5-chloro-2,4-dimethoxyphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate899725-02-1C20H18ClNO6S2
- Methyl 3-[(3-methoxyphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate899965-88-9C19H17NO5S2
- Methyl 3-[(2-methoxyphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate899965-90-3C19H17NO5S2
- Methyl 3-[(2-ethoxyphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate899725-43-0C20H19NO5S2
- Ethyl 4-phenyl-3-(phenylsulfamoyl)thiophene-2-carboxylate899723-41-2C19H17NO4S2
- Ethyl 3-[(3-methylphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate900012-27-3C20H19NO4S2
- Ethyl 3-[(3,4-dimethylphenyl)sulfamoyl]-4-phenylthiophene-2-carboxylate899970-86-6C21H21NO4S2
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold S=c1[nH]nc(-c2ccccc2)n1N=Cc1ccccc1](/scaffold/DFCISOWMWAKUDC-UHFFFAOYSA-N/structure.svg)
S=c1[nH]nc(-c2ccccc2)n1N=Cc1ccccc1451 chemicals
O=C(Nc1ccccc1)c1conc1-c1ccccc149 chemicals![Scaffold S=c1[nH]nc(-c2ccccn2)n1N=Cc1ccccc1](/scaffold/GALNGBXIGPDSLA-UHFFFAOYSA-N/structure.svg)
S=c1[nH]nc(-c2ccccn2)n1N=Cc1ccccc148 chemicals
c1ccc(CSc2nnnn2-c2ccccc2)cc123 chemicals![Scaffold S=c1[nH]nc(COc2ccccc2)n1-c1ccccc1](/scaffold/CQOIKLYYYATDDP-UHFFFAOYSA-N/structure.svg)
S=c1[nH]nc(COc2ccccc2)n1-c1ccccc122 chemicals![Scaffold S=c1[nH]nc(C2CCCCC2)n1N=Cc1ccccc1](/scaffold/GVAFEYZTHREACJ-UHFFFAOYSA-N/structure.svg)
S=c1[nH]nc(C2CCCCC2)n1N=Cc1ccccc120 chemicals![Scaffold S=c1[nH]nc(CNc2ccccc2)n1-c1ccccc1](/scaffold/COGXRYNQJAHTTO-UHFFFAOYSA-N/structure.svg)
S=c1[nH]nc(CNc2ccccc2)n1-c1ccccc19 chemicals![Scaffold O=c1[nH][nH]c(-c2ccccc2)c1C=Nc1ccccc1](/scaffold/BGXXFAFONKWDRW-UHFFFAOYSA-N/structure.svg)
O=c1[nH][nH]c(-c2ccccc2)c1C=Nc1ccccc18 chemicals![Scaffold S=c1[nH]nc(-c2ccccc2)n1N=Cc1cccnc1](/scaffold/KVLBOHIKTCDLMC-UHFFFAOYSA-N/structure.svg)
S=c1[nH]nc(-c2ccccc2)n1N=Cc1cccnc18 chemicals
O=C(Nc1ccnn1-c1ccccc1)c1ccccc18 chemicals
S=C(Nc1ccccc1)N1N=CCC1c1ccccc17 chemicals
O=S(=O)(Cc1nnnn1-c1ccccc1)c1ccccc16 chemicals