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Murcko scaffold

Ring system with 3 rings and 20 atoms

271 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
271
With full pages
49
Scaffold SMILES

O=C(Nc1ccccc1)c1conc1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)c1conc1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 271 chemicals

Methyl 2-((3-(2-chlorophenyl)-5-methylisoxazol-4-yl)carbonylamino)benzoate chemical structure, C19H15ClN2O4, CAS 301680-63-7
Methyl 2-((3-(2-chlorophenyl)-5-methylisoxazol-4-yl)carbonylamino)benzoate
CAS 301680-63-7C19H15ClN2O4
N-(4-((3-(2-Chlorophenyl)-5-methylisoxazol-4-yl)carbonylamino)phenyl)ethanamide chemical structure, C19H16ClN3O3, CAS 294876-16-7
N-(4-((3-(2-Chlorophenyl)-5-methylisoxazol-4-yl)carbonylamino)phenyl)ethanamide
CAS 294876-16-7C19H16ClN3O3
3-(2-Chloro-6-fluorophenyl)-N-(3-chloro-4-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C17H10Cl2F2N2O2, CAS 312538-12-8
3-(2-Chloro-6-fluorophenyl)-N-(3-chloro-4-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxamide
CAS 312538-12-8C17H10Cl2F2N2O2
3-(2-Chlorophenyl)-N-(4-iodophenyl)-5-methyl-4-isoxazolecarboxamide chemical structure, C17H12ClIN2O2, CAS 301680-85-3
3-(2-Chlorophenyl)-N-(4-iodophenyl)-5-methyl-4-isoxazolecarboxamide
CAS 301680-85-3C17H12ClIN2O2
N-(4-Acetylphenyl)-3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C19H15ClN2O3, CAS 331847-89-3
N-(4-Acetylphenyl)-3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carboxamide
CAS 331847-89-3C19H15ClN2O3
N-(3-Acetamidophenyl)-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide chemical structure, C19H17N3O3, CAS 590399-64-7
N-(3-Acetamidophenyl)-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide
CAS 590399-64-7C19H17N3O3
N-(3-Chloro-4-methylphenyl)-5-methyl-3-phenyl-4-isoxazolecarboxamide chemical structure, C18H15ClN2O2, CAS 313069-19-1
N-(3-Chloro-4-methylphenyl)-5-methyl-3-phenyl-4-isoxazolecarboxamide
CAS 313069-19-1C18H15ClN2O2
3-(2-Chlorophenyl)-5-methyl-N-(4-methylphenyl)-1,2-oxazole-4-carboxamide chemical structure, C18H15ClN2O2, CAS 153947-73-0
3-(2-Chlorophenyl)-5-methyl-N-(4-methylphenyl)-1,2-oxazole-4-carboxamide
CAS 153947-73-0C18H15ClN2O2
N-(4-Methoxyphenyl)-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide chemical structure, C18H16N2O3, CAS 309950-34-3
N-(4-Methoxyphenyl)-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide
CAS 309950-34-3C18H16N2O3
N-(2,4-Difluorophenyl)-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide chemical structure, C17H12F2N2O2, CAS 433233-92-2
N-(2,4-Difluorophenyl)-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide
CAS 433233-92-2C17H12F2N2O2
3-(2-Chlorophenyl)-N-(3-fluoro-4-methylphenyl)-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C18H14ClFN2O2, CAS 381696-43-1
3-(2-Chlorophenyl)-N-(3-fluoro-4-methylphenyl)-5-methyl-1,2-oxazole-4-carboxamide
CAS 381696-43-1C18H14ClFN2O2
N-(2-Methoxyphenyl)-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide chemical structure, C18H16N2O3, CAS 352558-02-2
N-(2-Methoxyphenyl)-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide
CAS 352558-02-2C18H16N2O3
Methyl 2-[(5-methyl-3-phenylisoxazol-4-yl)carbonylamino]benzoate chemical structure, C19H16N2O4, CAS 540790-05-4
Methyl 2-[(5-methyl-3-phenylisoxazol-4-yl)carbonylamino]benzoate
CAS 540790-05-4C19H16N2O4
N-(4-Acetamidophenyl)-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide chemical structure, C19H17N3O3, CAS 521300-00-5
N-(4-Acetamidophenyl)-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide
CAS 521300-00-5C19H17N3O3
N,3-bis(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C17H12Cl2N2O2, CAS 304878-91-9
N,3-bis(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carboxamide
CAS 304878-91-9C17H12Cl2N2O2
3-(2-Chloro-6-fluorophenyl)-5-methyl-N-(4-methylphenyl)-1,2-oxazole-4-carboxamide chemical structure, C18H14ClFN2O2, CAS 153949-56-5
3-(2-Chloro-6-fluorophenyl)-5-methyl-N-(4-methylphenyl)-1,2-oxazole-4-carboxamide
CAS 153949-56-5C18H14ClFN2O2
3-(2-Chlorophenyl)-N-(3,4-dimethylphenyl)-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C19H17ClN2O2, CAS 331430-90-1
3-(2-Chlorophenyl)-N-(3,4-dimethylphenyl)-5-methyl-1,2-oxazole-4-carboxamide
CAS 331430-90-1C19H17ClN2O2
3-(2-Chlorophenyl)-5-methyl-N-(3-methylphenyl)-4-isoxazolecarboxamide chemical structure, C18H15ClN2O2, CAS 301680-73-9
3-(2-Chlorophenyl)-5-methyl-N-(3-methylphenyl)-4-isoxazolecarboxamide
CAS 301680-73-9C18H15ClN2O2
3-(2-Chlorophenyl)-N-(2,3-dimethylphenyl)-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C19H17ClN2O2, CAS 84896-48-0
3-(2-Chlorophenyl)-N-(2,3-dimethylphenyl)-5-methyl-1,2-oxazole-4-carboxamide
CAS 84896-48-0C19H17ClN2O2
3-(2-Chlorophenyl)-N-(2,4-dimethylphenyl)-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C19H17ClN2O2, CAS 301680-74-0
3-(2-Chlorophenyl)-N-(2,4-dimethylphenyl)-5-methyl-1,2-oxazole-4-carboxamide
CAS 301680-74-0C19H17ClN2O2
3-(2-Chlorophenyl)-N-(2,5-dimethylphenyl)-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C19H17ClN2O2, CAS 301680-75-1
3-(2-Chlorophenyl)-N-(2,5-dimethylphenyl)-5-methyl-1,2-oxazole-4-carboxamide
CAS 301680-75-1C19H17ClN2O2
3-(2-Chlorophenyl)-N-(3,5-dimethylphenyl)-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C19H17ClN2O2, CAS 301680-76-2
3-(2-Chlorophenyl)-N-(3,5-dimethylphenyl)-5-methyl-1,2-oxazole-4-carboxamide
CAS 301680-76-2C19H17ClN2O2
3-(2-Chloro-6-fluorophenyl)-N-(2-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C17H11ClF2N2O2, CAS 429627-17-8
3-(2-Chloro-6-fluorophenyl)-N-(2-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxamide
CAS 429627-17-8C17H11ClF2N2O2
3-(2-Chlorophenyl)-N-(3-chlorophenyl)-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C17H12Cl2N2O2, CAS 301227-22-5
3-(2-Chlorophenyl)-N-(3-chlorophenyl)-5-methyl-1,2-oxazole-4-carboxamide
CAS 301227-22-5C17H12Cl2N2O2