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Murcko scaffold

Ring system with 3 rings and 20 atoms

51 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
51
With full pages
48
Scaffold SMILES

S=c1[nH]nc(-c2ccccn2)n1N=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold S=c1[nH]nc(-c2ccccn2)n1N=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 51 chemicals

5(2-Pyridinyl)4-((2-(trifluoromethyl)benzylidene)amino)4H-1,2,4-triazole-3-thiol chemical structure, C15H10F3N5S, CAS 613248-27-4
5(2-Pyridinyl)4-((2-(trifluoromethyl)benzylidene)amino)4H-1,2,4-triazole-3-thiol
CAS 613248-27-4C15H10F3N5S
4-((2-Methoxybenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol chemical structure, C15H13N5OS, CAS 497823-89-9
4-((2-Methoxybenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol
CAS 497823-89-9C15H13N5OS
4-((4-Methylbenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol chemical structure, C15H13N5S, CAS 497823-85-5
4-((4-Methylbenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol
CAS 497823-85-5C15H13N5S
4-((4-Ethoxybenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol chemical structure, C16H15N5OS, CAS 613248-23-0
4-((4-Ethoxybenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol
CAS 613248-23-0C16H15N5OS
4-((3-Methylbenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol chemical structure, C15H13N5S, CAS 497824-04-1
4-((3-Methylbenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol
CAS 497824-04-1C15H13N5S
4-[(E)-(2-Methylphenyl)methylideneamino]-3-pyridin-2-yl-1H-1,2,4-triazole-5-thione chemical structure, C15H13N5S, CAS 613248-52-5
4-[(E)-(2-Methylphenyl)methylideneamino]-3-pyridin-2-yl-1H-1,2,4-triazole-5-thione
CAS 613248-52-5C15H13N5S
4-((3-Methoxybenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol chemical structure, C15H13N5OS, CAS 497823-99-1
4-((3-Methoxybenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol
CAS 497823-99-1C15H13N5OS
4-((4-Isopropylbenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol chemical structure, C17H17N5S, CAS 497823-94-6
4-((4-Isopropylbenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol
CAS 497823-94-6C17H17N5S
4-((4-Methoxybenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol chemical structure, C15H13N5OS, CAS 613248-32-1
4-((4-Methoxybenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol
CAS 613248-32-1C15H13N5OS
4-((4-tert-Butylbenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol chemical structure, C18H19N5S, CAS 613248-25-2
4-((4-tert-Butylbenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol
CAS 613248-25-2C18H19N5S
5-(2-Pyridinyl)-4-((2,4,5-trimethoxybenzylidene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C17H17N5O3S, CAS 497823-65-1
5-(2-Pyridinyl)-4-((2,4,5-trimethoxybenzylidene)amino)-4H-1,2,4-triazole-3-thiol
CAS 497823-65-1C17H17N5O3S
4-(((3-Mercapto-5-(2-pyridinyl)-4H-1,2,4-triazol-4-yl)imino)ME)-2-meo-PH acetate chemical structure, C17H15N5O3S, CAS 497823-97-9
4-(((3-Mercapto-5-(2-pyridinyl)-4H-1,2,4-triazol-4-yl)imino)ME)-2-meo-PH acetate
CAS 497823-97-9C17H15N5O3S
5-(2-Pyridinyl)-4-((2,3,4-trimethoxybenzylidene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C17H17N5O3S, CAS 497823-64-0
5-(2-Pyridinyl)-4-((2,3,4-trimethoxybenzylidene)amino)-4H-1,2,4-triazole-3-thiol
CAS 497823-64-0C17H17N5O3S
4-((2-Chlorobenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol chemical structure, C14H10ClN5S, CAS 613248-33-2
4-((2-Chlorobenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol
CAS 613248-33-2C14H10ClN5S
4-((3-BR-4-Methoxybenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol chemical structure, C15H12BrN5OS, CAS 613248-50-3
4-((3-BR-4-Methoxybenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol
CAS 613248-50-3C15H12BrN5OS
4-((2-Fluorobenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol chemical structure, C14H10FN5S, CAS 613248-16-1
4-((2-Fluorobenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol
CAS 613248-16-1C14H10FN5S
4-((4-Bromobenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl hydrosulfide chemical structure, C14H10BrN5S, CAS 497823-80-0
4-((4-Bromobenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl hydrosulfide
CAS 497823-80-0C14H10BrN5S
4-{[(E)-(3-Nitrophenyl)methylidene]amino}-5-(pyridin-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione chemical structure, C14H10N6O2S, CAS 613248-35-4
4-{[(E)-(3-Nitrophenyl)methylidene]amino}-5-(pyridin-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
CAS 613248-35-4C14H10N6O2S
4-((4-Fluorobenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol chemical structure, C14H10FN5S, CAS 497823-57-1
4-((4-Fluorobenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol
CAS 497823-57-1C14H10FN5S
4-((3-Bromobenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl hydrosulfide chemical structure, C14H10BrN5S, CAS 613248-13-8
4-((3-Bromobenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl hydrosulfide
CAS 613248-13-8C14H10BrN5S
4-((2,4-Dichlorobenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol chemical structure, C14H9Cl2N5S, CAS 497823-82-2
4-((2,4-Dichlorobenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol
CAS 497823-82-2C14H9Cl2N5S
4-((2,6-Dichlorobenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol chemical structure, C14H9Cl2N5S, CAS 613248-24-1
4-((2,6-Dichlorobenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol
CAS 613248-24-1C14H9Cl2N5S
4-((3-Fluorobenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol chemical structure, C14H10FN5S, CAS 497824-02-9
4-((3-Fluorobenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol
CAS 497824-02-9C14H10FN5S
4-((2-Chloro-5-nitrobenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol chemical structure, C14H9ClN6O2S, CAS 613248-53-6
4-((2-Chloro-5-nitrobenzylidene)amino)-5-(2-pyridinyl)-4H-1,2,4-triazole-3-thiol
CAS 613248-53-6C14H9ClN6O2S