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Murcko scaffold

Ring system with 3 rings and 20 atoms

23 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
23
With full pages
9
Scaffold SMILES

S=c1[nH]nc(CNc2ccccc2)n1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold S=c1[nH]nc(CNc2ccccc2)n1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

5-((2,6-Dimethylanilino)methyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione chemical structure, C17H18N4S, CAS 493003-34-2
5-((2,6-Dimethylanilino)methyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione
CAS 493003-34-2C17H18N4S
3-[(2,4-Dimethylanilino)methyl]-4-phenyl-1H-1,2,4-triazole-5-thione chemical structure, C17H18N4S, CAS 494195-73-2
3-[(2,4-Dimethylanilino)methyl]-4-phenyl-1H-1,2,4-triazole-5-thione
CAS 494195-73-2C17H18N4S
5-(((2-Methyl-5-nitrophenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazole-3-thiol chemical structure, C16H15N5O2S, CAS 493013-77-7
5-(((2-Methyl-5-nitrophenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazole-3-thiol
CAS 493013-77-7C16H15N5O2S
5-(((3-Chloro-4-methylphenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazole-3-thiol chemical structure, C16H15ClN4S, CAS 494193-65-6
5-(((3-Chloro-4-methylphenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazole-3-thiol
CAS 494193-65-6C16H15ClN4S
5-((4-Fluoroanilino)methyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione chemical structure, C15H13FN4S, CAS 482645-52-3
5-((4-Fluoroanilino)methyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione
CAS 482645-52-3C15H13FN4S
4-Phenyl-5-(3-toluidinomethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione chemical structure, C16H16N4S, CAS 436088-98-1
4-Phenyl-5-(3-toluidinomethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
CAS 436088-98-1C16H16N4S
5-((3-Chloroanilino)methyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione chemical structure, C15H13ClN4S, CAS 482638-09-5
5-((3-Chloroanilino)methyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione
CAS 482638-09-5C15H13ClN4S
5-[(4-Iodoanilino)methyl]-4-phenyl-4H-1,2,4-triazole-3-thiol chemical structure, C15H13IN4S, CAS 362609-49-2
5-[(4-Iodoanilino)methyl]-4-phenyl-4H-1,2,4-triazole-3-thiol
CAS 362609-49-2C15H13IN4S
5-((4-Methoxyanilino)methyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione chemical structure, C16H16N4OS, CAS 92516-07-9
5-((4-Methoxyanilino)methyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione
CAS 92516-07-9C16H16N4OS
5-((3-CL-2-Methylanilino)methyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione chemical structure, C16H15ClN4S, CAS 539811-30-8
5-((3-CL-2-Methylanilino)methyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione
CAS 539811-30-8C16H15ClN4S
5-((3,4-Dichloroanilino)methyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione chemical structure, C15H12Cl2N4S, CAS 539811-22-8
5-((3,4-Dichloroanilino)methyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione
CAS 539811-22-8C15H12Cl2N4S
5-{[(4-Chlorophenyl)amino]methyl}-4-phenyl-4H-1,2,4-triazole-3-thiol chemical structure, C15H13ClN4S, CAS 92516-08-0
5-{[(4-Chlorophenyl)amino]methyl}-4-phenyl-4H-1,2,4-triazole-3-thiol
CAS 92516-08-0C15H13ClN4S
5-(((4-Ethoxyphenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazole-3-thiol chemical structure, C17H18N4OS, CAS 917750-40-4
5-(((4-Ethoxyphenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazole-3-thiol
CAS 917750-40-4C17H18N4OS
4-(2,3-Dimethylphenyl)-5-((p-tolylamino)methyl)-4H-1,2,4-triazole-3-thiol chemical structure, C18H20N4S, CAS 914207-02-6
4-(2,3-Dimethylphenyl)-5-((p-tolylamino)methyl)-4H-1,2,4-triazole-3-thiol
CAS 914207-02-6C18H20N4S
4-(3-Methoxyphenyl)-5-((p-tolylamino)methyl)-4H-1,2,4-triazole-3-thiol chemical structure, C17H18N4OS, CAS 917749-63-4
4-(3-Methoxyphenyl)-5-((p-tolylamino)methyl)-4H-1,2,4-triazole-3-thiol
CAS 917749-63-4C17H18N4OS
4-(3,5-Dimethoxyphenyl)-5-(((4-fluorophenyl)amino)methyl)-4H-1,2,4-triazole-3-thiol chemical structure, C17H17FN4O2S, CAS 917750-08-4
4-(3,5-Dimethoxyphenyl)-5-(((4-fluorophenyl)amino)methyl)-4H-1,2,4-triazole-3-thiol
CAS 917750-08-4C17H17FN4O2S
4-(4-Ethylphenyl)-5-(((4-fluorophenyl)amino)methyl)-4H-1,2,4-triazole-3-thiol chemical structure, C17H17FN4S, CAS 917750-12-0
4-(4-Ethylphenyl)-5-(((4-fluorophenyl)amino)methyl)-4H-1,2,4-triazole-3-thiol
CAS 917750-12-0C17H17FN4S
5-(((4-Fluorophenyl)amino)methyl)-4-(m-tolyl)-4H-1,2,4-triazole-3-thiol chemical structure, C16H15FN4S, CAS 917750-15-3
5-(((4-Fluorophenyl)amino)methyl)-4-(m-tolyl)-4H-1,2,4-triazole-3-thiol
CAS 917750-15-3C16H15FN4S
4-(2-Ethoxyphenyl)-5-(((4-fluorophenyl)amino)methyl)-4H-1,2,4-triazole-3-thiol chemical structure, C17H17FN4OS, CAS 917750-16-4
4-(2-Ethoxyphenyl)-5-(((4-fluorophenyl)amino)methyl)-4H-1,2,4-triazole-3-thiol
CAS 917750-16-4C17H17FN4OS
5-(((4-Fluorophenyl)amino)methyl)-4-(2-methoxyphenyl)-4H-1,2,4-triazole-3-thiol chemical structure, C16H15FN4OS, CAS 917750-19-7
5-(((4-Fluorophenyl)amino)methyl)-4-(2-methoxyphenyl)-4H-1,2,4-triazole-3-thiol
CAS 917750-19-7C16H15FN4OS
4-(2,5-Dimethylphenyl)-5-(((4-fluorophenyl)amino)methyl)-4H-1,2,4-triazole-3-thiol chemical structure, C17H17FN4S, CAS 917750-23-3
4-(2,5-Dimethylphenyl)-5-(((4-fluorophenyl)amino)methyl)-4H-1,2,4-triazole-3-thiol
CAS 917750-23-3C17H17FN4S
4-(2-Methylphenyl)-5-[(phenylamino)methyl]-4H-1,2,4-triazole-3-thiol chemical structure, C16H16N4S, CAS 914206-36-3
4-(2-Methylphenyl)-5-[(phenylamino)methyl]-4H-1,2,4-triazole-3-thiol
CAS 914206-36-3C16H16N4S
4-(3-Methoxyphenyl)-5-[(phenylamino)methyl]-4H-1,2,4-triazole-3-thiol chemical structure, C16H16N4OS, CAS 914207-00-4
4-(3-Methoxyphenyl)-5-[(phenylamino)methyl]-4H-1,2,4-triazole-3-thiol
CAS 914207-00-4C16H16N4OS