Murcko scaffold
Ring system with 2 rings and 13 atoms
58 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 13
- Chemicals
- 58
- With full pages
- 3
Scaffold SMILES
c1ccc(OCc2ccno2)cc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 58 chemicals
Of 4452
CAS 85089-67-4C17H23ClN2O4
![5-[(3,5-Dichlorophenoxy)methyl]-3-isoxazolecarboxylic acid 2-(1-oxopropyl)hydrazide chemical structure, C14H13Cl2N3O4, CAS 685541-35-9](/s/BAYMIIBFQAXUOM-UHFFFAOYSA-N.svg)
5-[(3,5-Dichlorophenoxy)methyl]-3-isoxazolecarboxylic acid 2-(1-oxopropyl)hydrazide
CAS 685541-35-9C14H13Cl2N3O4
2-Propanol, 3-(isopropylamino)-1-(o-((3-methyl-5-isoxazolyl)methoxy)phenoxy)-, hydrochloride
CAS 90288-65-6C17H25ClN2O4
2-Propanol, 1-(o-((4-chloro-3-methyl-5-isoxazolyl)methoxy)phenoxy)-3-(isopropylamino)-, hydrochloride
CAS 90288-66-7C17H24Cl2N2O4
![Phenol, 2-[(4-bromo-3-methyl-5-isoxazolyl)methoxy]- chemical structure, C11H10BrNO3, CAS 90288-55-4](/s/RYJQJSYXFRDXDP-UHFFFAOYSA-N.svg)
Phenol, 2-[(4-bromo-3-methyl-5-isoxazolyl)methoxy]-
CAS 90288-55-4C11H10BrNO3
RefChem:382202
CAS 90288-54-3C11H10ClNO3
![5-[1-(4-Chlorophenoxy)ethyl]-1,2-oxazole chemical structure, C11H10ClNO2, CAS 338976-10-6](/s/AICCMGAVPYXTMO-UHFFFAOYSA-N.svg)
5-[1-(4-Chlorophenoxy)ethyl]-1,2-oxazole
CAS 338976-10-6C11H10ClNO2
![5-[1-(2,4-Dichlorophenoxy)ethyl]-1,2-oxazole chemical structure, C11H9Cl2NO2, CAS 338976-11-7](/s/BDIZKBDMTMCXLD-UHFFFAOYSA-N.svg)
5-[1-(2,4-Dichlorophenoxy)ethyl]-1,2-oxazole
CAS 338976-11-7C11H9Cl2NO2
5-(1-Phenoxyethyl)-1,2-oxazole
CAS 338976-12-8C11H11NO2
![5-{1-[3-(Trifluoromethyl)phenoxy]ethyl}isoxazole chemical structure, C12H10F3NO2, CAS 338976-13-9](/s/AAVVHUKYGGKRSQ-UHFFFAOYSA-N.svg)
5-{1-[3-(Trifluoromethyl)phenoxy]ethyl}isoxazole
CAS 338976-13-9C12H10F3NO2
Methyl 4-(isoxazol-5-ylmethoxy)benzoate
CAS 890091-84-6C12H11NO4
2-Propanol, 1-(o-((4-bromo-3-methyl-5-isoxazolyl)methoxy)phenoxy)-3-(isopropylamino)-, hydrochloride
CAS 90288-67-8C17H24BrClN2O4
2-Propanol, 1-(2-((4-chloro-3-methyl-5-isoxazolyl)methoxy)phenoxy)-3-((1-methylpropyl)amino)-, monohydrochloride
CAS 90288-72-5C18H26Cl2N2O4
2-Propanol, 3-(tert-butylamino)-1-(o-((4-chloro-3-methyl-5-isoxazolyl)methoxy)phenoxy)-, hydrochloride
CAS 90288-71-4C18H26Cl2N2O4
![3-Methyl-5-[(2-methylphenoxy)methyl]-4-isoxazolecarboxylic acid chemical structure, C13H13NO4, CAS 106967-81-1](/s/UYZNIENWVDTUOD-UHFFFAOYSA-N.svg)
3-Methyl-5-[(2-methylphenoxy)methyl]-4-isoxazolecarboxylic acid
CAS 106967-81-1C13H13NO4
![5-[(4-Fluorophenoxy)methyl]isoxazole-3-carboxylic acid chemical structure, C11H8FNO4, CAS 932917-26-5](/s/CDPLOXPSTMVOIU-UHFFFAOYSA-N.svg)
5-[(4-Fluorophenoxy)methyl]isoxazole-3-carboxylic acid
CAS 932917-26-5C11H8FNO4
![5-[(2-Fluorophenoxy)methyl]isoxazole-3-carboxylic acid chemical structure, C11H8FNO4, CAS 932780-62-6](/s/DBBAKPJCJRFCHW-UHFFFAOYSA-N.svg)
5-[(2-Fluorophenoxy)methyl]isoxazole-3-carboxylic acid
CAS 932780-62-6C11H8FNO4
3-Methoxy-4-((3-methylisoxazol-5-yl)methoxy)benzonitrile
CAS 1042799-24-5C13H12N2O3
5-Chloro-2-(3-methylisoxazol-5-ylmethoxy)benzylamine
CAS 331729-40-9C12H13ClN2O2
5-(Phenoxymethyl)-1,2-oxazole-3-carboxylic acid
CAS 932801-86-0C11H9NO4
![5-[(3-Methylphenoxy)methyl]-1,2-oxazole-3-carboxylic acid chemical structure, C12H11NO4, CAS 932848-50-5](/s/YUAVIHGJSYNVHJ-UHFFFAOYSA-N.svg)
5-[(3-Methylphenoxy)methyl]-1,2-oxazole-3-carboxylic acid
CAS 932848-50-5C12H11NO4
Methyl 5-(2-fluorophenoxymethyl)-1,2-oxazole-3-carboxylate
CAS 932780-86-4C12H10FNO4
5-((2,4-Difluorophenoxy)methyl)-1,2-oxazole-3-carboxylic acid
CAS 932917-90-3C11H7F2NO4
![5-[(2-Ethoxyphenoxy)methyl]-3-isoxazolecarboxylic acid chemical structure, C13H13NO5, CAS 932894-22-9](/s/PSQWGYQLDFVUNW-UHFFFAOYSA-N.svg)
5-[(2-Ethoxyphenoxy)methyl]-3-isoxazolecarboxylic acid
CAS 932894-22-9C13H13NO5
- 5-[(4-tert-Butylphenoxy)methyl]-1,2-oxazole-3-carboxylic acid932830-54-1C15H17NO4
- 5-(2,4-Dichlorophenoxymethyl)-1,2-oxazole-3-carboxylic acid932894-91-2C11H7Cl2NO4
- Methyl 5-((2,4-dichlorophenoxy)methyl)isoxazole-3-carboxylate932782-41-7C12H9Cl2NO4
- 4-((3-Methylisoxazol-5-yl)methoxy)benzoic acid1042778-05-1C12H11NO4
- 3-{3-Ethoxy-2-[(1,2-oxazol-5-yl)methoxy]phenyl}prop-2-enoic acid1099617-92-1C15H15NO5
- 3-Bromo-4-[(3-methyl-1,2-oxazol-5-yl)methoxy]benzoic acid1221724-03-3C12H10BrNO4
- 1-(5-Chloro-2-((3-methylisoxazol-5-yl)methoxy)phenyl)ethan-1-one1311824-93-7C13H12ClNO3
- N-Ethyl-2-(5-isoxazolylmethoxy)-5-nitrobenzenemethanamine1184740-10-0C13H15N3O4
- 3-Ethoxy-4-(5-isoxazolylmethoxy)-I+/--methylbenzeneethanamine1183836-68-1C15H20N2O3
- 5-(3-Acetylphenoxymethyl)-1,2-oxazole-3-carboxylic acid1281554-27-5C13H11NO5
- 5-((3-Fluorophenoxy)methyl)isoxazole-3-carboxylic acid1226003-13-9C11H8FNO4
- 5-((2,6-Dichlorophenoxy)methyl)-1,2-oxazole-3-carboxylic acid1225900-23-1C11H7Cl2NO4
- 5-(3-Trifluoromethylphenoxymethyl)isoxazole-3-carboxylic acid1305288-95-2C12H8F3NO4
- [5-(2-Fluorophenoxymethyl)-1,2-oxazol-3-yl]methanamine1249836-90-5C11H11FN2O2
- N-(Cyanomethyl)-5-[(2,6-dichlorophenoxy)methyl]-1,2-oxazole-3-carboxamide1427727-04-5C13H9Cl2N3O3
- N-(Cyanomethyl)-5-[(2,6-dichlorophenoxy)methyl]-N-methyl-1,2-oxazole-3-carboxamide1424305-15-6C14H11Cl2N3O3
- [5-(2-Fluorophenoxymethyl)-1,2-oxazol-3-yl]methanol1803609-62-2C11H10FNO3
- 3-(Chloromethyl)-5-[(2-fluorophenoxy)methyl]-1,2-oxazole1803593-77-2C11H9ClFNO2
- 3-Bromo-5-(phenoxymethyl)isoxazole1447949-49-6C10H8BrNO2
- 3-Bromo-5-((3-fluorophenoxy)methyl)isoxazole1447962-16-4C10H7BrFNO2
- 3-Bromo-5-((4-fluorophenoxy)methyl)isoxazole1447949-63-4C10H7BrFNO2
- 3-Bromo-5-((2-chlorophenoxy)methyl)isoxazole1447961-78-5C10H7BrClNO2
- 3-Bromo-5-((4-chlorophenoxy)methyl)isoxazole1447962-25-5C10H7BrClNO2
- 3-Bromo-5-((3-methoxyphenoxy)methyl)isoxazole1447958-28-2C11H10BrNO3
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(Nc1ccccc1)c1ccco1208 chemicals
O=C(Nc1ccccc1)c1cccs1150 chemicals
O=C(Nc1nccs1)c1ccccc1121 chemicals![Scaffold O=C(N=c1[nH]ncs1)c1ccccc1](/scaffold/RWOUBULBQYRRNL-UHFFFAOYSA-N/structure.svg)
O=C(N=c1[nH]ncs1)c1ccccc187 chemicals
c1ccc(OCc2ccco2)cc175 chemicals
O=S(=O)(Nc1nccs1)c1ccccc161 chemicals![Scaffold c1ccc(CSc2ncn[nH]2)cc1](/scaffold/IQQYSQRJFHUASD-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2ncn[nH]2)cc160 chemicals![Scaffold O=C(Nc1ccccc1)c1cc[nH]n1](/scaffold/WMZYZYFPPQOFKY-UHFFFAOYSA-N/structure.svg)
O=C(Nc1ccccc1)c1cc[nH]n160 chemicals
O=C(Nc1cccs1)c1ccccc152 chemicals
O=C(Nc1ccccc1)C1CCCO150 chemicals
O=C(Nc1ccccc1)c1ccoc148 chemicals
c1ccc(CSc2nncs2)cc144 chemicals