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Murcko scaffold

Ring system with 3 rings and 16 atoms

12 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
12
With full pages
3
Scaffold SMILES

O=C1C2C=NOC2C(=O)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C2C=NOC2C(=O)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

3-Acetyl-5-(4-chlorophenyl)-3aH-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione chemical structure, C13H9ClN2O4, CAS 454473-68-8
3-Acetyl-5-(4-chlorophenyl)-3aH-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione
CAS 454473-68-8C13H9ClN2O4
Methyl 5-(4-chlorophenyl)-4,6-dioxo-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-3-carboxylate chemical structure, C13H9ClN2O5, CAS 339110-65-5
Methyl 5-(4-chlorophenyl)-4,6-dioxo-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-3-carboxylate
CAS 339110-65-5C13H9ClN2O5
Methyl 5-(4-fluorophenyl)-4,6-dioxo-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-3-carboxylate chemical structure, C13H9FN2O5, CAS 675842-57-6
Methyl 5-(4-fluorophenyl)-4,6-dioxo-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-3-carboxylate
CAS 675842-57-6C13H9FN2O5
Methyl 5-(4-methoxyphenyl)-4,6-dioxo-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-3-carboxylate chemical structure, C14H12N2O6, CAS 675844-86-7
Methyl 5-(4-methoxyphenyl)-4,6-dioxo-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-3-carboxylate
CAS 675844-86-7C14H12N2O6
Ethyl 5-(4-chlorophenyl)-4,6-dioxo-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-3-carboxylate chemical structure, C14H11ClN2O5, CAS 338792-98-6
Ethyl 5-(4-chlorophenyl)-4,6-dioxo-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-3-carboxylate
CAS 338792-98-6C14H11ClN2O5
Ethyl 5-(4-fluorophenyl)-4,6-dioxo-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-3-carboxylate chemical structure, C14H11FN2O5, CAS 676442-51-6
Ethyl 5-(4-fluorophenyl)-4,6-dioxo-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-3-carboxylate
CAS 676442-51-6C14H11FN2O5
Ethyl 5-(4-methoxyphenyl)-4,6-dioxo-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-3-carboxylate chemical structure, C15H14N2O6, CAS 677024-11-2
Ethyl 5-(4-methoxyphenyl)-4,6-dioxo-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-3-carboxylate
CAS 677024-11-2C15H14N2O6
3-Acetyl-5-phenyl-3aH-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione chemical structure, C13H10N2O4, CAS 338795-02-1
3-Acetyl-5-phenyl-3aH-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione
CAS 338795-02-1C13H10N2O4
3-Acetyl-5-[3-(trifluoromethyl)phenyl]-3aH-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione chemical structure, C14H9F3N2O4, CAS 339276-46-9
3-Acetyl-5-[3-(trifluoromethyl)phenyl]-3aH-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione
CAS 339276-46-9C14H9F3N2O4
Ethyl 4,6-dioxo-5-[3-(trifluoromethyl)phenyl]-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-3-carboxylate chemical structure, C15H11F3N2O5, CAS 338422-50-7
Ethyl 4,6-dioxo-5-[3-(trifluoromethyl)phenyl]-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-3-carboxylate
CAS 338422-50-7C15H11F3N2O5
Ethyl 5-(2,4-dichlorophenyl)-4,6-dioxo-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-3-carboxylate chemical structure, C14H10Cl2N2O5, CAS 339011-65-3
Ethyl 5-(2,4-dichlorophenyl)-4,6-dioxo-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-3-carboxylate
CAS 339011-65-3C14H10Cl2N2O5
Methyl 5-(4-bromophenyl)-4,6-dioxo-3a,6a-dihydropyrrolo[3,4-d][1,2]oxazole-3-carboxylate chemical structure, C13H9BrN2O5, CAS 675188-75-7
Methyl 5-(4-bromophenyl)-4,6-dioxo-3a,6a-dihydropyrrolo[3,4-d][1,2]oxazole-3-carboxylate
CAS 675188-75-7C13H9BrN2O5