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Murcko scaffold

Ring system with 2 rings and 12 atoms

151 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
151
With full pages
9
Scaffold SMILES

O=c1[nH]cnn1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1[nH]cnn1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 151 chemicals

2,5-Dihydro-1-(4-nitrophenyl)-5-oxo-1H-1,2,4-triazole-3-carboxylic acid chemical structure, C9H6N4O5, CAS 854738-30-0
2,5-Dihydro-1-(4-nitrophenyl)-5-oxo-1H-1,2,4-triazole-3-carboxylic acid
CAS 854738-30-0C9H6N4O5
Methyl 2,5-dihydro-1-(4-nitrophenyl)-5-oxo-1H-1,2,4-triazole-3-carboxylate chemical structure, C10H8N4O5, CAS 412314-66-0
Methyl 2,5-dihydro-1-(4-nitrophenyl)-5-oxo-1H-1,2,4-triazole-3-carboxylate
CAS 412314-66-0C10H8N4O5
Ethyl 1-(4-nitrophenyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate chemical structure, C11H10N4O5, CAS 959314-36-4
Ethyl 1-(4-nitrophenyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate
CAS 959314-36-4C11H10N4O5
2-(2-Fluorophenyl)-1,2-dihydro-5-methyl-3H-1,2,4-triazol-3-one chemical structure, C9H8FN3O, CAS 153833-78-4
2-(2-Fluorophenyl)-1,2-dihydro-5-methyl-3H-1,2,4-triazol-3-one
CAS 153833-78-4C9H8FN3O
2-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one chemical structure, C10H6Cl2F3N3O, CAS 338401-54-0
2-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one
CAS 338401-54-0C10H6Cl2F3N3O
1-(4-Chloro-2-fluorophenyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazole chemical structure, C9H7ClFN3O, CAS 111992-04-2
1-(4-Chloro-2-fluorophenyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazole
CAS 111992-04-2C9H7ClFN3O
2-(4-Trifluoromethylphenyl)-3(2H,4H)-1,2,4-triazolone chemical structure, C9H6F3N3O, CAS 155431-32-6
2-(4-Trifluoromethylphenyl)-3(2H,4H)-1,2,4-triazolone
CAS 155431-32-6C9H6F3N3O
3H-1,2,4-Triazol-3-one, 5-butyl-2-(2-chlorophenyl)-2,4-dihydro- chemical structure, C12H14ClN3O, CAS 133690-83-2
3H-1,2,4-Triazol-3-one, 5-butyl-2-(2-chlorophenyl)-2,4-dihydro-
CAS 133690-83-2C12H14ClN3O
3-Methyl-1-phenyl-4,5-dihydro-1H-1,2,4-triazol-5-one chemical structure, C9H9N3O, CAS 22863-24-7
3-Methyl-1-phenyl-4,5-dihydro-1H-1,2,4-triazol-5-one
CAS 22863-24-7C9H9N3O
2-(2-Chloro-5-nitrophenyl)-5-methyl-1,2-dihydro-3H-1,2,4-triazol-3-one chemical structure, C9H7ClN4O3, CAS 114499-57-9
2-(2-Chloro-5-nitrophenyl)-5-methyl-1,2-dihydro-3H-1,2,4-triazol-3-one
CAS 114499-57-9C9H7ClN4O3
2-(2-Chlorophenyl)-5-methyl-1,2-dihydro-3H-1,2,4-triazol-3-one chemical structure, C9H8ClN3O, CAS 109913-40-8
2-(2-Chlorophenyl)-5-methyl-1,2-dihydro-3H-1,2,4-triazol-3-one
CAS 109913-40-8C9H8ClN3O
3H-1,2,4-Triazol-3-one, 2-(4-chlorophenyl)-2,4-dihydro- chemical structure, C8H6ClN3O, CAS 121117-98-4
3H-1,2,4-Triazol-3-one, 2-(4-chlorophenyl)-2,4-dihydro-
CAS 121117-98-4C8H6ClN3O
5-Pentyl-2-phenyl-1,2-dihydro-3H-1,2,4-triazol-3-one chemical structure, C13H17N3O, CAS 28669-30-9
5-Pentyl-2-phenyl-1,2-dihydro-3H-1,2,4-triazol-3-one
CAS 28669-30-9C13H17N3O
2-Phenyl-5-(propan-2-yl)-1,2-dihydro-3H-1,2,4-triazol-3-one chemical structure, C11H13N3O, CAS 28669-32-1
2-Phenyl-5-(propan-2-yl)-1,2-dihydro-3H-1,2,4-triazol-3-one
CAS 28669-32-1C11H13N3O
5-(Pentan-3-yl)-2-phenyl-1,2-dihydro-3H-1,2,4-triazol-3-one chemical structure, C13H17N3O, CAS 5507-95-9
5-(Pentan-3-yl)-2-phenyl-1,2-dihydro-3H-1,2,4-triazol-3-one
CAS 5507-95-9C13H17N3O
5-Methyl-2-(3-nitrophenyl)-1,2-dihydro-3H-1,2,4-triazol-3-one chemical structure, C9H8N4O3, CAS 97538-37-9
5-Methyl-2-(3-nitrophenyl)-1,2-dihydro-3H-1,2,4-triazol-3-one
CAS 97538-37-9C9H8N4O3
Ethyl 5-oxo-1-phenyl-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate chemical structure, C11H11N3O3, CAS 67267-08-7
Ethyl 5-oxo-1-phenyl-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate
CAS 67267-08-7C11H11N3O3
Isopropyl 1-(4-bromophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate chemical structure, C12H12BrN3O3, CAS 1233509-89-1
Isopropyl 1-(4-bromophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate
CAS 1233509-89-1C12H12BrN3O3
1,2,4-Triazolidine-3,5-dione, 1-phenyl-, ion(1-) chemical structure, C8H6N3O2-, CAS 135257-88-4
1,2,4-Triazolidine-3,5-dione, 1-phenyl-, ion(1-)
CAS 135257-88-4C8H6N3O2-
1-(2,4-Dichlorophenyl)-1H-1,2,4-triazol-5-one chemical structure, C8H5Cl2N3O, CAS 79604-43-6
1-(2,4-Dichlorophenyl)-1H-1,2,4-triazol-5-one
CAS 79604-43-6C8H5Cl2N3O
2-(2-Chlorophenyl)-1,2-dihydro-3H-1,2,4-triazol-3-one chemical structure, C8H6ClN3O, CAS 212202-69-2
2-(2-Chlorophenyl)-1,2-dihydro-3H-1,2,4-triazol-3-one
CAS 212202-69-2C8H6ClN3O
2-Phenyl-5-(trifluoromethyl)-1,2-dihydro-3H-1,2,4-triazol-3-one chemical structure, C9H6F3N3O, CAS 89522-08-7
2-Phenyl-5-(trifluoromethyl)-1,2-dihydro-3H-1,2,4-triazol-3-one
CAS 89522-08-7C9H6F3N3O
2-(4-Bromophenyl)-1,2-dihydro-3H-1,2,4-triazol-3-one chemical structure, C8H6BrN3O, CAS 197074-69-4
2-(4-Bromophenyl)-1,2-dihydro-3H-1,2,4-triazol-3-one
CAS 197074-69-4C8H6BrN3O
2-(3-Chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-one chemical structure, C9H8ClN3O, CAS 335064-87-4
2-(3-Chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-one
CAS 335064-87-4C9H8ClN3O