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Murcko scaffold

Ring system with 2 rings and 12 atoms

151 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
151
With full pages
9
Scaffold SMILES

O=c1[nH]cnn1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1[nH]cnn1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 97 to 144 of 151 chemicals

Methyl 1-(4-bromophenyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate chemical structure, C10H8BrN3O3, CAS 1000573-63-6
Methyl 1-(4-bromophenyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate
CAS 1000573-63-6C10H8BrN3O3
Ethyl 1-(4-fluorophenyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate chemical structure, C11H10FN3O3, CAS 1000573-68-1
Ethyl 1-(4-fluorophenyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate
CAS 1000573-68-1C11H10FN3O3
Ethyl 5-oxo-1-(o-tolyl)-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate chemical structure, C12H13N3O3, CAS 1000573-73-8
Ethyl 5-oxo-1-(o-tolyl)-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate
CAS 1000573-73-8C12H13N3O3
Ethyl 2,5-dihydro-5-oxo-1-(4-sulfamoylphenyl)-1H-1,2,4-triazole-3-carboxylate chemical structure, C11H12N4O5S, CAS 1000573-78-3
Ethyl 2,5-dihydro-5-oxo-1-(4-sulfamoylphenyl)-1H-1,2,4-triazole-3-carboxylate
CAS 1000573-78-3C11H12N4O5S
N,N-Dimethyl-1-(4-nitrophenyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazole-3-carboxamide chemical structure, C11H11N5O4, CAS 1000574-00-4
N,N-Dimethyl-1-(4-nitrophenyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazole-3-carboxamide
CAS 1000574-00-4C11H11N5O4
N,N-Dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-1,2,4-triazole-3-carboxamide chemical structure, C11H12N4O2, CAS 1000574-06-0
N,N-Dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-1,2,4-triazole-3-carboxamide
CAS 1000574-06-0C11H12N4O2
N,N-Dimethyl-1-(2-nitrophenyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazole-3-carboxamide chemical structure, C11H11N5O4, CAS 1000574-24-2
N,N-Dimethyl-1-(2-nitrophenyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazole-3-carboxamide
CAS 1000574-24-2C11H11N5O4
Isopropyl 1-(4-chlorophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate chemical structure, C12H12ClN3O3, CAS 1000574-54-8
Isopropyl 1-(4-chlorophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate
CAS 1000574-54-8C12H12ClN3O3
Isopropyl 1-(3,4-dichlorophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate chemical structure, C12H11Cl2N3O3, CAS 1000574-60-6
Isopropyl 1-(3,4-dichlorophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate
CAS 1000574-60-6C12H11Cl2N3O3
Isopropyl 5-oxo-1-(m-tolyl)-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate chemical structure, C13H15N3O3, CAS 1000574-70-8
Isopropyl 5-oxo-1-(m-tolyl)-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate
CAS 1000574-70-8C13H15N3O3
tert-Butyl 5-oxo-1-(p-tolyl)-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate chemical structure, C14H17N3O3, CAS 1000574-75-3
tert-Butyl 5-oxo-1-(p-tolyl)-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate
CAS 1000574-75-3C14H17N3O3
5-Acetyl-1,2-dihydro-2-(4-methyl-3-nitrophenyl)-3H-1,2,4-triazol-3-one chemical structure, C11H10N4O4, CAS 1000574-85-5
5-Acetyl-1,2-dihydro-2-(4-methyl-3-nitrophenyl)-3H-1,2,4-triazol-3-one
CAS 1000574-85-5C11H10N4O4
Isopropyl 1-(3,5-dichlorophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate chemical structure, C12H11Cl2N3O3, CAS 1000574-91-3
Isopropyl 1-(3,5-dichlorophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate
CAS 1000574-91-3C12H11Cl2N3O3
Ethyl 1-(2,4,6-trichlorophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate chemical structure, C11H8Cl3N3O3, CAS 1000575-03-0
Ethyl 1-(2,4,6-trichlorophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate
CAS 1000575-03-0C11H8Cl3N3O3
Methyl 1-(2,4,6-trichlorophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate chemical structure, C10H6Cl3N3O3, CAS 1000575-09-6
Methyl 1-(2,4,6-trichlorophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate
CAS 1000575-09-6C10H6Cl3N3O3
2,5-Dihydro-1-(2-nitrophenyl)-5-oxo-1H-1,2,4-triazole-3-carboxylic acid chemical structure, C9H6N4O5, CAS 1000575-42-7
2,5-Dihydro-1-(2-nitrophenyl)-5-oxo-1H-1,2,4-triazole-3-carboxylic acid
CAS 1000575-42-7C9H6N4O5
2,5-Dihydro-1-(4-nitrophenyl)-5-oxo-1H-1,2,4-triazole-3-carboxylic acid hydrazide chemical structure, C9H8N6O4, CAS 1000575-47-2
2,5-Dihydro-1-(4-nitrophenyl)-5-oxo-1H-1,2,4-triazole-3-carboxylic acid hydrazide
CAS 1000575-47-2C9H8N6O4
5-Acetyl-2-(m-tolyl)-1H-1,2,4-triazol-3(2H)-one chemical structure, C11H11N3O2, CAS 1000575-52-9
5-Acetyl-2-(m-tolyl)-1H-1,2,4-triazol-3(2H)-one
CAS 1000575-52-9C11H11N3O2
Ethyl 1-(3,5-dichlorophenyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate chemical structure, C11H9Cl2N3O3, CAS 1000576-61-3
Ethyl 1-(3,5-dichlorophenyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate
CAS 1000576-61-3C11H9Cl2N3O3
Ethyl 1-[4-chloro-2-(trifluoromethyl)phenyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate chemical structure, C12H9ClF3N3O3, CAS 1000576-73-7
Ethyl 1-[4-chloro-2-(trifluoromethyl)phenyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate
CAS 1000576-73-7C12H9ClF3N3O3
Ethyl 1-(3,4-dichlorophenyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate chemical structure, C11H9Cl2N3O3, CAS 1000576-77-1
Ethyl 1-(3,4-dichlorophenyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate
CAS 1000576-77-1C11H9Cl2N3O3
Methyl 1-(3,4-dichlorophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate chemical structure, C10H7Cl2N3O3, CAS 1000576-81-7
Methyl 1-(3,4-dichlorophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate
CAS 1000576-81-7C10H7Cl2N3O3
Methyl 1-(2-chlorophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate chemical structure, C10H8ClN3O3, CAS 1000576-85-1
Methyl 1-(2-chlorophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate
CAS 1000576-85-1C10H8ClN3O3
Ethyl 1-(3-chloro-4-fluorophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate chemical structure, C11H9ClFN3O3, CAS 1000576-89-5
Ethyl 1-(3-chloro-4-fluorophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate
CAS 1000576-89-5C11H9ClFN3O3