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Murcko scaffold

Ring system with 4 rings and 21 atoms

317 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
21
Chemicals
317
With full pages
8
Scaffold SMILES

O=C1NC(c2ccccc2)c2c1oc1ccccc1c2=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1NC(c2ccccc2)c2c1oc1ccccc1c2=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 317 chemicals

2-(2-(Dimethylamino)ethyl)-1-(4-fluorophenyl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione chemical structure, C21H19FN2O3, CAS 631866-24-5
2-(2-(Dimethylamino)ethyl)-1-(4-fluorophenyl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione
CAS 631866-24-5C21H19FN2O3
1-(2,5-Dimethoxyphenyl)-2-(3-(dimethylamino)propyl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione chemical structure, C24H26N2O5, CAS 847376-77-6
1-(2,5-Dimethoxyphenyl)-2-(3-(dimethylamino)propyl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione
CAS 847376-77-6C24H26N2O5
2-(2-(Diethylamino)ethyl)-1-(p-tolyl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione chemical structure, C24H26N2O3, CAS 631864-97-6
2-(2-(Diethylamino)ethyl)-1-(p-tolyl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione
CAS 631864-97-6C24H26N2O3
1-(2,3-Dimethoxyphenyl)-2-(3-(dimethylamino)propyl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione chemical structure, C24H26N2O5, CAS 847917-40-2
1-(2,3-Dimethoxyphenyl)-2-(3-(dimethylamino)propyl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione
CAS 847917-40-2C24H26N2O5
1-(3-Fluorophenyl)-2-(3-hydroxypropyl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione chemical structure, C20H16FNO4, CAS 850228-73-8
1-(3-Fluorophenyl)-2-(3-hydroxypropyl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione
CAS 850228-73-8C20H16FNO4
7-Bromo-1-(3-fluorophenyl)-2-(2-hydroxyethyl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione chemical structure, C19H13BrFNO4, CAS 850745-02-7
7-Bromo-1-(3-fluorophenyl)-2-(2-hydroxyethyl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione
CAS 850745-02-7C19H13BrFNO4
1-(3-Bromophenyl)-7-chloro-2-(2-hydroxyethyl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione chemical structure, C19H13BrClNO4, CAS 874463-06-6
1-(3-Bromophenyl)-7-chloro-2-(2-hydroxyethyl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione
CAS 874463-06-6C19H13BrClNO4
1-(3-Bromophenyl)-7-chloro-2-[2-(dimethylamino)ethyl]-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione chemical structure, C21H18BrClN2O3, CAS 631891-42-4
1-(3-Bromophenyl)-7-chloro-2-[2-(dimethylamino)ethyl]-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione
CAS 631891-42-4C21H18BrClN2O3
2-(2-Methoxyethyl)-1-(3-nitrophenyl)-1H-chromeno[2,3-c]pyrrole-3,9-dione chemical structure, C20H16N2O6, CAS 631891-02-6
2-(2-Methoxyethyl)-1-(3-nitrophenyl)-1H-chromeno[2,3-c]pyrrole-3,9-dione
CAS 631891-02-6C20H16N2O6
7-Bromo-1-(2-fluorophenyl)-2-(2-methoxyethyl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione chemical structure, C20H15BrFNO4, CAS 631894-18-3
7-Bromo-1-(2-fluorophenyl)-2-(2-methoxyethyl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione
CAS 631894-18-3C20H15BrFNO4
1-(4-Chlorophenyl)-2-[2-(dimethylamino)ethyl]-7-fluoro-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione chemical structure, C21H18ClFN2O3, CAS 631890-23-8
1-(4-Chlorophenyl)-2-[2-(dimethylamino)ethyl]-7-fluoro-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione
CAS 631890-23-8C21H18ClFN2O3
1-(4-tert-Butylphenyl)-2-[3-(dimethylamino)propyl]-6,7-dimethyl-1H-chromeno[2,3-c]pyrrole-3,9-dione chemical structure, C28H34N2O3, CAS 631889-04-8
1-(4-tert-Butylphenyl)-2-[3-(dimethylamino)propyl]-6,7-dimethyl-1H-chromeno[2,3-c]pyrrole-3,9-dione
CAS 631889-04-8C28H34N2O3
7-Fluoro-2-(2-methoxyethyl)-1-(4-nitrophenyl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione chemical structure, C20H15FN2O6, CAS 631894-94-5
7-Fluoro-2-(2-methoxyethyl)-1-(4-nitrophenyl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione
CAS 631894-94-5C20H15FN2O6
2-[3-(Dimethylamino)propyl]-7-fluoro-1-(3-nitrophenyl)-1H-chromeno[2,3-c]pyrrole-3,9-dione chemical structure, C22H20FN3O5, CAS 631889-43-5
2-[3-(Dimethylamino)propyl]-7-fluoro-1-(3-nitrophenyl)-1H-chromeno[2,3-c]pyrrole-3,9-dione
CAS 631889-43-5C22H20FN3O5
2-Allyl-1-phenyl-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione chemical structure, C20H15NO3, CAS 714261-27-5
2-Allyl-1-phenyl-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione
CAS 714261-27-5C20H15NO3
7-Chloro-1-(4-fluorophenyl)-2-(3-hydroxypropyl)-1H-chromeno[2,3-c]pyrrole-3,9-dione chemical structure, C20H15ClFNO4, CAS 823827-26-5
7-Chloro-1-(4-fluorophenyl)-2-(3-hydroxypropyl)-1H-chromeno[2,3-c]pyrrole-3,9-dione
CAS 823827-26-5C20H15ClFNO4
1-(4-Fluorophenyl)-2,7-dimethyl-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione chemical structure, C19H14FNO3, CAS 849923-19-9
1-(4-Fluorophenyl)-2,7-dimethyl-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione
CAS 849923-19-9C19H14FNO3
2,6,7-Trimethyl-1-(4-propan-2-ylphenyl)-1H-chromeno[2,3-c]pyrrole-3,9-dione chemical structure, C23H23NO3, CAS 874139-83-0
2,6,7-Trimethyl-1-(4-propan-2-ylphenyl)-1H-chromeno[2,3-c]pyrrole-3,9-dione
CAS 874139-83-0C23H23NO3
1-(4-Hydroxyphenyl)-2,6,7-trimethyl-1H-chromeno[2,3-c]pyrrole-3,9-dione chemical structure, C20H17NO4, CAS 874139-89-6
1-(4-Hydroxyphenyl)-2,6,7-trimethyl-1H-chromeno[2,3-c]pyrrole-3,9-dione
CAS 874139-89-6C20H17NO4
1-(3-Bromophenyl)-2,7-dimethyl-1H-chromeno[2,3-c]pyrrole-3,9-dione chemical structure, C19H14BrNO3, CAS 862488-17-3
1-(3-Bromophenyl)-2,7-dimethyl-1H-chromeno[2,3-c]pyrrole-3,9-dione
CAS 862488-17-3C19H14BrNO3
1-(3-Methoxyphenyl)-2-methyl-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione chemical structure, C19H15NO4, CAS 866238-63-3
1-(3-Methoxyphenyl)-2-methyl-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione
CAS 866238-63-3C19H15NO4
1-{3-Nitrophenyl}-2-methyl-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione chemical structure, C18H12N2O5, CAS 849921-76-2
1-{3-Nitrophenyl}-2-methyl-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione
CAS 849921-76-2C18H12N2O5
Methyl 4-(7-chloro-2-methyl-3,9-dioxo-1,2,3,9-tetrahydrochromeno[2,3-c]pyrrol-1-yl)benzoate chemical structure, C20H14ClNO5, CAS 866238-70-2
Methyl 4-(7-chloro-2-methyl-3,9-dioxo-1,2,3,9-tetrahydrochromeno[2,3-c]pyrrol-1-yl)benzoate
CAS 866238-70-2C20H14ClNO5
7-Chloro-1-(4-hydroxyphenyl)-2-methyl-1H-chromeno[2,3-c]pyrrole-3,9-dione chemical structure, C18H12ClNO4, CAS 866238-66-6
7-Chloro-1-(4-hydroxyphenyl)-2-methyl-1H-chromeno[2,3-c]pyrrole-3,9-dione
CAS 866238-66-6C18H12ClNO4