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Murcko scaffold

Ring system with 3 rings and 18 atoms

97 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
97
With full pages
0
Scaffold SMILES

O=C(Nc1nc2c(s1)CNCC2)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1nc2c(s1)CNCC2)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 97 chemicals

4-Acetyl-N-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride chemical structure, C16H18ClN3O2S, CAS 1327518-07-9
4-Acetyl-N-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride
CAS 1327518-07-9C16H18ClN3O2S
3,4-Dimethoxy-N-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride chemical structure, C16H20ClN3O3S, CAS 1327518-09-1
3,4-Dimethoxy-N-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride
CAS 1327518-09-1C16H20ClN3O3S
N-(5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)-3,5-dinitrobenzamide hydrochloride chemical structure, C14H14ClN5O5S, CAS 1330397-90-4
N-(5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)-3,5-dinitrobenzamide hydrochloride
CAS 1330397-90-4C14H14ClN5O5S
4-Chloro-N-(5-ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride chemical structure, C15H17Cl2N3OS, CAS 1327591-04-7
4-Chloro-N-(5-ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride
CAS 1327591-04-7C15H17Cl2N3OS
N-(5-Ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)-4-nitrobenzamide hydrochloride chemical structure, C15H17ClN4O3S, CAS 1327587-70-1
N-(5-Ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)-4-nitrobenzamide hydrochloride
CAS 1327587-70-1C15H17ClN4O3S
N-(5-Ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)-3-nitrobenzamide hydrochloride chemical structure, C15H17ClN4O3S, CAS 1331174-46-9
N-(5-Ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)-3-nitrobenzamide hydrochloride
CAS 1331174-46-9C15H17ClN4O3S
4-(N,N-Diethylsulfamoyl)-N-(5-ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride chemical structure, C19H27ClN4O3S2, CAS 1330397-98-2
4-(N,N-Diethylsulfamoyl)-N-(5-ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride
CAS 1330397-98-2C19H27ClN4O3S2
4-Cyano-N-(5-ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride chemical structure, C16H17ClN4OS, CAS 1330310-44-5
4-Cyano-N-(5-ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride
CAS 1330310-44-5C16H17ClN4OS
4-(N,N-Diisobutylsulfamoyl)-N-(5-ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride chemical structure, C23H35ClN4O3S2, CAS 1329923-63-8
4-(N,N-Diisobutylsulfamoyl)-N-(5-ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride
CAS 1329923-63-8C23H35ClN4O3S2
Methyl 4-((5-ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbamoyl)benzoate hydrochloride chemical structure, C17H20ClN3O3S, CAS 1323394-42-8
Methyl 4-((5-ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbamoyl)benzoate hydrochloride
CAS 1323394-42-8C17H20ClN3O3S
4-(N,N-Diallylsulfamoyl)-N-(5-ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride chemical structure, C21H27ClN4O3S2, CAS 1327517-64-5
4-(N,N-Diallylsulfamoyl)-N-(5-ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride
CAS 1327517-64-5C21H27ClN4O3S2
4-(N,N-Diisobutylsulfamoyl)-N-(5-isopropyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride chemical structure, C24H37ClN4O3S2, CAS 1327208-66-1
4-(N,N-Diisobutylsulfamoyl)-N-(5-isopropyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride
CAS 1327208-66-1C24H37ClN4O3S2
4-Nitro-N-(5-propyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride chemical structure, C16H19ClN4O3S, CAS 1216534-62-1
4-Nitro-N-(5-propyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride
CAS 1216534-62-1C16H19ClN4O3S
3-Nitro-N-(5-propyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride chemical structure, C16H19ClN4O3S, CAS 1331174-91-4
3-Nitro-N-(5-propyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride
CAS 1331174-91-4C16H19ClN4O3S
4-(N,N-Diisobutylsulfamoyl)-N-(5-propyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride chemical structure, C24H37ClN4O3S2, CAS 1329869-75-1
4-(N,N-Diisobutylsulfamoyl)-N-(5-propyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride
CAS 1329869-75-1C24H37ClN4O3S2
Methyl 4-((5-propyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbamoyl)benzoate hydrochloride chemical structure, C18H22ClN3O3S, CAS 1323514-44-8
Methyl 4-((5-propyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbamoyl)benzoate hydrochloride
CAS 1323514-44-8C18H22ClN3O3S
N-(5-Methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)-3-(pentyloxy)benzamide chemical structure, C19H25N3O2S, CAS 1172518-63-6
N-(5-Methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)-3-(pentyloxy)benzamide
CAS 1172518-63-6C19H25N3O2S
3,4-Dimethyl-N-(4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide chemical structure, C15H17N3OS, CAS 1082491-79-9
3,4-Dimethyl-N-(4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide
CAS 1082491-79-9C15H17N3OS
Autogramin-2 chemical structure, C21H27N3O4S, CAS 2375541-45-8
Autogramin-2
CAS 2375541-45-8C21H27N3O4S
4-Chloro-N-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride chemical structure, C14H15Cl2N3OS, CAS 1185094-86-3
4-Chloro-N-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride
CAS 1185094-86-3C14H15Cl2N3OS
3-Chloro-N-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride chemical structure, C14H15Cl2N3OS, CAS 1190010-13-9
3-Chloro-N-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride
CAS 1190010-13-9C14H15Cl2N3OS
N-(5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)-4-nitrobenzamide hydrochloride chemical structure, C14H15ClN4O3S, CAS 1184986-92-2
N-(5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)-4-nitrobenzamide hydrochloride
CAS 1184986-92-2C14H15ClN4O3S
N-(5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)-3-nitrobenzamide hydrochloride chemical structure, C14H15ClN4O3S, CAS 1185074-58-1
N-(5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)-3-nitrobenzamide hydrochloride
CAS 1185074-58-1C14H15ClN4O3S
4-(N,N-Diethylsulfamoyl)-N-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride chemical structure, C18H25ClN4O3S2, CAS 1185050-33-2
4-(N,N-Diethylsulfamoyl)-N-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)benzamide hydrochloride
CAS 1185050-33-2C18H25ClN4O3S2