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Murcko scaffold

Ring system with 3 rings and 19 atoms

35 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
35
With full pages
12
Scaffold SMILES

c1ccc(CSc2nnc(-c3cnccn3)[nH]2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(CSc2nnc(-c3cnccn3)[nH]2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 35 of 35 chemicals

3-[(6-Chloro-2-fluorophenyl)methylthio]-4-methyl-5-pyrazin-2-yl-1,2,4-triazole chemical structure, C14H11ClFN5S, CAS 577964-24-0
3-[(6-Chloro-2-fluorophenyl)methylthio]-4-methyl-5-pyrazin-2-yl-1,2,4-triazole
CAS 577964-24-0C14H11ClFN5S
4-Ethyl-3-[(4-methylphenyl)methylthio]-5-pyrazin-2-yl-1,2,4-triazole chemical structure, C16H17N5S, CAS 577696-67-4
4-Ethyl-3-[(4-methylphenyl)methylthio]-5-pyrazin-2-yl-1,2,4-triazole
CAS 577696-67-4C16H17N5S
3-[(2-Fluorophenyl)methylthio]-4-methyl-5-pyrazin-2-yl-1,2,4-triazole chemical structure, C14H12FN5S, CAS 587012-35-9
3-[(2-Fluorophenyl)methylthio]-4-methyl-5-pyrazin-2-yl-1,2,4-triazole
CAS 587012-35-9C14H12FN5S
3-[(3-Fluorophenyl)methylthio]-4-prop-2-enyl-5-pyrazin-2-yl-1,2,4-triazole chemical structure, C16H14FN5S, CAS 577990-71-7
3-[(3-Fluorophenyl)methylthio]-4-prop-2-enyl-5-pyrazin-2-yl-1,2,4-triazole
CAS 577990-71-7C16H14FN5S
4-Ethyl-3-[(2-methylphenyl)methylthio]-5-pyrazin-2-yl-1,2,4-triazole chemical structure, C16H17N5S, CAS 676644-81-8
4-Ethyl-3-[(2-methylphenyl)methylthio]-5-pyrazin-2-yl-1,2,4-triazole
CAS 676644-81-8C16H17N5S
3-[(4-Fluorophenyl)methylthio]-4-methyl-5-pyrazin-2-yl-1,2,4-triazole chemical structure, C14H12FN5S, CAS 675841-09-5
3-[(4-Fluorophenyl)methylthio]-4-methyl-5-pyrazin-2-yl-1,2,4-triazole
CAS 675841-09-5C14H12FN5S
2-(5-((2-Chlorobenzyl)thio)-4-ethyl-4H-1,2,4-triazol-3-yl)pyrazine chemical structure, C15H14ClN5S, CAS 618427-46-6
2-(5-((2-Chlorobenzyl)thio)-4-ethyl-4H-1,2,4-triazol-3-yl)pyrazine
CAS 618427-46-6C15H14ClN5S
3-[(2,5-Dimethylphenyl)methylthio]-4-methyl-5-pyrazin-2-yl-1,2,4-triazole chemical structure, C16H17N5S, CAS 676151-07-8
3-[(2,5-Dimethylphenyl)methylthio]-4-methyl-5-pyrazin-2-yl-1,2,4-triazole
CAS 676151-07-8C16H17N5S
3-[(4-Fluorophenyl)methylthio]-4-prop-2-enyl-5-pyrazin-2-yl-1,2,4-triazole chemical structure, C16H14FN5S, CAS 674812-65-8
3-[(4-Fluorophenyl)methylthio]-4-prop-2-enyl-5-pyrazin-2-yl-1,2,4-triazole
CAS 674812-65-8C16H14FN5S
3-[(2-Methylphenyl)methylthio]-4-prop-2-enyl-5-pyrazin-2-yl-1,2,4-triazole chemical structure, C17H17N5S, CAS 573949-38-9
3-[(2-Methylphenyl)methylthio]-4-prop-2-enyl-5-pyrazin-2-yl-1,2,4-triazole
CAS 573949-38-9C17H17N5S
3-[(2-Chlorophenyl)methylthio]-4-prop-2-enyl-5-pyrazin-2-yl-1,2,4-triazole chemical structure, C16H14ClN5S, CAS 578002-47-8
3-[(2-Chlorophenyl)methylthio]-4-prop-2-enyl-5-pyrazin-2-yl-1,2,4-triazole
CAS 578002-47-8C16H14ClN5S
4-[(4-Methyl-5-pyrazin-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]benzonitrile chemical structure, C15H12N6S, CAS 578744-46-4
4-[(4-Methyl-5-pyrazin-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]benzonitrile
CAS 578744-46-4C15H12N6S
2-{4-Methyl-5-[(3-methylbenzyl)sulfanyl]-4H-1,2,4-triazol-3-yl}pyrazine chemical structure, C15H15N5S, CAS 578723-41-8
2-{4-Methyl-5-[(3-methylbenzyl)sulfanyl]-4H-1,2,4-triazol-3-yl}pyrazine
CAS 578723-41-8C15H15N5S
3-[(3-Chlorophenyl)methylthio]-4-methyl-5-pyrazin-2-yl-1,2,4-triazole chemical structure, C14H12ClN5S, CAS 585559-72-4
3-[(3-Chlorophenyl)methylthio]-4-methyl-5-pyrazin-2-yl-1,2,4-triazole
CAS 585559-72-4C14H12ClN5S
4-Ethyl-3-[(3-methylphenyl)methylthio]-5-pyrazin-2-yl-1,2,4-triazole chemical structure, C16H17N5S, CAS 587002-33-3
4-Ethyl-3-[(3-methylphenyl)methylthio]-5-pyrazin-2-yl-1,2,4-triazole
CAS 587002-33-3C16H17N5S
2-(5-((2,5-Dimethylbenzyl)thio)-4-ethyl-4H-1,2,4-triazol-3-yl)pyrazine chemical structure, C17H19N5S, CAS 586992-51-0
2-(5-((2,5-Dimethylbenzyl)thio)-4-ethyl-4H-1,2,4-triazol-3-yl)pyrazine
CAS 586992-51-0C17H19N5S
2-[5-(Benzylsulfanyl)-4-methyl-4H-1,2,4-triazol-3-yl]pyrazine chemical structure, C14H13N5S, CAS 579443-35-9
2-[5-(Benzylsulfanyl)-4-methyl-4H-1,2,4-triazol-3-yl]pyrazine
CAS 579443-35-9C14H13N5S
3-[(3-Fluorophenyl)methylthio]-4-methyl-5-pyrazin-2-yl-1,2,4-triazole chemical structure, C14H12FN5S, CAS 587004-31-7
3-[(3-Fluorophenyl)methylthio]-4-methyl-5-pyrazin-2-yl-1,2,4-triazole
CAS 587004-31-7C14H12FN5S
4-Allyl-5-(2-pyrazinyl)-4H-1,2,4-triazol-3-yl 2-chloro-6-fluorobenzyl sulfide chemical structure, C16H13ClFN5S, CAS 676440-76-9
4-Allyl-5-(2-pyrazinyl)-4H-1,2,4-triazol-3-yl 2-chloro-6-fluorobenzyl sulfide
CAS 676440-76-9C16H13ClFN5S
3-[(2,4-Dichlorophenyl)methylthio]-4-methyl-5-pyrazin-2-yl-1,2,4-triazole chemical structure, C14H11Cl2N5S, CAS 587012-98-4
3-[(2,4-Dichlorophenyl)methylthio]-4-methyl-5-pyrazin-2-yl-1,2,4-triazole
CAS 587012-98-4C14H11Cl2N5S
2-(5-((2,4-Dichlorobenzyl)thio)-4-ethyl-4H-1,2,4-triazol-3-yl)pyrazine chemical structure, C15H13Cl2N5S, CAS 573940-77-9
2-(5-((2,4-Dichlorobenzyl)thio)-4-ethyl-4H-1,2,4-triazol-3-yl)pyrazine
CAS 573940-77-9C15H13Cl2N5S
2-(5-((3,4-Dichlorobenzyl)thio)-4-ethyl-4H-1,2,4-triazol-3-yl)pyrazine chemical structure, C15H13Cl2N5S, CAS 618427-38-6
2-(5-((3,4-Dichlorobenzyl)thio)-4-ethyl-4H-1,2,4-triazol-3-yl)pyrazine
CAS 618427-38-6C15H13Cl2N5S
3-[(2,4-Dichlorophenyl)methylthio]-4-prop-2-enyl-5-pyrazin-2-yl-1,2,4-triazole chemical structure, C16H13Cl2N5S, CAS 577987-93-0
3-[(2,4-Dichlorophenyl)methylthio]-4-prop-2-enyl-5-pyrazin-2-yl-1,2,4-triazole
CAS 577987-93-0C16H13Cl2N5S
3-[(3-Bromophenyl)methylthio]-4-methyl-5-pyrazin-2-yl-1,2,4-triazole chemical structure, C14H12BrN5S, CAS 578754-86-6
3-[(3-Bromophenyl)methylthio]-4-methyl-5-pyrazin-2-yl-1,2,4-triazole
CAS 578754-86-6C14H12BrN5S