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Murcko scaffold

Ring system with 3 rings and 20 atoms

50 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
50
With full pages
27
Scaffold SMILES

O=c1c(N=Cc2ccccc2)c[nH]n1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1c(N=Cc2ccccc2)c[nH]n1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 50 chemicals

4-((N-4-Methoxybenzylidene)amino)antipyrine chemical structure, C19H19N3O2, CAS 32061-14-6
4-((N-4-Methoxybenzylidene)amino)antipyrine
CAS 32061-14-6C19H19N3O2
2,3-Dimethyl-4-(m-methoxybenzylideneamino)-1-phenyl-3-pyrazolin-5-one chemical structure, C19H19N3O2, CAS 70318-54-6
2,3-Dimethyl-4-(m-methoxybenzylideneamino)-1-phenyl-3-pyrazolin-5-one
CAS 70318-54-6C19H19N3O2
1,2-Dihydro-4-(((2-hydroxyphenyl)methylene)amino)-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one chemical structure, C18H17N3O2, CAS 30957-66-5
1,2-Dihydro-4-(((2-hydroxyphenyl)methylene)amino)-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one
CAS 30957-66-5C18H17N3O2
4-(4-(Diethylamino)benzylideneamino)antipyrine chemical structure, C22H26N4O, CAS 61098-09-7
4-(4-(Diethylamino)benzylideneamino)antipyrine
CAS 61098-09-7C22H26N4O
4-Benzylideneaminoantipyrine chemical structure, C18H17N3O, CAS 83-17-0
4-Benzylideneaminoantipyrine
CAS 83-17-0C18H17N3O
3H-Pyrazol-3-one, 4-[[(4-chlorophenyl)methylene]amino]-1,2-dihydro-1,5-dimethyl-2-phenyl- chemical structure, C18H16ClN3O, CAS 926020-84-0
3H-Pyrazol-3-one, 4-[[(4-chlorophenyl)methylene]amino]-1,2-dihydro-1,5-dimethyl-2-phenyl-
CAS 926020-84-0C18H16ClN3O
(E)-4-((3-Ethoxy-4-hydroxybenzylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one chemical structure, C20H21N3O3, CAS 879085-06-0
(E)-4-((3-Ethoxy-4-hydroxybenzylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one
CAS 879085-06-0C20H21N3O3
1,5-Dimethyl-2-phenyl-4-{[(E)-(3,4,5-trimethoxyphenyl)methylidene]amino}-1,2-dihydro-3H-pyrazol-3-one chemical structure, C21H23N3O4, CAS 1294452-46-2
1,5-Dimethyl-2-phenyl-4-{[(E)-(3,4,5-trimethoxyphenyl)methylidene]amino}-1,2-dihydro-3H-pyrazol-3-one
CAS 1294452-46-2C21H23N3O4
4-{[(E)-(4-Hydroxy-3-methoxyphenyl)methylidene]amino}-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one chemical structure, C19H19N3O3, CAS 870718-95-9
4-{[(E)-(4-Hydroxy-3-methoxyphenyl)methylidene]amino}-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
CAS 870718-95-9C19H19N3O3
4-{[(E)-(2-Methoxyphenyl)methylidene]amino}-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one chemical structure, C19H19N3O2, CAS 945671-25-0
4-{[(E)-(2-Methoxyphenyl)methylidene]amino}-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
CAS 945671-25-0C19H19N3O2
4-({(E)-[4-(Dimethylamino)phenyl]methylidene}amino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one chemical structure, C20H22N4O, CAS 870821-59-3
4-({(E)-[4-(Dimethylamino)phenyl]methylidene}amino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
CAS 870821-59-3C20H22N4O
1,5-Dimethyl-4-{[(E)-(3-nitrophenyl)methylidene]amino}-2-phenyl-1,2-dihydro-3H-pyrazol-3-one chemical structure, C18H16N4O3, CAS 890138-98-4
1,5-Dimethyl-4-{[(E)-(3-nitrophenyl)methylidene]amino}-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
CAS 890138-98-4C18H16N4O3
(E)-1,5-Dimethyl-4-((4-methylbenzylidene)amino)-2-phenyl-1H-pyrazol-3(2H)-one chemical structure, C19H19N3O, CAS 936841-86-0
(E)-1,5-Dimethyl-4-((4-methylbenzylidene)amino)-2-phenyl-1H-pyrazol-3(2H)-one
CAS 936841-86-0C19H19N3O
4-{[(E)-(4-Isopropylphenyl)methylidene]amino}-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one chemical structure, C21H23N3O, CAS 198220-47-2
4-{[(E)-(4-Isopropylphenyl)methylidene]amino}-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
CAS 198220-47-2C21H23N3O
4-{[(E)-(4-Fluorophenyl)methylidene]amino}-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one chemical structure, C18H16FN3O, CAS 72425-87-7
4-{[(E)-(4-Fluorophenyl)methylidene]amino}-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
CAS 72425-87-7C18H16FN3O
4-[(2-Ethoxyphenyl)methylideneamino]-1,5-dimethyl-2-phenylpyrazol-3-one chemical structure, C20H21N3O2, CAS 329934-34-1
4-[(2-Ethoxyphenyl)methylideneamino]-1,5-dimethyl-2-phenylpyrazol-3-one
CAS 329934-34-1C20H21N3O2
4-[(4-Ethoxybenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one chemical structure, C20H21N3O2, CAS 1447968-74-2
4-[(4-Ethoxybenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
CAS 1447968-74-2C20H21N3O2
(E)-4-((5-Chloro-2-hydroxybenzylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one chemical structure, C18H16ClN3O2, CAS 149652-80-2
(E)-4-((5-Chloro-2-hydroxybenzylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one
CAS 149652-80-2C18H16ClN3O2
(Z)-4-((2-Fluorobenzylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one chemical structure, C18H16FN3O, CAS 89093-69-6
(Z)-4-((2-Fluorobenzylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one
CAS 89093-69-6C18H16FN3O
4-[(2-Chlorobenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one chemical structure, C18H16ClN3O, CAS 926020-85-1
4-[(2-Chlorobenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
CAS 926020-85-1C18H16ClN3O
(E)-4-((3-Chlorobenzylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one chemical structure, C18H16ClN3O, CAS 72425-90-2
(E)-4-((3-Chlorobenzylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one
CAS 72425-90-2C18H16ClN3O
(E)-4-((4-Ethylbenzylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one chemical structure, C20H21N3O, CAS 324067-76-7
(E)-4-((4-Ethylbenzylidene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one
CAS 324067-76-7C20H21N3O
4-{[(1E)-(3-Allyl-2-hydroxyphenyl)methylene]amino}-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one chemical structure, C21H21N3O2, CAS 317335-46-9
4-{[(1E)-(3-Allyl-2-hydroxyphenyl)methylene]amino}-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
CAS 317335-46-9C21H21N3O2
4-[(3-Hydroxy-4-methoxybenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one chemical structure, C19H19N3O3, CAS 125298-64-8
4-[(3-Hydroxy-4-methoxybenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
CAS 125298-64-8C19H19N3O3