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Murcko scaffold

2-[(4-Hydroxy-6-phenylpyrimidin-2-yl)sulfanyl]-N-phenylacetamide scaffold

23 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
24
Chemicals
23
With full pages
3
Scaffold SMILES

O=C(CSc1nc(-c2ccccc2)cc(=O)[nH]1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-[(4-Hydroxy-6-phenylpyrimidin-2-yl)sulfanyl]-N-phenylacetamide page
Murcko scaffold O=C(CSc1nc(-c2ccccc2)cc(=O)[nH]1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

N-(2-Methoxyphenyl)-2-((6-oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)thio)acetamide chemical structure, C19H17N3O3S, CAS 518017-71-5
N-(2-Methoxyphenyl)-2-((6-oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)thio)acetamide
CAS 518017-71-5C19H17N3O3S
N-(3-Chloro-2-methylphenyl)-2-[(4-hydroxy-6-phenylpyrimidin-2-yl)sulfanyl]acetamide chemical structure, C19H16ClN3O2S, CAS 306285-11-0
N-(3-Chloro-2-methylphenyl)-2-[(4-hydroxy-6-phenylpyrimidin-2-yl)sulfanyl]acetamide
CAS 306285-11-0C19H16ClN3O2S
2-[(6-Oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C19H14F3N3O2S, CAS 602290-22-2
2-[(6-Oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 602290-22-2C19H14F3N3O2S
2-[[5-Cyano-6-(3-methoxyphenyl)-4-oxo-1H-pyrimidin-2-yl]sulfanyl]-N-(4-sulfamoylphenyl)acetamide chemical structure, C20H17N5O5S2, CAS 440109-20-6
2-[[5-Cyano-6-(3-methoxyphenyl)-4-oxo-1H-pyrimidin-2-yl]sulfanyl]-N-(4-sulfamoylphenyl)acetamide
CAS 440109-20-6C20H17N5O5S2
N-(2-Methoxy-5-methylphenyl)-2-[(4-oxo-6-phenyl-1H-pyrimidin-2-yl)sulfanyl]acetamide chemical structure, C20H19N3O3S, CAS 3920-47-6
N-(2-Methoxy-5-methylphenyl)-2-[(4-oxo-6-phenyl-1H-pyrimidin-2-yl)sulfanyl]acetamide
CAS 3920-47-6C20H19N3O3S
2-[(4-Hydroxy-6-phenylpyrimidin-2-yl)sulfanyl]-N-phenylacetamide chemical structure, C18H15N3O2S, CAS 351013-70-2
2-[(4-Hydroxy-6-phenylpyrimidin-2-yl)sulfanyl]-N-phenylacetamide
CAS 351013-70-2C18H15N3O2S
N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-[(4-oxo-6-phenyl-1H-pyrimidin-2-yl)sulfanyl]acetamide chemical structure, C19H13ClF3N3O2S, CAS 351163-86-5
N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-[(4-oxo-6-phenyl-1H-pyrimidin-2-yl)sulfanyl]acetamide
CAS 351163-86-5C19H13ClF3N3O2S
N-(2-Chloro-5-(trifluoromethyl)phenyl)-2-((6-oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)thio)acetamide chemical structure, C19H13ClF3N3O2S, CAS 602290-56-2
N-(2-Chloro-5-(trifluoromethyl)phenyl)-2-((6-oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)thio)acetamide
CAS 602290-56-2C19H13ClF3N3O2S
N-(3-Methylphenyl)-2-[(4-oxo-6-phenyl-1H-pyrimidin-2-yl)sulfanyl]acetamide chemical structure, C19H17N3O2S, CAS 496960-64-6
N-(3-Methylphenyl)-2-[(4-oxo-6-phenyl-1H-pyrimidin-2-yl)sulfanyl]acetamide
CAS 496960-64-6C19H17N3O2S
2-{[5-Cyano-4-(3-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}-N-(4-sulfamoylphenyl)butanamide chemical structure, C22H21N5O5S2, CAS 440109-22-8
2-{[5-Cyano-4-(3-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}-N-(4-sulfamoylphenyl)butanamide
CAS 440109-22-8C22H21N5O5S2
N-(3-Methoxyphenyl)-2-[(6-oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)sulfanyl]acetamide chemical structure, C19H17N3O3S, CAS 433243-41-5
N-(3-Methoxyphenyl)-2-[(6-oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)sulfanyl]acetamide
CAS 433243-41-5C19H17N3O3S
2-[(4-Hydroxy-6-phenylpyrimidin-2-yl)sulfanyl]-N-(4-methylphenyl)acetamide chemical structure, C19H17N3O2S, CAS 6510-07-2
2-[(4-Hydroxy-6-phenylpyrimidin-2-yl)sulfanyl]-N-(4-methylphenyl)acetamide
CAS 6510-07-2C19H17N3O2S
2-[(4-Oxo-6-phenyl-1H-pyrimidin-2-yl)sulfanyl]-N-[2-(trifluoromethyl)phenyl]acetamide chemical structure, C19H14F3N3O2S, CAS 518017-69-1
2-[(4-Oxo-6-phenyl-1H-pyrimidin-2-yl)sulfanyl]-N-[2-(trifluoromethyl)phenyl]acetamide
CAS 518017-69-1C19H14F3N3O2S
2-((5-Cyano-4-(4-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(4-sulfamoylphenyl)butanamide chemical structure, C22H21N5O5S2, CAS 404910-49-2
2-((5-Cyano-4-(4-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(4-sulfamoylphenyl)butanamide
CAS 404910-49-2C22H21N5O5S2
N-(3-Chlorophenyl)-2-[(6-oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)thio]acetamide chemical structure, C18H14ClN3O2S, CAS 602290-07-3
N-(3-Chlorophenyl)-2-[(6-oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)thio]acetamide
CAS 602290-07-3C18H14ClN3O2S
N-(4-Acetylphenyl)-2-((6-oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)thio)acetamide chemical structure, C20H17N3O3S, CAS 518017-70-4
N-(4-Acetylphenyl)-2-((6-oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)thio)acetamide
CAS 518017-70-4C20H17N3O3S
N-[4-(Dimethylamino)phenyl]-2-[(6-oxo-4-phenyl-1H-pyrimidin-2-yl)sulfanyl]acetamide chemical structure, C20H20N4O2S, CAS 602291-51-0
N-[4-(Dimethylamino)phenyl]-2-[(6-oxo-4-phenyl-1H-pyrimidin-2-yl)sulfanyl]acetamide
CAS 602291-51-0C20H20N4O2S
N-(2-Ethoxyphenyl)-2-[(6-oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)sulfanyl]acetamide chemical structure, C20H19N3O3S, CAS 518017-86-2
N-(2-Ethoxyphenyl)-2-[(6-oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)sulfanyl]acetamide
CAS 518017-86-2C20H19N3O3S
2-{[4-(4-tert-Butylphenyl)-5-cyano-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}-N-(2-methoxyphenyl)acetamide chemical structure, C24H24N4O3S, CAS 927969-24-2
2-{[4-(4-tert-Butylphenyl)-5-cyano-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}-N-(2-methoxyphenyl)acetamide
CAS 927969-24-2C24H24N4O3S
4-(2-((6-Oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)thio)acetamido)benzamide chemical structure, C19H16N4O3S, CAS 899965-65-2
4-(2-((6-Oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)thio)acetamido)benzamide
CAS 899965-65-2C19H16N4O3S
N-(2,4-Difluorophenyl)-2-((6-oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)thio)acetamide chemical structure, C18H13F2N3O2S, CAS 899755-16-9
N-(2,4-Difluorophenyl)-2-((6-oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)thio)acetamide
CAS 899755-16-9C18H13F2N3O2S
2-((6-Oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)thio)-N-(4-(trifluoromethyl)phenyl)acetamide chemical structure, C19H14F3N3O2S, CAS 899965-69-6
2-((6-Oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)thio)-N-(4-(trifluoromethyl)phenyl)acetamide
CAS 899965-69-6C19H14F3N3O2S
hCAIX-IN-20 chemical structure, C19H13Cl2N5O4S2, CAS 3047054-26-9
hCAIX-IN-20
CAS 3047054-26-9C19H13Cl2N5O4S2