Murcko scaffold
Ring system with 3 rings and 23 atoms
65 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 23
- Chemicals
- 65
- With full pages
- 27
Scaffold SMILES
O=C(CSc1cccc(-c2ccccc2)n1)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 65 chemicals
![2-[3-Cyano-6-(3,4-dimethoxyphenyl)pyridin-2-yl]sulfanyl-N-(4-methylphenyl)acetamide chemical structure, C23H21N3O3S, CAS 488119-47-7](/s/JMRMXHZIBSYIKK-UHFFFAOYSA-N.svg)
2-[3-Cyano-6-(3,4-dimethoxyphenyl)pyridin-2-yl]sulfanyl-N-(4-methylphenyl)acetamide
CAS 488119-47-7C23H21N3O3S
![2-[3-Cyano-6-(3,4-dimethoxyphenyl)pyridin-2-yl]sulfanyl-N-(2-methylphenyl)acetamide chemical structure, C23H21N3O3S, CAS 489402-23-5](/s/DSQRHAPGGORRHE-UHFFFAOYSA-N.svg)
2-[3-Cyano-6-(3,4-dimethoxyphenyl)pyridin-2-yl]sulfanyl-N-(2-methylphenyl)acetamide
CAS 489402-23-5C23H21N3O3S
![2-[3-Cyano-6-(3,4-dimethoxyphenyl)pyridin-2-yl]sulfanyl-N-(2,5-dichlorophenyl)acetamide chemical structure, C22H17Cl2N3O3S, CAS 488733-03-5](/s/ZYODUDIQQOOBLE-UHFFFAOYSA-N.svg)
2-[3-Cyano-6-(3,4-dimethoxyphenyl)pyridin-2-yl]sulfanyl-N-(2,5-dichlorophenyl)acetamide
CAS 488733-03-5C22H17Cl2N3O3S
![2-[3-Cyano-6-(3,4-dimethoxyphenyl)pyridin-2-yl]sulfanyl-N-(2,5-dimethylphenyl)acetamide chemical structure, C24H23N3O3S, CAS 487035-40-5](/s/VWJLRCZVZDACSA-UHFFFAOYSA-N.svg)
2-[3-Cyano-6-(3,4-dimethoxyphenyl)pyridin-2-yl]sulfanyl-N-(2,5-dimethylphenyl)acetamide
CAS 487035-40-5C24H23N3O3S
![N-(2-Bromo-4-methylphenyl)-2-[3-cyano-6-(3,4-dimethoxyphenyl)pyridin-2-yl]sulfanylacetamide chemical structure, C23H20BrN3O3S, CAS 500145-66-4](/s/NOWROJLKKLKPLB-UHFFFAOYSA-N.svg)
N-(2-Bromo-4-methylphenyl)-2-[3-cyano-6-(3,4-dimethoxyphenyl)pyridin-2-yl]sulfanylacetamide
CAS 500145-66-4C23H20BrN3O3S
![2-[3-Cyano-6-(3,4-dimethoxyphenyl)pyridin-2-yl]sulfanyl-N-(3-ethoxyphenyl)acetamide chemical structure, C24H23N3O4S, CAS 488723-16-6](/s/NGJHVAODRSPUBP-UHFFFAOYSA-N.svg)
2-[3-Cyano-6-(3,4-dimethoxyphenyl)pyridin-2-yl]sulfanyl-N-(3-ethoxyphenyl)acetamide
CAS 488723-16-6C24H23N3O4S
![N-(3-Chloro-4-fluorophenyl)-2-[3-cyano-6-(3,4-dimethoxyphenyl)pyridin-2-yl]sulfanylacetamide chemical structure, C22H17ClFN3O3S, CAS 497244-81-2](/s/XYLMEYTXIWTDQO-UHFFFAOYSA-N.svg)
N-(3-Chloro-4-fluorophenyl)-2-[3-cyano-6-(3,4-dimethoxyphenyl)pyridin-2-yl]sulfanylacetamide
CAS 497244-81-2C22H17ClFN3O3S
![2-[3-Cyano-6-(3,4-dimethoxyphenyl)pyridin-2-yl]sulfanyl-N-(2,4-dimethoxyphenyl)acetamide chemical structure, C24H23N3O5S, CAS 371211-15-3](/s/QMIJUVXOBAGVLZ-UHFFFAOYSA-N.svg)
2-[3-Cyano-6-(3,4-dimethoxyphenyl)pyridin-2-yl]sulfanyl-N-(2,4-dimethoxyphenyl)acetamide
CAS 371211-15-3C24H23N3O5S
![2-[3-Cyano-6-(3,4-dimethoxyphenyl)pyridin-2-yl]sulfanyl-N-(4-methylsulfanylphenyl)acetamide chemical structure, C23H21N3O3S2, CAS 488851-78-1](/s/RZRRGDUMYFNRMN-UHFFFAOYSA-N.svg)
2-[3-Cyano-6-(3,4-dimethoxyphenyl)pyridin-2-yl]sulfanyl-N-(4-methylsulfanylphenyl)acetamide
CAS 488851-78-1C23H21N3O3S2
![2-{[3-Cyano-6-(4-methoxyphenyl)pyridin-2-yl]sulfanyl}-N-(3-methylphenyl)acetamide chemical structure, C22H19N3O2S, CAS 488746-80-1](/s/OPJLWJDMXJLQKM-UHFFFAOYSA-N.svg)
2-{[3-Cyano-6-(4-methoxyphenyl)pyridin-2-yl]sulfanyl}-N-(3-methylphenyl)acetamide
CAS 488746-80-1C22H19N3O2S
![N-(4-Bromophenyl)-2-[3-cyano-6-(4-methoxyphenyl)pyridin-2-yl]sulfanylacetamide chemical structure, C21H16BrN3O2S, CAS 445269-29-4](/s/RXQCFWKQTYVYOL-UHFFFAOYSA-N.svg)
N-(4-Bromophenyl)-2-[3-cyano-6-(4-methoxyphenyl)pyridin-2-yl]sulfanylacetamide
CAS 445269-29-4C21H16BrN3O2S
![N-(2-Bromophenyl)-2-[3-cyano-6-(4-methoxyphenyl)pyridin-2-yl]sulfanylacetamide chemical structure, C21H16BrN3O2S, CAS 445269-30-7](/s/LXUYIJZPQVRDEM-UHFFFAOYSA-N.svg)
N-(2-Bromophenyl)-2-[3-cyano-6-(4-methoxyphenyl)pyridin-2-yl]sulfanylacetamide
CAS 445269-30-7C21H16BrN3O2S
![2-[3-Cyano-6-(4-methoxyphenyl)pyridin-2-yl]sulfanyl-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C22H16F3N3O2S, CAS 488121-37-5](/s/YRQJZMSDFJVHIA-UHFFFAOYSA-N.svg)
2-[3-Cyano-6-(4-methoxyphenyl)pyridin-2-yl]sulfanyl-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 488121-37-5C22H16F3N3O2S
![2-[3-Cyano-6-(4-methoxyphenyl)pyridin-2-yl]sulfanyl-N-(3,4-dimethoxyphenyl)acetamide chemical structure, C23H21N3O4S, CAS 500271-99-8](/s/YKXKQRXPVOLEIX-UHFFFAOYSA-N.svg)
2-[3-Cyano-6-(4-methoxyphenyl)pyridin-2-yl]sulfanyl-N-(3,4-dimethoxyphenyl)acetamide
CAS 500271-99-8C23H21N3O4S
![N-(5-Chloro-2-methylphenyl)-2-[3-cyano-6-(4-methoxyphenyl)pyridin-2-yl]sulfanylacetamide chemical structure, C22H18ClN3O2S, CAS 489402-73-5](/s/UKCDMOYBPQVHGK-UHFFFAOYSA-N.svg)
N-(5-Chloro-2-methylphenyl)-2-[3-cyano-6-(4-methoxyphenyl)pyridin-2-yl]sulfanylacetamide
CAS 489402-73-5C22H18ClN3O2S
![N-(4-Bromophenyl)-2-[3-cyano-6-(3-methoxyphenyl)pyridin-2-yl]sulfanylacetamide chemical structure, C21H16BrN3O2S, CAS 445269-35-2](/s/VXSXEDMXNLRZRV-UHFFFAOYSA-N.svg)
N-(4-Bromophenyl)-2-[3-cyano-6-(3-methoxyphenyl)pyridin-2-yl]sulfanylacetamide
CAS 445269-35-2C21H16BrN3O2S
![N-(2-Bromophenyl)-2-[3-cyano-6-(3-methoxyphenyl)pyridin-2-yl]sulfanylacetamide chemical structure, C21H16BrN3O2S, CAS 445269-36-3](/s/UYTWCIWWSQCFQG-UHFFFAOYSA-N.svg)
N-(2-Bromophenyl)-2-[3-cyano-6-(3-methoxyphenyl)pyridin-2-yl]sulfanylacetamide
CAS 445269-36-3C21H16BrN3O2S
![N-(3-Acetamidophenyl)-2-[3-cyano-6-(3-methoxyphenyl)pyridin-2-yl]sulfanylacetamide chemical structure, C23H20N4O3S, CAS 445269-37-4](/s/FENWUYSCSGQUDH-UHFFFAOYSA-N.svg)
N-(3-Acetamidophenyl)-2-[3-cyano-6-(3-methoxyphenyl)pyridin-2-yl]sulfanylacetamide
CAS 445269-37-4C23H20N4O3S
![2-[3-Cyano-6-(3-methoxyphenyl)pyridin-2-yl]sulfanyl-N-(4-methoxyphenyl)acetamide chemical structure, C22H19N3O3S, CAS 445269-38-5](/s/DSQOQMIOKONMTR-UHFFFAOYSA-N.svg)
2-[3-Cyano-6-(3-methoxyphenyl)pyridin-2-yl]sulfanyl-N-(4-methoxyphenyl)acetamide
CAS 445269-38-5C22H19N3O3S
![2-[3-Cyano-6-(3-methoxyphenyl)pyridin-2-yl]sulfanyl-N-(4-ethoxyphenyl)acetamide chemical structure, C23H21N3O3S, CAS 445269-39-6](/s/PVKNUHAXJVHRGV-UHFFFAOYSA-N.svg)
2-[3-Cyano-6-(3-methoxyphenyl)pyridin-2-yl]sulfanyl-N-(4-ethoxyphenyl)acetamide
CAS 445269-39-6C23H21N3O3S
![2-[3-Cyano-6-(3-methoxyphenyl)pyridin-2-yl]sulfanyl-N-(2-methoxy-5-methylphenyl)acetamide chemical structure, C23H21N3O3S, CAS 489413-83-4](/s/VLSYXJSLVYFXOI-UHFFFAOYSA-N.svg)
2-[3-Cyano-6-(3-methoxyphenyl)pyridin-2-yl]sulfanyl-N-(2-methoxy-5-methylphenyl)acetamide
CAS 489413-83-4C23H21N3O3S
![N-(4-Chloro-2-fluorophenyl)-2-[3-cyano-6-(3-methoxyphenyl)pyridin-2-yl]sulfanylacetamide chemical structure, C21H15ClFN3O2S, CAS 445269-47-6](/s/TUCPXODRVCCRDS-UHFFFAOYSA-N.svg)
N-(4-Chloro-2-fluorophenyl)-2-[3-cyano-6-(3-methoxyphenyl)pyridin-2-yl]sulfanylacetamide
CAS 445269-47-6C21H15ClFN3O2S
![2-[3-Cyano-6-(3-methoxyphenyl)pyridin-2-yl]sulfanyl-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C22H16F3N3O2S, CAS 445269-51-2](/s/OKACLCPARSTMFC-UHFFFAOYSA-N.svg)
2-[3-Cyano-6-(3-methoxyphenyl)pyridin-2-yl]sulfanyl-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 445269-51-2C22H16F3N3O2S
![2-[3-Cyano-6-(3-methoxyphenyl)pyridin-2-yl]sulfanyl-N-(2,3-dichlorophenyl)acetamide chemical structure, C21H15Cl2N3O2S, CAS 445269-54-5](/s/IUNUTQZWCFMOIC-UHFFFAOYSA-N.svg)
2-[3-Cyano-6-(3-methoxyphenyl)pyridin-2-yl]sulfanyl-N-(2,3-dichlorophenyl)acetamide
CAS 445269-54-5C21H15Cl2N3O2S
- 2-[3-Cyano-6-(3-methoxyphenyl)pyridin-2-yl]sulfanyl-N-(3,5-dichlorophenyl)acetamide445269-55-6C21H15Cl2N3O2S
- 2-[3-Cyano-6-(3-methoxyphenyl)pyridin-2-yl]sulfanyl-N-(4-methylsulfanylphenyl)acetamide488095-84-7C22H19N3O2S2
- 2-[3-Cyano-6-(3-methoxyphenyl)pyridin-2-yl]sulfanyl-N-(3,4,5-trimethoxyphenyl)acetamide445380-75-6C24H23N3O5S
- N-(4-Acetylphenyl)-2-[3-cyano-6-(3-methoxyphenyl)pyridin-2-yl]sulfanylacetamide445380-83-6C23H19N3O3S
- 2-[3-Cyano-6-(4-methoxyphenyl)-4-(trifluoromethyl)pyridin-2-yl]sulfanyl-N-(3,4,5-trimethoxyphenyl)acetamide625377-98-2C25H22F3N3O5S
- Methyl 2-[({[3-cyano-6-(4-methoxyphenyl)-2-pyridinyl]sulfanyl}acetyl)amino]benzoate664999-88-6C23H19N3O4S
- 2-({6-[3,4-Bis(methyloxy)phenyl]-3-cyanopyridin-2-yl}sulfanyl)-N-(3-methylphenyl)acetamide371206-79-0C23H21N3O3S
- 2-[3-Cyano-6-(3-methoxyphenyl)pyridin-2-yl]sulfanyl-N-(5-fluoro-2-methylphenyl)acetamide445269-56-7C22H18FN3O2S
- 2-{[3-Cyano-6-(4-methylphenyl)-4-(trifluoromethyl)-2-pyridinyl]sulfanyl}-N-(4-ethoxyphenyl)acetamide618074-03-6C24H20F3N3O2S
- 2-((6-(4-CL-PH)-3-Cyano-4-(trifluoromethyl)-2-pyridinyl)thio)-N-phenylacetamide617697-44-6C21H13ClF3N3OS
- 2-[3-Cyano-6-(4-methoxyphenyl)pyridin-2-yl]sulfanyl-N-(3,4,5-trimethoxyphenyl)acetamide488800-69-7C24H23N3O5S
- 2-((6-(4-Chlorophenyl)-3-cyano-4-(trifluoromethyl)-2-pyridinyl)sulfanyl)-N-(4-methoxyphenyl)acetamide617697-48-0C22H15ClF3N3O2S
- N-(2-Chlorophenyl)-2-[3-cyano-6-(3,4-dimethoxyphenyl)pyridin-2-yl]sulfanylacetamide500275-60-5C22H18ClN3O3S
- 2-{[3-Cyano-6-(4-fluorophenyl)-4-(trifluoromethyl)-2-pyridinyl]sulfanyl}-N-(3-methylphenyl)acetamide618077-41-1C22H15F4N3OS
- 2-((3-Cyano-6-(4-methylphenyl)-4-(trifluoromethyl)-2-pyridinyl)sulfanyl)-N-phenylacetamide618075-74-4C22H16F3N3OS
- 2-((6-(4-Butoxyphenyl)-3-cyano-4-(trifluoromethyl)-2-pyridinyl)sulfanyl)-N-(3-methylphenyl)acetamide617697-65-1C26H24F3N3O2S
- 2-{[3-Cyano-6-(4-fluorophenyl)-4-(trifluoromethyl)-2-pyridinyl]sulfanyl}-N-(4-ethoxyphenyl)acetamide618077-44-4C23H17F4N3O2S
- N-(4-Chlorophenyl)-2-((3-cyano-6-(4-methylphenyl)-4-(trifluoromethyl)-2-pyridinyl)sulfanyl)acetamide608494-99-1C22H15ClF3N3OS
- 2-{[6-(4-Butoxyphenyl)-3-cyano-4-(trifluoromethyl)-2-pyridinyl]sulfanyl}-N-phenylacetamide617697-64-0C25H22F3N3O2S
- N-(3-Chloro-4-methylphenyl)-2-[3-cyano-6-(3,4-dimethoxyphenyl)pyridin-2-yl]sulfanylacetamide499117-40-7C23H20ClN3O3S
- 2-[3-Cyano-6-(3,4-dimethoxyphenyl)pyridin-2-yl]sulfanyl-N-[3-(trifluoromethyl)phenyl]acetamide487031-24-3C23H18F3N3O3S
- Ethyl 4-((((6-(4-chlorophenyl)-3-cyano-4-(trifluoromethyl)-2-pyridinyl)sulfanyl)acetyl)amino)benzoate617697-46-8C24H17ClF3N3O3S
- 2-{[3-Cyano-6-(4-methoxyphenyl)-4-(trifluoromethyl)-2-pyridinyl]sulfanyl}-N-phenylacetamide617697-60-6C22H16F3N3O2S
- 2-{[3-Cyano-6-(4-methylphenyl)-4-(trifluoromethyl)-2-pyridinyl]sulfanyl}-N-(2,5-dimethylphenyl)acetamide618072-61-0C24H20F3N3OS
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(COc1ccccc1)Nc1cccc(-c2cccnn2)c17 chemicals
O=C1CC(c2ccccc2)C=C(SCC(=O)Nc2ccccc2)N15 chemicals
O=C(CSc1nccn(-c2ccccc2)c1=O)Nc1ccccc14 chemicals
c1ccc(OCCNc2cccc(N3CCNCC3)c2)cc14 chemicals![Scaffold O=C(CSc1nc(-c2ccccc2)cc(=O)[nH]1)Nc1ccccc1](/scaffold/FYNXMRMMHIZSOV-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nc(-c2ccccc2)cc(=O)[nH]1)Nc1ccccc13 chemicals
O=C(Cn1nc(-c2ccccc2)ccc1=O)NCc1ccccc13 chemicals
c1ccc(OCCNc2cccc(N3CCOCC3)c2)cc12 chemicals
c1ccc(OCCNc2cccc(N3CCCCC3)c2)cc12 chemicals
O=C(NNC(=O)c1ccccc1)C1=NN(c2ccccc2)C(=O)CC12 chemicals
O=C(CSC1=CC(c2ccccc2)C=CN1)Nc1ccccc11 chemical
O=C(C=Cc1ccccc1)Nc1ccnc(-c2ccncc2)n11 chemical
O=C(NCCc1ccccc1)C1CCCN(c2ncccn2)C11 chemical