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Murcko scaffold

Ring system with 3 rings and 20 atoms

21 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 20
Chemicals: 21
With full pages: 7

Scaffold SMILES

O=C(Nc1cc(-c2ccccc2)cs1)C1CC=CCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(Nc1cc(-c2ccccc2)cs1)C1CC=CCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 21 of 21 chemicals

6-[(3-Methoxycarbonyl-4-phenylthiophen-2-yl)carbamoyl]cyclohex-3-ene-1-carboxylic acid chemical structure, C20H19NO5S, CAS 350998-61-7

6-[(3-Methoxycarbonyl-4-phenylthiophen-2-yl)carbamoyl]cyclohex-3-ene-1-carboxylic acid

CAS 350998-61-7C₂₀H₁₉NO₅S

6-({[3-(Ethoxycarbonyl)-4-(4-methylphenyl)-2-thienyl]amino}carbonyl)-3-cyclohexene-1-carboxylic acid chemical structure, C22H23NO5S, CAS 350998-49-1

6-({[3-(Ethoxycarbonyl)-4-(4-methylphenyl)-2-thienyl]amino}carbonyl)-3-cyclohexene-1-carboxylic acid

CAS 350998-49-1C₂₂H₂₃NO₅S

6-({[3-(Isopropoxycarbonyl)-4-(4-methylphenyl)thien-2-yl]amino}carbonyl)cyclohex-3-ene-1-carboxylic acid chemical structure, C23H25NO5S, CAS 351000-50-5

6-({[3-(Isopropoxycarbonyl)-4-(4-methylphenyl)thien-2-yl]amino}carbonyl)cyclohex-3-ene-1-carboxylic acid

CAS 351000-50-5C₂₃H₂₅NO₅S

6-({[3-(Ethoxycarbonyl)-4-(4-fluorophenyl)-2-thienyl]amino}carbonyl)-3-cyclohexene-1-carboxylic acid chemical structure, C21H20FNO5S, CAS 350999-74-5

6-({[3-(Ethoxycarbonyl)-4-(4-fluorophenyl)-2-thienyl]amino}carbonyl)-3-cyclohexene-1-carboxylic acid

CAS 350999-74-5C₂₁H₂₀FNO₅S

6-{[3-(Ethoxycarbonyl)-4-(4-methoxyphenyl)thiophen-2-yl]carbamoyl}cyclohex-3-ene-1-carboxylic acid chemical structure, C22H23NO6S, CAS 351000-41-4

6-{[3-(Ethoxycarbonyl)-4-(4-methoxyphenyl)thiophen-2-yl]carbamoyl}cyclohex-3-ene-1-carboxylic acid

CAS 351000-41-4C₂₂H₂₃NO₆S

6-{[3-(Ethoxycarbonyl)-4-(4-fluorophenyl)-5-methylthiophen-2-yl]carbamoyl}cyclohex-3-ene-1-carboxylic acid chemical structure, C22H22FNO5S, CAS 444905-71-9

6-{[3-(Ethoxycarbonyl)-4-(4-fluorophenyl)-5-methylthiophen-2-yl]carbamoyl}cyclohex-3-ene-1-carboxylic acid

CAS 444905-71-9C₂₂H₂₂FNO₅S

6-{[4-(4-Chlorophenyl)-3-(ethoxycarbonyl)-5-methylthiophen-2-yl]carbamoyl}cyclohex-3-ene-1-carboxylic acid chemical structure, C22H22ClNO5S, CAS 524927-71-7

6-{[4-(4-Chlorophenyl)-3-(ethoxycarbonyl)-5-methylthiophen-2-yl]carbamoyl}cyclohex-3-ene-1-carboxylic acid

CAS 524927-71-7C₂₂H₂₂ClNO₅S

6-[[4-(4-Fluorophenyl)-5-methyl-3-propoxycarbonylthiophen-2-yl]carbamoyl]cyclohex-3-ene-1-carboxylic acid chemical structure, C23H24FNO5S, CAS 524928-14-1

6-[[4-(4-Fluorophenyl)-5-methyl-3-propoxycarbonylthiophen-2-yl]carbamoyl]cyclohex-3-ene-1-carboxylic acid

CAS 524928-14-1C₂₃H₂₄FNO₅S

6-[[4-(4-tert-Butylphenyl)-3-methoxycarbonyl-5-methylthiophen-2-yl]carbamoyl]cyclohex-3-ene-1-carboxylic acid chemical structure, C25H29NO5S, CAS 515176-98-4

6-[[4-(4-tert-Butylphenyl)-3-methoxycarbonyl-5-methylthiophen-2-yl]carbamoyl]cyclohex-3-ene-1-carboxylic acid

CAS 515176-98-4C₂₅H₂₉NO₅S

6-({[4-(4-sec-Butylphenyl)-3-cyano-5-methyl-2-thienyl]amino}carbonyl)-3,4-dimethyl-3-cyclohexene-1-carboxylic acid chemical structure, C26H30N2O3S, CAS 492426-04-7

6-({[4-(4-sec-Butylphenyl)-3-cyano-5-methyl-2-thienyl]amino}carbonyl)-3,4-dimethyl-3-cyclohexene-1-carboxylic acid

CAS 492426-04-7C₂₆H₃₀N₂O₃S

6-{[4-(2,5-Dimethylphenyl)-3-(ethoxycarbonyl)-5-methylthiophen-2-yl]carbamoyl}cyclohex-3-ene-1-carboxylic acid chemical structure, C24H27NO5S, CAS 445002-66-4

6-{[4-(2,5-Dimethylphenyl)-3-(ethoxycarbonyl)-5-methylthiophen-2-yl]carbamoyl}cyclohex-3-ene-1-carboxylic acid

CAS 445002-66-4C₂₄H₂₇NO₅S

6-[[4-(3,4-Dimethylphenyl)-3-ethoxycarbonyl-5-methylthiophen-2-yl]carbamoyl]cyclohex-3-ene-1-carboxylic acid chemical structure, C24H27NO5S, CAS 438537-98-5

6-[[4-(3,4-Dimethylphenyl)-3-ethoxycarbonyl-5-methylthiophen-2-yl]carbamoyl]cyclohex-3-ene-1-carboxylic acid

CAS 438537-98-5C₂₄H₂₇NO₅S

6-({[3-(Methoxycarbonyl)-4-(4-methylphenyl)-2-thienyl]amino}carbonyl)-3-cyclohexene-1-carboxylic acid chemical structure, C21H21NO5S, CAS 515150-03-5

6-({[3-(Methoxycarbonyl)-4-(4-methylphenyl)-2-thienyl]amino}carbonyl)-3-cyclohexene-1-carboxylic acid

CAS 515150-03-5C₂₁H₂₁NO₅S

6-({[4-(3,4-Dimethylphenyl)-3-(ethoxycarbonyl)thien-2-yl]amino}carbonyl)cyclohex-3-ene-1-carboxylic acid chemical structure, C23H25NO5S, CAS 495383-27-2

6-({[4-(3,4-Dimethylphenyl)-3-(ethoxycarbonyl)thien-2-yl]amino}carbonyl)cyclohex-3-ene-1-carboxylic acid

CAS 495383-27-2C₂₃H₂₅NO₅S

6-[[3-Carbamoyl-4-(4-chlorophenyl)thiophen-2-yl]carbamoyl]cyclohex-3-ene-1-carboxylic acid chemical structure, C19H17ClN2O4S, CAS 495396-14-0

6-[[3-Carbamoyl-4-(4-chlorophenyl)thiophen-2-yl]carbamoyl]cyclohex-3-ene-1-carboxylic acid

CAS 495396-14-0C₁₉H₁₇ClN₂O₄S

6-({3-Carbamoyl-5-methyl-4-[4-(propan-2-yl)phenyl]thiophen-2-yl}carbamoyl)-3,4-dimethylcyclohex-3-ene-1-carboxylic acid chemical structure, C25H30N2O4S, CAS 438196-43-1

6-({3-Carbamoyl-5-methyl-4-[4-(propan-2-yl)phenyl]thiophen-2-yl}carbamoyl)-3,4-dimethylcyclohex-3-ene-1-carboxylic acid

CAS 438196-43-1C₂₅H₃₀N₂O₄S

6-[[3-Ethoxycarbonyl-4-(3-methylphenyl)thiophen-2-yl]carbamoyl]cyclohex-3-ene-1-carboxylic acid chemical structure, C22H23NO5S, CAS 495386-94-2

6-[[3-Ethoxycarbonyl-4-(3-methylphenyl)thiophen-2-yl]carbamoyl]cyclohex-3-ene-1-carboxylic acid

CAS 495386-94-2C₂₂H₂₃NO₅S

6-{[4-(4-tert-Butylphenyl)-3-carbamoyl-5-methylthiophen-2-yl]carbamoyl}cyclohex-3-ene-1-carboxylic acid chemical structure, C24H28N2O4S, CAS 724758-31-0

6-{[4-(4-tert-Butylphenyl)-3-carbamoyl-5-methylthiophen-2-yl]carbamoyl}cyclohex-3-ene-1-carboxylic acid

CAS 724758-31-0C₂₄H₂₈N₂O₄S

6-{[4-(3,4-Dimethylphenyl)-3-(methoxycarbonyl)-5-methylthiophen-2-yl]carbamoyl}-3,4-dimethylcyclohex-3-ene-1-carboxylic acid chemical structure, C25H29NO5S, CAS 888115-65-9

6-{[4-(3,4-Dimethylphenyl)-3-(methoxycarbonyl)-5-methylthiophen-2-yl]carbamoyl}-3,4-dimethylcyclohex-3-ene-1-carboxylic acid

CAS 888115-65-9C₂₅H₂₉NO₅S

6-{[4-(4-Fluorophenyl)-3-(methoxycarbonyl)-5-methylthiophen-2-yl]carbamoyl}-3,4-dimethylcyclohex-3-ene-1-carboxylic acid chemical structure, C23H24FNO5S, CAS 888115-72-8

6-{[4-(4-Fluorophenyl)-3-(methoxycarbonyl)-5-methylthiophen-2-yl]carbamoyl}-3,4-dimethylcyclohex-3-ene-1-carboxylic acid

CAS 888115-72-8C₂₃H₂₄FNO₅S

6-{[4-(4-tert-Butylphenyl)-3-(methoxycarbonyl)thiophen-2-yl]carbamoyl}-3,4-dimethylcyclohex-3-ene-1-carboxylic acid chemical structure, C26H31NO5S, CAS 880059-08-5

6-{[4-(4-tert-Butylphenyl)-3-(methoxycarbonyl)thiophen-2-yl]carbamoyl}-3,4-dimethylcyclohex-3-ene-1-carboxylic acid

CAS 880059-08-5C₂₆H₃₁NO₅S