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Murcko scaffold

1-(2-Phenylethyl)pyrrolidin-2-one scaffold

61 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
14
Chemicals
61
With full pages
9
Scaffold SMILES

O=C1CCCN1CCc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(2-Phenylethyl)pyrrolidin-2-one page
Murcko scaffold O=C1CCCN1CCc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 61 chemicals

3-Pyrrolidinecarboxylic acid, 5-oxo-1-(2-phenylethyl)- chemical structure, C13H15NO3, CAS 30380-70-2
3-Pyrrolidinecarboxylic acid, 5-oxo-1-(2-phenylethyl)-
CAS 30380-70-2C13H15NO3
4-(Hydroxymethyl)-1-(2-phenylethyl)pyrrolidin-2-one chemical structure, C13H17NO2, CAS 904237-82-7
4-(Hydroxymethyl)-1-(2-phenylethyl)pyrrolidin-2-one
CAS 904237-82-7C13H17NO2
1-(2-Phenylethyl)pyrrolidin-2-one chemical structure, C12H15NO, CAS 10135-23-6
1-(2-Phenylethyl)pyrrolidin-2-one
CAS 10135-23-6C12H15NO
1-[2-(3,4-Dimethoxyphenyl)ethyl]-5-oxopyrrolidine-3-carboxylic acid chemical structure, C15H19NO5, CAS 85263-80-5
1-[2-(3,4-Dimethoxyphenyl)ethyl]-5-oxopyrrolidine-3-carboxylic acid
CAS 85263-80-5C15H19NO5
1-(4-Chlorophenethyl)-5-oxopyrrolidine-3-carboxylic acid chemical structure, C13H14ClNO3, CAS 368870-06-8
1-(4-Chlorophenethyl)-5-oxopyrrolidine-3-carboxylic acid
CAS 368870-06-8C13H14ClNO3
1-[2-(4-Methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carboxylic acid chemical structure, C14H17NO4, CAS 85263-81-6
1-[2-(4-Methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carboxylic acid
CAS 85263-81-6C14H17NO4
Oxoprolintane chemical structure, C15H21NO, CAS 35259-27-9
Oxoprolintane
CAS 35259-27-9C15H21NO
1-[2-(4-Fluorophenyl)ethyl]-5-oxopyrrolidine-3-carboxylic acid chemical structure, C13H14FNO3, CAS 842971-84-0
1-[2-(4-Fluorophenyl)ethyl]-5-oxopyrrolidine-3-carboxylic acid
CAS 842971-84-0C13H14FNO3
1-[2-(4-Methylphenyl)ethyl]-5-oxopyrrolidine-3-carboxylic acid chemical structure, C14H17NO3, CAS 899710-15-7
1-[2-(4-Methylphenyl)ethyl]-5-oxopyrrolidine-3-carboxylic acid
CAS 899710-15-7C14H17NO3
1-[2-(3,4-Diethoxyphenyl)ethyl]-5-oxo-3-pyrrolidinecarboxylic acid chemical structure, C17H23NO5, CAS 881040-72-8
1-[2-(3,4-Diethoxyphenyl)ethyl]-5-oxo-3-pyrrolidinecarboxylic acid
CAS 881040-72-8C17H23NO5
1-[2-(4-Hydroxyphenyl)ethyl]-5-oxopyrrolidine-3-carboxylic acid chemical structure, C13H15NO4, CAS 855496-61-6
1-[2-(4-Hydroxyphenyl)ethyl]-5-oxopyrrolidine-3-carboxylic acid
CAS 855496-61-6C13H15NO4
Methyl N-({1-[2-(4-fluorophenyl)ethyl]-5-oxopyrrolidin-3-yl}carbonyl)glycinate chemical structure, C16H19FN2O4, CAS 887678-09-3
Methyl N-({1-[2-(4-fluorophenyl)ethyl]-5-oxopyrrolidin-3-yl}carbonyl)glycinate
CAS 887678-09-3C16H19FN2O4
2-Pyrrolidinone, 5-hydroxy-1-[2-(4-methoxyphenyl)ethyl]- chemical structure, C13H17NO3, CAS 648435-11-4
2-Pyrrolidinone, 5-hydroxy-1-[2-(4-methoxyphenyl)ethyl]-
CAS 648435-11-4C13H17NO3
2-Pyrrolidinone, 5-ethoxy-1-[2-(4-methoxyphenyl)ethyl]- chemical structure, C15H21NO3, CAS 648435-18-1
2-Pyrrolidinone, 5-ethoxy-1-[2-(4-methoxyphenyl)ethyl]-
CAS 648435-18-1C15H21NO3
3-Pyrrolidineacetamide, N-hydroxy-2-oxo-1-(2-phenylethyl)- chemical structure, C14H18N2O3, CAS 798543-06-3
3-Pyrrolidineacetamide, N-hydroxy-2-oxo-1-(2-phenylethyl)-
CAS 798543-06-3C14H18N2O3
2-Pyrrolidinone, 1-(2-hydroxy-2-phenylethyl)- chemical structure, C12H15NO2, CAS 22081-44-3
2-Pyrrolidinone, 1-(2-hydroxy-2-phenylethyl)-
CAS 22081-44-3C12H15NO2
2-Pyrrolidinone, 1-[2-(3,4-dimethoxyphenyl)ethyl]- chemical structure, C14H19NO3, CAS 55716-88-6
2-Pyrrolidinone, 1-[2-(3,4-dimethoxyphenyl)ethyl]-
CAS 55716-88-6C14H19NO3
1-(2-Amino-2-phenylethyl)pyrrolidin-2-one chemical structure, C12H16N2O, CAS 43003-24-3
1-(2-Amino-2-phenylethyl)pyrrolidin-2-one
CAS 43003-24-3C12H16N2O
5-Oxo-1-(2-phenylethyl)pyrrolidine-3-carboxamide chemical structure, C13H16N2O2, CAS 92108-39-9
5-Oxo-1-(2-phenylethyl)pyrrolidine-3-carboxamide
CAS 92108-39-9C13H16N2O2
1-[2-(4-Fluorophenyl)ethyl]-N-(2-methoxyethyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C16H21FN2O3, CAS 896925-09-0
1-[2-(4-Fluorophenyl)ethyl]-N-(2-methoxyethyl)-5-oxopyrrolidine-3-carboxamide
CAS 896925-09-0C16H21FN2O3
1-{2-Amino-2-[3-(trifluoromethyl)phenyl]ethyl}pyrrolidin-2-one chemical structure, C13H15F3N2O, CAS 953898-98-1
1-{2-Amino-2-[3-(trifluoromethyl)phenyl]ethyl}pyrrolidin-2-one
CAS 953898-98-1C13H15F3N2O
Methyl 5-oxo-1-(2-phenylethyl)pyrrolidine-3-carboxylate chemical structure, C14H17NO3, CAS 100718-54-5
Methyl 5-oxo-1-(2-phenylethyl)pyrrolidine-3-carboxylate
CAS 100718-54-5C14H17NO3
5-Oxo-1-(2-phenylpropyl)pyrrolidine-3-carboxylic acid chemical structure, C14H17NO3, CAS 928713-55-7
5-Oxo-1-(2-phenylpropyl)pyrrolidine-3-carboxylic acid
CAS 928713-55-7C14H17NO3
1-[2-(2-Methoxyphenyl)ethyl]-5-oxopyrrolidine-3-carboxylic acid chemical structure, C14H17NO4, CAS 407634-12-2
1-[2-(2-Methoxyphenyl)ethyl]-5-oxopyrrolidine-3-carboxylic acid
CAS 407634-12-2C14H17NO4