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Murcko scaffold

2',3'-Dihydro-1'H-spiro(cyclopropane-1,4'-isoquinoline)-1',3'-dione scaffold

10 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
14
Chemicals
10
With full pages
1
Scaffold SMILES

O=C1NC(=O)C2(CC2)c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2',3'-Dihydro-1'H-spiro(cyclopropane-1,4'-isoquinoline)-1',3'-dione page
Murcko scaffold O=C1NC(=O)C2(CC2)c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

2'-Methylspiro[cyclopropane-1,4'(1'H)-isoquinoline]-1',3'(2'H)-dione chemical structure, C12H11NO2, CAS 31267-06-8
2'-Methylspiro[cyclopropane-1,4'(1'H)-isoquinoline]-1',3'(2'H)-dione
CAS 31267-06-8C12H11NO2
2',3'-Dihydro-1'H-spiro(cyclopropane-1,4'-isoquinoline)-1',3'-dione chemical structure, C11H9NO2, CAS 31267-07-9
2',3'-Dihydro-1'H-spiro(cyclopropane-1,4'-isoquinoline)-1',3'-dione
CAS 31267-07-9C11H9NO2
2'-Methyl-7'-nitrospiro[cyclopropane-1,4'(1'H)-isoquinoline]-1',3'(2'H)-dione chemical structure, C12H10N2O4, CAS 1092795-10-2
2'-Methyl-7'-nitrospiro[cyclopropane-1,4'(1'H)-isoquinoline]-1',3'(2'H)-dione
CAS 1092795-10-2C12H10N2O4
7'-Amino-2'-ethyl-1'H-spiro[cyclopropane-1,4'-isoquinoline]-1',3'(2'H)-dione chemical structure, C13H14N2O2, CAS 1784401-32-6
7'-Amino-2'-ethyl-1'H-spiro[cyclopropane-1,4'-isoquinoline]-1',3'(2'H)-dione
CAS 1784401-32-6C13H14N2O2
6'-Bromo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-1',3'-dione chemical structure, C11H8BrNO2, CAS 2167621-83-0
6'-Bromo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-1',3'-dione
CAS 2167621-83-0C11H8BrNO2
7'-Bromo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-1',3'-dione chemical structure, C11H8BrNO2, CAS 2584878-75-9
7'-Bromo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-1',3'-dione
CAS 2584878-75-9C11H8BrNO2
6'-Bromo-5'-fluoro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-1',3'(2'H)-dione chemical structure, C11H7BrFNO2, CAS 2892253-10-8
6'-Bromo-5'-fluoro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-1',3'(2'H)-dione
CAS 2892253-10-8C11H7BrFNO2
6'-(Trifluoromethyl)-1'H-spiro[cyclopropane-1,4'-isoquinoline]-1',3'(2'H)-dione chemical structure, C12H8F3NO2, CAS 2892253-27-7
6'-(Trifluoromethyl)-1'H-spiro[cyclopropane-1,4'-isoquinoline]-1',3'(2'H)-dione
CAS 2892253-27-7C12H8F3NO2
Rel-(1R,2S)-6'-bromo-2-methyl-spiro[cyclopropane-1,4'-isoquinoline]-1',3'-dione chemical structure, C12H10BrNO2, CAS 2892253-25-5
Rel-(1R,2S)-6'-bromo-2-methyl-spiro[cyclopropane-1,4'-isoquinoline]-1',3'-dione
CAS 2892253-25-5C12H10BrNO2
5'-Fluoro-6'-(trifluoromethyl)-1'H-spiro[cyclopropane-1,4'-isoquinoline]-1',3'(2'H)-dione chemical structure, C12H7F4NO2, CAS 2892253-29-9
5'-Fluoro-6'-(trifluoromethyl)-1'H-spiro[cyclopropane-1,4'-isoquinoline]-1',3'(2'H)-dione
CAS 2892253-29-9C12H7F4NO2