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Murcko scaffold

2',3'-Dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-1'-one scaffold

27 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 13
Chemicals: 27
With full pages: 1

Scaffold SMILES

O=C1NCC2(CC2)c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 2',3'-Dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-1'-one page

Murcko scaffold O=C1NCC2(CC2)c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 27 of 27 chemicals

6'-Bromo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one chemical structure, C11H10BrNO, CAS 1396777-75-5

6'-Bromo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one

CAS 1396777-75-5C₁₁H₁₀BrNO

2',3'-Dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-1'-one chemical structure, C11H11NO, CAS 1782267-00-8

2',3'-Dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-1'-one

CAS 1782267-00-8C₁₁H₁₁NO

6'-Fluoro-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one chemical structure, C11H10FNO, CAS 1782267-06-4

6'-Fluoro-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one

CAS 1782267-06-4C₁₁H₁₀FNO

5'-Fluoro-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one chemical structure, C11H10FNO, CAS 1781879-71-7

5'-Fluoro-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one

CAS 1781879-71-7C₁₁H₁₀FNO

7'-Bromo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one chemical structure, C11H10BrNO, CAS 1781804-97-4

7'-Bromo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one

CAS 1781804-97-4C₁₁H₁₀BrNO

7'-Methoxy-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one chemical structure, C12H13NO2, CAS 1782801-22-2

7'-Methoxy-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one

CAS 1782801-22-2C₁₂H₁₃NO₂

7'-Amino-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one chemical structure, C11H12N2O, CAS 2568928-19-6

7'-Amino-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one

CAS 2568928-19-6C₁₁H₁₂N₂O

7'-Nitro-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one chemical structure, C11H10N2O3, CAS 2568928-18-5

7'-Nitro-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one

CAS 2568928-18-5C₁₁H₁₀N₂O₃

5'-Fluoro-6'-(trifluoromethyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one chemical structure, C12H9F4NO, CAS 2771023-02-8

5'-Fluoro-6'-(trifluoromethyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one

CAS 2771023-02-8C₁₂H₉F₄NO

rel-(1R,2S)-6'-Bromo-2,5'-difluoro-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one chemical structure, C11H8BrF2NO, CAS 2771023-40-4

rel-(1R,2S)-6'-Bromo-2,5'-difluoro-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one

CAS 2771023-40-4C₁₁H₈BrF₂NO

6'-Bromo-5'-fluoro-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one chemical structure, C11H9BrFNO, CAS 2771023-14-2

6'-Bromo-5'-fluoro-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one

CAS 2771023-14-2C₁₁H₉BrFNO

rel-(1R,2S)-6'-Bromo-2-(trifluoromethyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one chemical structure, C12H9BrF3NO, CAS 2771024-28-1

rel-(1R,2S)-6'-Bromo-2-(trifluoromethyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one

CAS 2771024-28-1C₁₂H₉BrF₃NO

6'-(Trifluoromethyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one chemical structure, C12H10F3NO, CAS 2771022-79-6

6'-(Trifluoromethyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one

CAS 2771022-79-6C₁₂H₁₀F₃NO

6'-Bromo-5'-chloro-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one chemical structure, C11H9BrClNO, CAS 2771024-20-3

6'-Bromo-5'-chloro-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one

CAS 2771024-20-3C₁₁H₉BrClNO

rel-(1R,2S)-6'-Bromo-2-fluoro-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one chemical structure, C11H9BrFNO, CAS 2771023-29-9

rel-(1R,2S)-6'-Bromo-2-fluoro-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one

CAS 2771023-29-9C₁₁H₉BrFNO

rel-(1R,2S)-2-Fluoro-6'-(trifluoromethyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one chemical structure, C12H9F4NO, CAS 2771023-49-3

rel-(1R,2S)-2-Fluoro-6'-(trifluoromethyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one

CAS 2771023-49-3C₁₂H₉F₄NO

6'-Bromo-2,2,5'-trifluoro-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one chemical structure, C11H7BrF3NO, CAS 2771023-97-1

6'-Bromo-2,2,5'-trifluoro-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one

CAS 2771023-97-1C₁₁H₇BrF₃NO

2-(6'-Bromo-2,2,5'-trifluoro-1'-oxo-1'H-spiro[cyclopropane-1,4'-isoquinolin]-2'(3'H)-yl)acetic acid chemical structure, C13H9BrF3NO3, CAS 2771023-99-3

2-(6'-Bromo-2,2,5'-trifluoro-1'-oxo-1'H-spiro[cyclopropane-1,4'-isoquinolin]-2'(3'H)-yl)acetic acid

CAS 2771023-99-3C₁₃H₉BrF₃NO₃

6-Bromo-1',1'-difluoro-spiro[2,3-dihydroisoquinoline-4,2'-cyclopropane]-1-one chemical structure, C11H8BrF2NO, CAS 2771025-18-2

6-Bromo-1',1'-difluoro-spiro[2,3-dihydroisoquinoline-4,2'-cyclopropane]-1-one

CAS 2771025-18-2C₁₁H₈BrF₂NO

5'-Bromo-7'-(chloromethyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one chemical structure, C12H11BrClNO, CAS 2788976-06-5

5'-Bromo-7'-(chloromethyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one

CAS 2788976-06-5C₁₂H₁₁BrClNO

Methyl 1'-oxo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-7'-carboxylate chemical structure, C13H13NO3, CAS 2788976-01-0

Methyl 1'-oxo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-7'-carboxylate

CAS 2788976-01-0C₁₃H₁₃NO₃

Methyl 5'-bromo-1'-oxo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-7'-carboxylate chemical structure, C13H12BrNO3, CAS 2788976-02-1

Methyl 5'-bromo-1'-oxo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-7'-carboxylate

CAS 2788976-02-1C₁₃H₁₂BrNO₃

rel-(1R,2R)-2-Fluoro-6'-(trifluoromethyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one chemical structure, C12H9F4NO, CAS 2771023-50-6

rel-(1R,2R)-2-Fluoro-6'-(trifluoromethyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one

CAS 2771023-50-6C₁₂H₉F₄NO

5'-Bromo-7'-(hydroxymethyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one chemical structure, C12H12BrNO2, CAS 2788976-05-4

5'-Bromo-7'-(hydroxymethyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-1'-one

CAS 2788976-05-4C₁₂H₁₂BrNO₂