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Murcko scaffold

Ring system with 3 rings and 16 atoms

52 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
52
With full pages
17
Scaffold SMILES

c1ccc(-n2ccc(-c3cccs3)n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-n2ccc(-c3cccs3)n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 52 chemicals

1-Phenyl-3-(thiophen-2-yl)-1H-pyrazole-4-carbaldehyde chemical structure, C14H10N2OS, CAS 210825-11-9
1-Phenyl-3-(thiophen-2-yl)-1H-pyrazole-4-carbaldehyde
CAS 210825-11-9C14H10N2OS
[1-Phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl]methanol chemical structure, C14H12N2OS, CAS 372190-27-7
[1-Phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl]methanol
CAS 372190-27-7C14H12N2OS
2-(4-Methylphenyl)-5-thiophen-2-ylpyrazole-3-carboxylic acid chemical structure, C15H12N2O2S, CAS 618382-78-8
2-(4-Methylphenyl)-5-thiophen-2-ylpyrazole-3-carboxylic acid
CAS 618382-78-8C15H12N2O2S
1-(4-Chlorophenyl)-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid chemical structure, C14H9ClN2O2S, CAS 618382-79-9
1-(4-Chlorophenyl)-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid
CAS 618382-79-9C14H9ClN2O2S
1-(4-Fluorophenyl)-3-(thiophen-2-yl)-1H-pyrazole-5-carboxylic acid chemical structure, C14H9FN2O2S, CAS 618382-80-2
1-(4-Fluorophenyl)-3-(thiophen-2-yl)-1H-pyrazole-5-carboxylic acid
CAS 618382-80-2C14H9FN2O2S
1-(4-Methoxyphenyl)-3-(thiophen-2-yl)-1H-pyrazole-5-carboxylic acid chemical structure, C15H12N2O3S, CAS 618382-81-3
1-(4-Methoxyphenyl)-3-(thiophen-2-yl)-1H-pyrazole-5-carboxylic acid
CAS 618382-81-3C15H12N2O3S
1-(2-Chlorophenyl)-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid chemical structure, C14H9ClN2O2S, CAS 618382-88-0
1-(2-Chlorophenyl)-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid
CAS 618382-88-0C14H9ClN2O2S
3-(Thiophen-2-yl)-1-M-tolyl-1H-pyrazole-5-carboxylic acid chemical structure, C15H12N2O2S, CAS 618382-84-6
3-(Thiophen-2-yl)-1-M-tolyl-1H-pyrazole-5-carboxylic acid
CAS 618382-84-6C15H12N2O2S
N-(3-Methylbutyl)-1-phenyl-3-(2-thienyl)-1H-pyrazole-5-carboxamide chemical structure, C19H21N3OS, CAS 955971-73-0
N-(3-Methylbutyl)-1-phenyl-3-(2-thienyl)-1H-pyrazole-5-carboxamide
CAS 955971-73-0C19H21N3OS
3-(1-Phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)acrylic acid chemical structure, C16H12N2O2S, CAS 302581-52-8
3-(1-Phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)acrylic acid
CAS 302581-52-8C16H12N2O2S
1-Phenyl-3-(thiophen-2-yl)-1H-pyrazole-4-carboxylic acid chemical structure, C14H10N2O2S, CAS 372107-08-9
1-Phenyl-3-(thiophen-2-yl)-1H-pyrazole-4-carboxylic acid
CAS 372107-08-9C14H10N2O2S
3-(5-Chlorothiophen-2-yl)-1-phenyl-1H-pyrazole-4-carboxylic acid chemical structure, C14H9ClN2O2S, CAS 882228-95-7
3-(5-Chlorothiophen-2-yl)-1-phenyl-1H-pyrazole-4-carboxylic acid
CAS 882228-95-7C14H9ClN2O2S
(Z)-2-Cyano-3-(1-phenyl-3-thiophen-2-ylpyrazol-4-yl)-N-prop-2-enylprop-2-enamide chemical structure, C20H16N4OS, CAS 313361-33-0
(Z)-2-Cyano-3-(1-phenyl-3-thiophen-2-ylpyrazol-4-yl)-N-prop-2-enylprop-2-enamide
CAS 313361-33-0C20H16N4OS
1-(3-Chlorophenyl)-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid chemical structure, C14H9ClN2O2S, CAS 618382-83-5
1-(3-Chlorophenyl)-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid
CAS 618382-83-5C14H9ClN2O2S
Agn-PC-0KC9NW chemical structure, C13H11N3S, CAS 5516-73-4
Agn-PC-0KC9NW
CAS 5516-73-4C13H11N3S
2-[[1-Phenyl-3-(2-thienyl)-1H-pyrazol-4-yl]methylene]hydrazinecarbothioamide chemical structure, C15H13N5S2, CAS 301234-93-5
2-[[1-Phenyl-3-(2-thienyl)-1H-pyrazol-4-yl]methylene]hydrazinecarbothioamide
CAS 301234-93-5C15H13N5S2
1H-Pyrazole-4-acetic acid, 1-phenyl-3-(2-thienyl)- chemical structure, C15H12N2O2S, CAS 88696-85-9
1H-Pyrazole-4-acetic acid, 1-phenyl-3-(2-thienyl)-
CAS 88696-85-9C15H12N2O2S
N-(2-Acetamidoethyl)-1-phenyl-3-(thiophen-2-yl)-1H-pyrazole-4-carboxamide chemical structure, C18H18N4O2S, CAS 686770-29-6
N-(2-Acetamidoethyl)-1-phenyl-3-(thiophen-2-yl)-1H-pyrazole-4-carboxamide
CAS 686770-29-6C18H18N4O2S
(2E)-3-[3-(5-Chlorothiophen-2-yl)-1-phenyl-1H-pyrazol-4-yl]prop-2-enoic acid chemical structure, C16H11ClN2O2S, CAS 956387-15-8
(2E)-3-[3-(5-Chlorothiophen-2-yl)-1-phenyl-1H-pyrazol-4-yl]prop-2-enoic acid
CAS 956387-15-8C16H11ClN2O2S
2-Cyano-N-(3-ethoxypropyl)-3-[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl]prop-2-enamide chemical structure, C22H22N4O2S, CAS 1007182-20-8
2-Cyano-N-(3-ethoxypropyl)-3-[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl]prop-2-enamide
CAS 1007182-20-8C22H22N4O2S
(2-Amino-2-oxoethyl) 2-phenyl-5-thiophen-2-ylpyrazole-3-carboxylate chemical structure, C16H13N3O3S, CAS 956505-20-7
(2-Amino-2-oxoethyl) 2-phenyl-5-thiophen-2-ylpyrazole-3-carboxylate
CAS 956505-20-7C16H13N3O3S
1-(4-Fluorophenyl)-3-(thiophen-2-yl)-1H-pyrazol-5-amine chemical structure, C13H10FN3S, CAS 956784-97-7
1-(4-Fluorophenyl)-3-(thiophen-2-yl)-1H-pyrazol-5-amine
CAS 956784-97-7C13H10FN3S
2-Phenyl-5-thiophen-2-yl-2H-pyrazole-3-carboxylic acid chemical structure, C14H10N2O2S, CAS 618382-77-7
2-Phenyl-5-thiophen-2-yl-2H-pyrazole-3-carboxylic acid
CAS 618382-77-7C14H10N2O2S
1-(2-Methylphenyl)-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid chemical structure, C15H12N2O2S, CAS 618382-85-7
1-(2-Methylphenyl)-3-(2-thienyl)-1H-pyrazole-5-carboxylic acid
CAS 618382-85-7C15H12N2O2S