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Murcko scaffold

Ring system with 3 rings and 16 atoms

78 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
78
With full pages
22
Scaffold SMILES

c1ccc(C2CC(c3cccs3)=NN2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(C2CC(c3cccs3)=NN2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 78 chemicals

1-[3-(4-Bromophenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone chemical structure, C15H13BrN2OS, CAS 326914-50-5
1-[3-(4-Bromophenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone
CAS 326914-50-5C15H13BrN2OS
4-[5-(4-Methoxy-phenyl)-3-thiophen-2-yl-4,5-dihydro-pyrazol-1-yl]-4-oxo-butyric acid chemical structure, C18H18N2O4S, CAS 332390-97-3
4-[5-(4-Methoxy-phenyl)-3-thiophen-2-yl-4,5-dihydro-pyrazol-1-yl]-4-oxo-butyric acid
CAS 332390-97-3C18H18N2O4S
4-[3-(4-Bromophenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-4-oxobutanoic acid chemical structure, C17H15BrN2O3S, CAS 361480-91-3
4-[3-(4-Bromophenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-4-oxobutanoic acid
CAS 361480-91-3C17H15BrN2O3S
1-(5-(4-Methoxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone chemical structure, C16H16N2O2S, CAS 152432-15-0
1-(5-(4-Methoxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone
CAS 152432-15-0C16H16N2O2S
5-(2-Fluorophenyl)-1-(methylsulfonyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole chemical structure, C14H13FN2O2S2, CAS 701224-74-0
5-(2-Fluorophenyl)-1-(methylsulfonyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole
CAS 701224-74-0C14H13FN2O2S2
5-(3,4-Dimethoxyphenyl)-1-(methylsulfonyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole chemical structure, C16H18N2O4S2, CAS 511237-78-8
5-(3,4-Dimethoxyphenyl)-1-(methylsulfonyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole
CAS 511237-78-8C16H18N2O4S2
1-[3-(3,4-Dimethoxyphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone chemical structure, C17H18N2O3S, CAS 152432-17-2
1-[3-(3,4-Dimethoxyphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone
CAS 152432-17-2C17H18N2O3S
2-Methylsulfonyl-3-phenyl-5-thiophen-2-yl-3,4-dihydropyrazole chemical structure, C14H14N2O2S2, CAS 701240-95-1
2-Methylsulfonyl-3-phenyl-5-thiophen-2-yl-3,4-dihydropyrazole
CAS 701240-95-1C14H14N2O2S2
5-(2,3-Dimethoxyphenyl)-1-(methylsulfonyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole chemical structure, C16H18N2O4S2, CAS 488138-18-7
5-(2,3-Dimethoxyphenyl)-1-(methylsulfonyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole
CAS 488138-18-7C16H18N2O4S2
5-(4-Methoxyphenyl)-1-propionyl-3-(2-thienyl)-4,5-dihydro-1H-pyrazole chemical structure, C17H18N2O2S, CAS 362491-49-4
5-(4-Methoxyphenyl)-1-propionyl-3-(2-thienyl)-4,5-dihydro-1H-pyrazole
CAS 362491-49-4C17H18N2O2S
1-[3-(3-Nitrophenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]propan-1-one chemical structure, C16H15N3O3S, CAS 708281-83-8
1-[3-(3-Nitrophenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]propan-1-one
CAS 708281-83-8C16H15N3O3S
3-(2-Methylphenyl)-2-methylsulfonyl-5-thiophen-2-yl-3,4-dihydropyrazole chemical structure, C15H16N2O2S2, CAS 710986-67-7
3-(2-Methylphenyl)-2-methylsulfonyl-5-thiophen-2-yl-3,4-dihydropyrazole
CAS 710986-67-7C15H16N2O2S2
1-[5-(2-Methylphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one chemical structure, C16H16N2OS, CAS 710986-70-2
1-[5-(2-Methylphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one
CAS 710986-70-2C16H16N2OS
5-(2-Chloro-6-fluorophenyl)-1-methanesulfonyl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole chemical structure, C14H12ClFN2O2S2, CAS 825599-59-5
5-(2-Chloro-6-fluorophenyl)-1-methanesulfonyl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole
CAS 825599-59-5C14H12ClFN2O2S2
3-(2-Ethoxyphenyl)-2-methylsulfonyl-5-thiophen-2-yl-3,4-dihydropyrazole chemical structure, C16H18N2O3S2, CAS 710986-73-5
3-(2-Ethoxyphenyl)-2-methylsulfonyl-5-thiophen-2-yl-3,4-dihydropyrazole
CAS 710986-73-5C16H18N2O3S2
1-[3-(2-Ethoxyphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone chemical structure, C17H18N2O2S, CAS 710986-76-8
1-[3-(2-Ethoxyphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone
CAS 710986-76-8C17H18N2O2S
1-[5-(2-Chloro-6-fluorophenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one chemical structure, C15H12ClFN2OS, CAS 825599-60-8
1-[5-(2-Chloro-6-fluorophenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one
CAS 825599-60-8C15H12ClFN2OS
Ethyl 2-(2-(1-acetyl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)phenoxy)acetate chemical structure, C19H20N2O4S, CAS 831179-00-1
Ethyl 2-(2-(1-acetyl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)phenoxy)acetate
CAS 831179-00-1C19H20N2O4S
3-(3-Methoxyphenyl)-2-methylsulfonyl-5-thiophen-2-yl-3,4-dihydropyrazole chemical structure, C15H16N2O3S2, CAS 831198-83-5
3-(3-Methoxyphenyl)-2-methylsulfonyl-5-thiophen-2-yl-3,4-dihydropyrazole
CAS 831198-83-5C15H16N2O3S2
1-(5-(2-Hydroxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone chemical structure, C15H14N2O2S, CAS 131557-39-6
1-(5-(2-Hydroxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone
CAS 131557-39-6C15H14N2O2S
4-[5-(3-Nitro-phenyl)-3-thiophen-2-yl-4,5-dihydro-pyrazol-1-yl]-4-oxo-butyric acid chemical structure, C17H15N3O5S, CAS 6128-55-8
4-[5-(3-Nitro-phenyl)-3-thiophen-2-yl-4,5-dihydro-pyrazol-1-yl]-4-oxo-butyric acid
CAS 6128-55-8C17H15N3O5S
4-[5-(3,4-Dimethoxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-oxobutanoic acid chemical structure, C19H20N2O5S, CAS 376616-25-0
4-[5-(3,4-Dimethoxyphenyl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-oxobutanoic acid
CAS 376616-25-0C19H20N2O5S
5-(4-Methoxyphenyl)-N-methyl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide chemical structure, C16H17N3OS2, CAS 362491-58-5
5-(4-Methoxyphenyl)-N-methyl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
CAS 362491-58-5C16H17N3OS2
4-Oxo-4-[5-phenyl-3-(2-thienyl)-4,5-dihydro-1H-pyrazol-1-yl]butanoic acid chemical structure, C17H16N2O3S, CAS 511237-79-9
4-Oxo-4-[5-phenyl-3-(2-thienyl)-4,5-dihydro-1H-pyrazol-1-yl]butanoic acid
CAS 511237-79-9C17H16N2O3S