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Murcko scaffold

1H-Pyrazole, 4,5-dihydro-3-phenyl-5-(thienyl)- scaffold

61 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
61
With full pages
33
Scaffold SMILES

c1ccc(C2=NNC(c3cccs3)C2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1H-Pyrazole, 4,5-dihydro-3-phenyl-5-(thienyl)- page
Murcko scaffold c1ccc(C2=NNC(c3cccs3)C2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 61 chemicals

4-[3-(4-Bromophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-oxobutanoic acid chemical structure, C17H15BrN2O3S, CAS 361175-11-3
4-[3-(4-Bromophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-oxobutanoic acid
CAS 361175-11-3C17H15BrN2O3S
4-(3-(4-Methoxyphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid chemical structure, C18H18N2O4S, CAS 361175-12-4
4-(3-(4-Methoxyphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid
CAS 361175-12-4C18H18N2O4S
4-Bromo-2-(5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenol chemical structure, C13H11BrN2OS, CAS 610277-76-4
4-Bromo-2-(5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenol
CAS 610277-76-4C13H11BrN2OS
5-(4-Chlorophenyl)-2-methylsulfonyl-3-thiophen-2-yl-3,4-dihydropyrazole chemical structure, C14H13ClN2O2S2, CAS 497867-37-5
5-(4-Chlorophenyl)-2-methylsulfonyl-3-thiophen-2-yl-3,4-dihydropyrazole
CAS 497867-37-5C14H13ClN2O2S2
4-[5-(3,4-Dimethoxyphenyl)-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-4-oxobutanoic acid chemical structure, C19H20N2O5S, CAS 701229-77-8
4-[5-(3,4-Dimethoxyphenyl)-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-4-oxobutanoic acid
CAS 701229-77-8C19H20N2O5S
3-(3-Methoxyphenyl)-1-(methylsulfonyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole chemical structure, C15H16N2O3S2, CAS 701230-52-6
3-(3-Methoxyphenyl)-1-(methylsulfonyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole
CAS 701230-52-6C15H16N2O3S2
1-(3-(3,4-Dimethoxyphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethan-1-one chemical structure, C17H18N2O3S, CAS 702650-31-5
1-(3-(3,4-Dimethoxyphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethan-1-one
CAS 702650-31-5C17H18N2O3S
N-[3-(2-Acetyl-3-thiophen-2-yl-3,4-dihydropyrazol-5-yl)phenyl]ethanesulfonamide chemical structure, C17H19N3O3S2, CAS 710986-51-9
N-[3-(2-Acetyl-3-thiophen-2-yl-3,4-dihydropyrazol-5-yl)phenyl]ethanesulfonamide
CAS 710986-51-9C17H19N3O3S2
N-{3-[1-Acetyl-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}methanesulfonamide chemical structure, C16H17N3O3S2, CAS 838811-19-1
N-{3-[1-Acetyl-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}methanesulfonamide
CAS 838811-19-1C16H17N3O3S2
N-(3-(1-(Methylsulfonyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)methanesulfonamide chemical structure, C15H17N3O4S3, CAS 838844-71-6
N-(3-(1-(Methylsulfonyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)methanesulfonamide
CAS 838844-71-6C15H17N3O4S3
N-[3-(2-Propanoyl-3-thiophen-2-yl-3,4-dihydropyrazol-5-yl)phenyl]methanesulfonamide chemical structure, C17H19N3O3S2, CAS 851780-59-1
N-[3-(2-Propanoyl-3-thiophen-2-yl-3,4-dihydropyrazol-5-yl)phenyl]methanesulfonamide
CAS 851780-59-1C17H19N3O3S2
3-(4-Methoxyphenyl)-1-(methylsulfonyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole chemical structure, C15H16N2O3S2, CAS 497942-84-4
3-(4-Methoxyphenyl)-1-(methylsulfonyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole
CAS 497942-84-4C15H16N2O3S2
5-(3-(3,4-Dimethoxyphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-5-oxopentanoic acid chemical structure, C20H22N2O5S, CAS 799258-16-5
5-(3-(3,4-Dimethoxyphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-5-oxopentanoic acid
CAS 799258-16-5C20H22N2O5S
N-(4-(1-(Methylsulfonyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)ethanesulfonamide chemical structure, C16H19N3O4S3, CAS 797775-15-6
N-(4-(1-(Methylsulfonyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)ethanesulfonamide
CAS 797775-15-6C16H19N3O4S3
2-((2-Hydroxyethyl)amino)-1-(5-(thiophen-2-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone chemical structure, C18H21N3O2S, CAS 868213-35-8
2-((2-Hydroxyethyl)amino)-1-(5-(thiophen-2-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone
CAS 868213-35-8C18H21N3O2S
1-[3-(2-Hydroxy-phenyl)-5-thiophen-2-yl-4,5-dihydro-pyrazol-1-yl]-ethanone chemical structure, C15H14N2O2S, CAS 149054-50-2
1-[3-(2-Hydroxy-phenyl)-5-thiophen-2-yl-4,5-dihydro-pyrazol-1-yl]-ethanone
CAS 149054-50-2C15H14N2O2S
1-[5-(3-Hydroxyphenyl)-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone chemical structure, C15H14N2O2S, CAS 871319-01-6
1-[5-(3-Hydroxyphenyl)-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone
CAS 871319-01-6C15H14N2O2S
3-(4-Bromophenyl)-1-(methylsulfonyl)-5-(2-thienyl)-4,5-dihydro-1H-pyrazole chemical structure, C14H13BrN2O2S2, CAS 497232-12-9
3-(4-Bromophenyl)-1-(methylsulfonyl)-5-(2-thienyl)-4,5-dihydro-1H-pyrazole
CAS 497232-12-9C14H13BrN2O2S2
4-Chloro-2-(5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenol chemical structure, C13H11ClN2OS, CAS 610277-75-3
4-Chloro-2-(5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenol
CAS 610277-75-3C13H11ClN2OS
N-(3-(1-Pivaloyl-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)methanesulfonamide chemical structure, C19H23N3O3S2, CAS 851780-58-0
N-(3-(1-Pivaloyl-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)methanesulfonamide
CAS 851780-58-0C19H23N3O3S2
4-Oxo-4-(5-phenyl-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl)butanoic acid chemical structure, C17H16N2O3S, CAS 385400-88-4
4-Oxo-4-(5-phenyl-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl)butanoic acid
CAS 385400-88-4C17H16N2O3S
5-Oxo-5-(5-phenyl-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl)pentanoic acid chemical structure, C18H18N2O3S, CAS 724437-45-0
5-Oxo-5-(5-phenyl-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl)pentanoic acid
CAS 724437-45-0C18H18N2O3S
4-Fluoro-2-(5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenol chemical structure, C13H11FN2OS, CAS 610277-74-2
4-Fluoro-2-(5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenol
CAS 610277-74-2C13H11FN2OS
1-[5-(3-Methoxyphenyl)-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone chemical structure, C16H16N2O2S, CAS 836639-48-6
1-[5-(3-Methoxyphenyl)-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl]ethanone
CAS 836639-48-6C16H16N2O2S