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Murcko scaffold

Alpha-Methylene butyrolactone scaffold

127 chemicals on CompoundList share this ring system.

Rings
1
Scaffold atoms
7
Chemicals
127
With full pages
17
Scaffold SMILES

C=C1CCOC1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks. This is a very common single ring, so the list below is broad.

Substructure search with this scaffoldOpen the alpha-Methylene butyrolactone page
Murcko scaffold C=C1CCOC1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 127 chemicals

(E)-2-(2-(Hydroxymethyl)-4-(3-isobutyl-5-methylhexylidene)-5-oxo-tetrahydrofuran-2-yl)ethyl pivalate chemical structure, C22H38O5, CAS 388621-67-8
(E)-2-(2-(Hydroxymethyl)-4-(3-isobutyl-5-methylhexylidene)-5-oxo-tetrahydrofuran-2-yl)ethyl pivalate
CAS 388621-67-8C22H38O5
RefChem:1049889 chemical structure, C14H22O4, CAS 191282-48-1
RefChem:1049889
CAS 191282-48-1C14H22O4
Acetic acid 2-hydroxymethyl-4-octadec-9-enylidene-5-oxo-tetrahydro-furan-2-ylmethyl ester chemical structure, C26H44O5, CAS 172926-98-6
Acetic acid 2-hydroxymethyl-4-octadec-9-enylidene-5-oxo-tetrahydro-furan-2-ylmethyl ester
CAS 172926-98-6C26H44O5
(4R)-3-Ethylidene-4-(2-oxoethyl)tetrahydrofuran-2-one chemical structure, C8H10O3, CAS 144128-26-7
(4R)-3-Ethylidene-4-(2-oxoethyl)tetrahydrofuran-2-one
CAS 144128-26-7C8H10O3
Butyrolactone 3 chemical structure, C9H12O4, CAS 778649-18-6
Butyrolactone 3
CAS 778649-18-6C9H12O4
(4R)-Dihydro-4-hydroxy-3-methylene-2(3H)-furanone chemical structure, C5H6O3, CAS 95529-89-8
(4R)-Dihydro-4-hydroxy-3-methylene-2(3H)-furanone
CAS 95529-89-8C5H6O3
Litseakolide F chemical structure, C16H28O4, CAS 386705-29-9
Litseakolide F
CAS 386705-29-9C16H28O4
Litseakolide G chemical structure, C16H28O4, CAS 386705-30-2
Litseakolide G
CAS 386705-30-2C16H28O4
Litseakolide D chemical structure, C16H28O4, CAS 386705-27-7
Litseakolide D
CAS 386705-27-7C16H28O4
2(3H)-Furanone, dihydro-3-methylene-5-pentyl- chemical structure, C10H16O2, CAS 83650-09-3
2(3H)-Furanone, dihydro-3-methylene-5-pentyl-
CAS 83650-09-3C10H16O2
5-Ethyl-3-methylene-dihydro-furan-2-one chemical structure, C7H10O2, CAS 82112-60-5
5-Ethyl-3-methylene-dihydro-furan-2-one
CAS 82112-60-5C7H10O2
2(3H)-Furanone, dihydro-3-methylene-5-propyl- chemical structure, C8H12O2, CAS 58557-30-5
2(3H)-Furanone, dihydro-3-methylene-5-propyl-
CAS 58557-30-5C8H12O2
4-Methyl-3-methylenedihydrofuran-2(3H)-one chemical structure, C6H8O2, CAS 86220-10-2
4-Methyl-3-methylenedihydrofuran-2(3H)-one
CAS 86220-10-2C6H8O2
2(3H)-Furanone, 5-hexyldihydro-3-methylene- chemical structure, C11H18O2, CAS 26798-41-4
2(3H)-Furanone, 5-hexyldihydro-3-methylene-
CAS 26798-41-4C11H18O2
[(3S)-4-Methylidene-5-oxooxolan-3-yl] acetate chemical structure, C7H8O4, CAS 189351-45-9
[(3S)-4-Methylidene-5-oxooxolan-3-yl] acetate
CAS 189351-45-9C7H8O4
2(3H)-Furanone, dihydro-4,4-dimethyl-3-methylene- chemical structure, C7H10O2, CAS 135102-85-1
2(3H)-Furanone, dihydro-4,4-dimethyl-3-methylene-
CAS 135102-85-1C7H10O2
(3E)-3-(1-Chloroethylidene)-4-ethenyloxolan-2-one chemical structure, C8H9ClO2
(3E)-3-(1-Chloroethylidene)-4-ethenyloxolan-2-one
C8H9ClO2
(5S)-3-Methylidene-5-[(1S,2S,3R,4R)-1,2,3,4,5-pentahydroxypentyl]oxolan-2-one chemical structure, C10H16O7, CAS 289697-66-1
(5S)-3-Methylidene-5-[(1S,2S,3R,4R)-1,2,3,4,5-pentahydroxypentyl]oxolan-2-one
CAS 289697-66-1C10H16O7
Acetoxyanthecotulide chemical structure, C17H22O5, CAS 882677-15-8
Acetoxyanthecotulide
CAS 882677-15-8C17H22O5
Lincomolide B chemical structure, C17H26O3, CAS 403602-61-9
Lincomolide B
CAS 403602-61-9C17H26O3
2(3H)-Furanone, dihydro-4-methyl-3-methylene-, (R)- chemical structure, C6H8O2, CAS 62322-50-3
2(3H)-Furanone, dihydro-4-methyl-3-methylene-, (R)-
CAS 62322-50-3C6H8O2
Pycnolide chemical structure, C20H28O6, CAS 55306-05-3
Pycnolide
CAS 55306-05-3C20H28O6
2,2-Dimethyl-4-methylidene-5-oxooxolane-3-carboxylic acid chemical structure, C8H10O4, CAS 58785-72-1
2,2-Dimethyl-4-methylidene-5-oxooxolane-3-carboxylic acid
CAS 58785-72-1C8H10O4
3-Furancarboxylic acid, 2,2-diethyltetrahydro-4-methylene-5-oxo- chemical structure, C10H14O4, CAS 58785-71-0
3-Furancarboxylic acid, 2,2-diethyltetrahydro-4-methylene-5-oxo-
CAS 58785-71-0C10H14O4