Murcko scaffold
Alpha-Methylene butyrolactone scaffold
127 chemicals on CompoundList share this ring system.
- Rings
- 1
- Scaffold atoms
- 7
- Chemicals
- 127
- With full pages
- 17
Scaffold SMILES
C=C1CCOC1=O
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks. This is a very common single ring, so the list below is broad.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 127 chemicals
(+)-Protolichesteric acid
C19H32O4
alpha-Methylene butyrolactone
CAS 547-65-9C5H6O2
gamma-Methyl-alpha-methylene-gamma-butyrolactone
CAS 62873-16-9C6H8O2
Methylenolactocin
CAS 112923-53-2C11H16O4
Tulipalin B
CAS 38965-80-9C5H6O3
((2S,3S)-2-Methyl-4-methylidene-5-oxo-oxolan-3-yl) acetate
CAS 73738-74-6C8H10O4
(2-Ethyl-4-methylidene-5-oxo-oxolan-3-yl) acetate
CAS 76299-61-1C9H12O4
2(3H)-Furanone, 4-(acetyloxy)dihydro-3-methylene-5-(1-methylethyl)-
CAS 76299-62-2C10H14O4
(4-Methylidene-5-oxo-2-pentyloxolan-3-yl) acetate
CAS 76299-63-3C12H18O4
((2R,3S)-2-Methyl-4-methylidene-5-oxooxolan-3-yl) acetate
CAS 73738-75-7C8H10O4
2(3H)-Furanone, 4-(acetyloxy)dihydro-3-methylene-
CAS 73738-80-4C7H8O4
2(3H)-Furanone, dihydro-5-(1-methylethyl)-3-(1-methylethylidene)-
CAS 62687-41-6C10H16O2
Murolic acid
CAS 70579-58-7C21H36O5
Protoconstipatic acid
CAS 73036-29-0C21H36O5
4-Methylidene-5-oxo-2-tridecyloxolane-3-carboxylic acid
CAS 1448-96-0C19H32O4
3-Furoic acid, tetrahydro-4-methylene-5-oxo-
CAS 93913-58-7C6H6O4
Diethyl 4-methylidene-5-oxooxolane-3,3-dicarboxylate
CAS 56643-56-2C11H14O6
2(3H)-Furanone, dihydro-3-[(methylamino)methylene]-, (3E)-
CAS 168417-24-1C6H9NO2
2(3H)-Furanone, 3-[(dimethylamino)methylene]-5-hexyldihydro-
CAS 62527-58-6C13H23NO2
(2-Oxooxolan-3-ylidene)methyl methanesulfonate
CAS 113982-63-1C6H8O5S
AG-G-81985
CAS 71817-25-9C11H14O6
2-(4,4-Dimethyl-2-oxooxolan-3-ylidene)propanedinitrile
CAS 82698-94-0C9H8N2O2
Methyl 2-cyano-2-(4,4-dimethyl-2-oxo-oxolan-3-ylidene)acetate
CAS 82698-90-6C10H11NO4
Dimethyl 2-(4-ethyl-4-methyl-2-oxooxolan-3-ylidene)propanedioate
CAS 82698-88-2C12H16O6
- 4,4,5,5-Tetramethyl-3-methylideneoxolan-2-one69604-12-2C9H14O2
- Protolichesterinic acid493-46-9C19H32O4
- Plakolide A654645-17-7C18H28O2
- (3E)-3-Ethylidenedihydrofuran-2(3H)-one43142-58-1C6H8O2
- 3-(((Trimethylsilyl)oxy)methylene)dihydro-2(3H)-furanone76881-13-5C8H14O3Si
- Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic acid218137-86-1C14H22O4
- Litseakolide E386705-28-8C16H28O4
- (±)-Tulipaline B (compound 6)51348-66-4C5H6O3
- (3E)-3-Propylidene-tetrahydro-furan-2-one52216-90-7C7H10O2
- (5S)-5-(Hydroxymethyl)-3-methylideneoxolan-2-oneC6H8O3
- (3E)-3-(2-Methylpropylidene)oxolan-2-one5407-54-5C8H12O2
- (3E)-3-(Methoxymethylidene)oxolan-2-one28664-79-1C6H8O3
- 3-[1-Methylamino-meth-(E)-ylidene]-dihydro-furan-2-oneC6H9NO2
- [(E)-(5-Methyl-2-oxooxolan-3-ylidene)methyl]urea53761-30-1C7H10N2O3
- [(E)-(2-Oxo-5-propyloxolan-3-ylidene)methyl]urea53761-34-5C9H14N2O3
- [(E)-(5-Ethyl-2-oxooxolan-3-ylidene)methyl]urea53761-33-4C8H12N2O3
- 2(3H)-Furanone, 3-[(dimethylamino)methylene]dihydro-, (3E)-202596-45-0C7H11NO2
- (2E)-2-(4,4-Dimethyl-2-oxooxolan-3-ylidene)acetonitrile86453-70-5C8H9NO2
- Methyl (2Z)-2-(4,4-dimethyl-2-oxooxolan-3-ylidene)-3-oxobutanoate82698-85-9C11H14O5
- Mayolide A114728-06-2C20H30O4
- Nephrosterinic acid570-13-8C17H28O4
- (2S,3R)-4-Methylidene-2-octyl-5-oxooxolane-3-carboxylic acid1234694-22-4C14H22O4
- Majorynolide126622-45-5C17H26O3
- Majorenolide126622-46-6C17H28O3