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Murcko scaffold

Alpha-Methylene butyrolactone scaffold

127 chemicals on CompoundList share this ring system.

Rings
1
Scaffold atoms
7
Chemicals
127
With full pages
17
Scaffold SMILES

C=C1CCOC1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks. This is a very common single ring, so the list below is broad.

Substructure search with this scaffoldOpen the alpha-Methylene butyrolactone page
Murcko scaffold C=C1CCOC1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 97 to 127 of 127 chemicals

3-Ethylidene-5-(prop-1-en-1-yl)oxolan-2-one chemical structure, C9H12O2, CAS 61097-39-0
3-Ethylidene-5-(prop-1-en-1-yl)oxolan-2-one
CAS 61097-39-0C9H12O2
3-[(Butylsulfanyl)methylidene]oxolan-2-one chemical structure, C9H14O2S, CAS 62527-61-1
3-[(Butylsulfanyl)methylidene]oxolan-2-one
CAS 62527-61-1C9H14O2S
3-Heptylidene-5-methyloxolan-2-one chemical structure, C12H20O2, CAS 132209-86-0
3-Heptylidene-5-methyloxolan-2-one
CAS 132209-86-0C12H20O2
Ethyl hydroxy(2-oxooxolan-3-ylidene)acetate chemical structure, C8H10O5, CAS 110977-73-6
Ethyl hydroxy(2-oxooxolan-3-ylidene)acetate
CAS 110977-73-6C8H10O5
5-Ethyl-3-ethylideneoxolan-2-one chemical structure, C8H12O2, CAS 62668-22-8
5-Ethyl-3-ethylideneoxolan-2-one
CAS 62668-22-8C8H12O2
5-Methyl-3-pentylideneoxolan-2-one chemical structure, C10H16O2, CAS 62527-69-9
5-Methyl-3-pentylideneoxolan-2-one
CAS 62527-69-9C10H16O2
3-(2,2,3,3,4,4,4-Heptafluorobutylidene)oxolan-2-one chemical structure, C8H5F7O2, CAS 89608-45-7
3-(2,2,3,3,4,4,4-Heptafluorobutylidene)oxolan-2-one
CAS 89608-45-7C8H5F7O2
3-[Amino(methylamino)methylidene]-5-ethyloxolan-2-one chemical structure, C8H14N2O2, CAS 89810-30-0
3-[Amino(methylamino)methylidene]-5-ethyloxolan-2-one
CAS 89810-30-0C8H14N2O2
3-Methylidene-5-(prop-1-en-1-yl)oxolan-2-one chemical structure, C8H10O2, CAS 98061-43-9
3-Methylidene-5-(prop-1-en-1-yl)oxolan-2-one
CAS 98061-43-9C8H10O2
5-(Dodec-11-EN-1-yl)-3-methylideneoxolan-2-one chemical structure, C17H28O2, CAS 98061-44-0
5-(Dodec-11-EN-1-yl)-3-methylideneoxolan-2-one
CAS 98061-44-0C17H28O2
3-(Ethoxymethylidene)oxolan-2-one chemical structure, C7H10O3
3-(Ethoxymethylidene)oxolan-2-one
C7H10O3
3-(But-3-en-1-ylidene)oxolan-2-one chemical structure, C8H10O2, CAS 118891-10-4
3-(But-3-en-1-ylidene)oxolan-2-one
CAS 118891-10-4C8H10O2
3-(1-Chloroethylidene)-4-ethenyloxolan-2-one chemical structure, C8H9ClO2, CAS 154953-78-3
3-(1-Chloroethylidene)-4-ethenyloxolan-2-one
CAS 154953-78-3C8H9ClO2
5-Hexyl-3-pentylideneoxolan-2-one chemical structure, C15H26O2, CAS 62527-70-2
5-Hexyl-3-pentylideneoxolan-2-one
CAS 62527-70-2C15H26O2
3-Ethylidene-5-hexyloxolan-2-one chemical structure, C12H20O2, CAS 62527-66-6
3-Ethylidene-5-hexyloxolan-2-one
CAS 62527-66-6C12H20O2
3-[(Butylsulfanyl)methylidene]-5-hexyloxolan-2-one chemical structure, C15H26O2S, CAS 62527-63-3
3-[(Butylsulfanyl)methylidene]-5-hexyloxolan-2-one
CAS 62527-63-3C15H26O2S
3-[(Butylsulfanyl)methylidene]-5-methyloxolan-2-one chemical structure, C10H16O2S, CAS 62527-62-2
3-[(Butylsulfanyl)methylidene]-5-methyloxolan-2-one
CAS 62527-62-2C10H16O2S
5-Hexyl-3-(hydroxymethylidene)oxolan-2-one chemical structure, C11H18O3, CAS 62527-60-0
5-Hexyl-3-(hydroxymethylidene)oxolan-2-one
CAS 62527-60-0C11H18O3
3-(Hydroxymethylidene)-5-methyloxolan-2-one chemical structure, C6H8O3, CAS 62527-59-7
3-(Hydroxymethylidene)-5-methyloxolan-2-one
CAS 62527-59-7C6H8O3
3-[(Dimethylamino)methylidene]-5-methyloxolan-2-one chemical structure, C8H13NO2, CAS 62527-57-5
3-[(Dimethylamino)methylidene]-5-methyloxolan-2-one
CAS 62527-57-5C8H13NO2
(2-Oxooxolan-3-ylidene)acetaldehyde chemical structure, C6H6O3, CAS 61203-05-2
(2-Oxooxolan-3-ylidene)acetaldehyde
CAS 61203-05-2C6H6O3
3-(3-Hydroxy-2-methoxypropylidene)-5-methyloxolan-2-one chemical structure, C9H14O4, CAS 74824-94-5
3-(3-Hydroxy-2-methoxypropylidene)-5-methyloxolan-2-one
CAS 74824-94-5C9H14O4
Methyl 4-methylidene-5-oxooxolane-2-carboxylate chemical structure, C7H8O4, CAS 87497-18-5
Methyl 4-methylidene-5-oxooxolane-2-carboxylate
CAS 87497-18-5C7H8O4
3-{1-[(Prop-2-en-1-yl)amino]ethylidene}oxolan-2-one chemical structure, C9H13NO2, CAS 920312-83-0
3-{1-[(Prop-2-en-1-yl)amino]ethylidene}oxolan-2-one
CAS 920312-83-0C9H13NO2