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Murcko scaffold

Ring system with 2 rings and 12 atoms

137 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
137
With full pages
31
Scaffold SMILES

O=C1C=CC(c2ccccc2)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C=CC(c2ccccc2)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 137 chemicals

3-Acetyl-2-(2-fluorophenyl)-4-hydroxy-1,2-dihydropyrrol-5-one chemical structure, C12H10FNO3, CAS 312533-12-3
3-Acetyl-2-(2-fluorophenyl)-4-hydroxy-1,2-dihydropyrrol-5-one
CAS 312533-12-3C12H10FNO3
3-Acetyl-4-hydroxy-2-(4-methoxyphenyl)-1,2-dihydropyrrol-5-one chemical structure, C13H13NO4, CAS 298686-41-6
3-Acetyl-4-hydroxy-2-(4-methoxyphenyl)-1,2-dihydropyrrol-5-one
CAS 298686-41-6C13H13NO4
4-Acetyl-5-(4-chloro-phenyl)-1-(2-dimethylamino-ethyl)-3-hydroxy-1,5-dihydro-pyrrol-2-one chemical structure, C16H19ClN2O3, CAS 402514-09-4
4-Acetyl-5-(4-chloro-phenyl)-1-(2-dimethylamino-ethyl)-3-hydroxy-1,5-dihydro-pyrrol-2-one
CAS 402514-09-4C16H19ClN2O3
3-Acetyl-2-(2,4-dimethoxyphenyl)-4-hydroxy-1-(2-hydroxyethyl)-2H-pyrrol-5-one chemical structure, C16H19NO6, CAS 332149-33-4
3-Acetyl-2-(2,4-dimethoxyphenyl)-4-hydroxy-1-(2-hydroxyethyl)-2H-pyrrol-5-one
CAS 332149-33-4C16H19NO6
3-Acetyl-1-butyl-2-(2,4-dimethoxyphenyl)-4-hydroxy-2H-pyrrol-5-one chemical structure, C18H23NO5, CAS 425422-42-0
3-Acetyl-1-butyl-2-(2,4-dimethoxyphenyl)-4-hydroxy-2H-pyrrol-5-one
CAS 425422-42-0C18H23NO5
4-Acetyl-1-[2-(diethylamino)ethyl]-3-hydroxy-5-phenyl-1,5-dihydro-2H-pyrrol-2-one chemical structure, C18H24N2O3, CAS 425418-02-6
4-Acetyl-1-[2-(diethylamino)ethyl]-3-hydroxy-5-phenyl-1,5-dihydro-2H-pyrrol-2-one
CAS 425418-02-6C18H24N2O3
3-Acetyl-2-(2,4-dimethoxyphenyl)-4-hydroxy-1-methyl-2H-pyrrol-5-one chemical structure, C15H17NO5, CAS 352445-19-3
3-Acetyl-2-(2,4-dimethoxyphenyl)-4-hydroxy-1-methyl-2H-pyrrol-5-one
CAS 352445-19-3C15H17NO5
3-Acetyl-2-(3,4-dimethoxyphenyl)-4-hydroxy-1-methyl-2H-pyrrol-5-one chemical structure, C15H17NO5, CAS 332148-93-3
3-Acetyl-2-(3,4-dimethoxyphenyl)-4-hydroxy-1-methyl-2H-pyrrol-5-one
CAS 332148-93-3C15H17NO5
3-Acetyl-2-(4-bromophenyl)-4-hydroxy-1-methyl-2H-pyrrol-5-one chemical structure, C13H12BrNO3, CAS 165056-12-2
3-Acetyl-2-(4-bromophenyl)-4-hydroxy-1-methyl-2H-pyrrol-5-one
CAS 165056-12-2C13H12BrNO3
2-[3-Acetyl-2-(4-bromophenyl)-4-hydroxy-5-oxo-2H-pyrrol-1-yl]acetic acid chemical structure, C14H12BrNO5, CAS 162518-28-7
2-[3-Acetyl-2-(4-bromophenyl)-4-hydroxy-5-oxo-2H-pyrrol-1-yl]acetic acid
CAS 162518-28-7C14H12BrNO5
3-Acetyl-2-(4-bromophenyl)-4-hydroxy-1-(3-hydroxypropyl)-2H-pyrrol-5-one chemical structure, C15H16BrNO4, CAS 296769-87-4
3-Acetyl-2-(4-bromophenyl)-4-hydroxy-1-(3-hydroxypropyl)-2H-pyrrol-5-one
CAS 296769-87-4C15H16BrNO4
2-[3-Acetyl-2-(2-fluorophenyl)-4-hydroxy-5-oxo-2H-pyrrol-1-yl]acetic acid chemical structure, C14H12FNO5, CAS 296771-68-1
2-[3-Acetyl-2-(2-fluorophenyl)-4-hydroxy-5-oxo-2H-pyrrol-1-yl]acetic acid
CAS 296771-68-1C14H12FNO5
[3-Acetyl-2-(4-fluoro-phenyl)-4-hydroxy-5-oxo-2,5-dihydro-pyrrol-1-yl]-acetic acid chemical structure, C14H12FNO5, CAS 309270-57-3
[3-Acetyl-2-(4-fluoro-phenyl)-4-hydroxy-5-oxo-2,5-dihydro-pyrrol-1-yl]-acetic acid
CAS 309270-57-3C14H12FNO5
4-Acetyl-3-hydroxy-1-(3-hydroxypropyl)-5-phenyl-1,5-dihydro-2H-pyrrol-2-one chemical structure, C15H17NO4, CAS 296769-97-6
4-Acetyl-3-hydroxy-1-(3-hydroxypropyl)-5-phenyl-1,5-dihydro-2H-pyrrol-2-one
CAS 296769-97-6C15H17NO4
4-Acetyl-3-hydroxy-1-(2-hydroxyethyl)-5-phenyl-1,5-dihydro-2H-pyrrol-2-one chemical structure, C14H15NO4, CAS 332149-29-8
4-Acetyl-3-hydroxy-1-(2-hydroxyethyl)-5-phenyl-1,5-dihydro-2H-pyrrol-2-one
CAS 332149-29-8C14H15NO4
3-Acetyl-4-hydroxy-1-(2-hydroxyethyl)-2-(4-methoxyphenyl)-2H-pyrrol-5-one chemical structure, C15H17NO5, CAS 332149-30-1
3-Acetyl-4-hydroxy-1-(2-hydroxyethyl)-2-(4-methoxyphenyl)-2H-pyrrol-5-one
CAS 332149-30-1C15H17NO5
2-[3-Acetyl-4-hydroxy-2-(2-nitrophenyl)-5-oxo-2H-pyrrol-1-yl]acetic acid chemical structure, C14H12N2O7, CAS 332022-20-5
2-[3-Acetyl-4-hydroxy-2-(2-nitrophenyl)-5-oxo-2H-pyrrol-1-yl]acetic acid
CAS 332022-20-5C14H12N2O7
4-Acetyl-3-hydroxy-1-methyl-5-phenyl-1,5-dihydro-2H-pyrrol-2-one chemical structure, C13H13NO3, CAS 165056-11-1
4-Acetyl-3-hydroxy-1-methyl-5-phenyl-1,5-dihydro-2H-pyrrol-2-one
CAS 165056-11-1C13H13NO3
3-Acetyl-2-(4-bromophenyl)-4-hydroxy-1-(2-hydroxyethyl)-2H-pyrrol-5-one chemical structure, C14H14BrNO4, CAS 220128-05-2
3-Acetyl-2-(4-bromophenyl)-4-hydroxy-1-(2-hydroxyethyl)-2H-pyrrol-5-one
CAS 220128-05-2C14H14BrNO4
3-Acetyl-4-hydroxy-1-methyl-2-(4-nitrophenyl)-2H-pyrrol-5-one chemical structure, C13H12N2O5, CAS 139266-72-1
3-Acetyl-4-hydroxy-1-methyl-2-(4-nitrophenyl)-2H-pyrrol-5-one
CAS 139266-72-1C13H12N2O5
2-[3-Acetyl-2-(4-chlorophenyl)-4-hydroxy-5-oxo-2H-pyrrol-1-yl]acetic acid chemical structure, C14H12ClNO5, CAS 332022-23-8
2-[3-Acetyl-2-(4-chlorophenyl)-4-hydroxy-5-oxo-2H-pyrrol-1-yl]acetic acid
CAS 332022-23-8C14H12ClNO5
2-[3-Acetyl-4-hydroxy-2-(4-nitrophenyl)-5-oxo-2H-pyrrol-1-yl]acetic acid chemical structure, C14H12N2O7, CAS 5789-11-7
2-[3-Acetyl-4-hydroxy-2-(4-nitrophenyl)-5-oxo-2H-pyrrol-1-yl]acetic acid
CAS 5789-11-7C14H12N2O7
2-[3-Acetyl-4-hydroxy-2-(3-nitrophenyl)-5-oxo-2H-pyrrol-1-yl]acetic acid chemical structure, C14H12N2O7, CAS 311763-53-8
2-[3-Acetyl-4-hydroxy-2-(3-nitrophenyl)-5-oxo-2H-pyrrol-1-yl]acetic acid
CAS 311763-53-8C14H12N2O7
3-Acetyl-2-(4-fluorophenyl)-4-hydroxy-1-methyl-2H-pyrrol-5-one chemical structure, C13H12FNO3, CAS 222962-12-1
3-Acetyl-2-(4-fluorophenyl)-4-hydroxy-1-methyl-2H-pyrrol-5-one
CAS 222962-12-1C13H12FNO3