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Murcko scaffold

Ring system with 4 rings and 22 atoms

840 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
840
With full pages
15
Scaffold SMILES

O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 840 chemicals

2-(1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methylcyclobutyl)acetic acid chemical structure, C22H23NO4, CAS 2164347-93-5
2-(1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methylcyclobutyl)acetic acid
CAS 2164347-93-5C22H23NO4
1-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3,3-difluorocyclobutane-1-carboxylic acid chemical structure, C21H19F2NO4, CAS 2296988-69-5
1-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3,3-difluorocyclobutane-1-carboxylic acid
CAS 2296988-69-5C21H19F2NO4
2-(1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,3-difluorocyclobutyl)acetic acid chemical structure, C21H19F2NO4, CAS 2298347-66-5
2-(1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,3-difluorocyclobutyl)acetic acid
CAS 2298347-66-5C21H19F2NO4
1-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(trifluoromethyl)cyclobutanecarboxylic acid chemical structure, C21H18F3NO4, CAS 2357927-56-9
1-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(trifluoromethyl)cyclobutanecarboxylic acid
CAS 2357927-56-9C21H18F3NO4
2-(1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-fluorocyclobutyl)acetic acid chemical structure, C21H20FNO4, CAS 2386763-40-0
2-(1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-fluorocyclobutyl)acetic acid
CAS 2386763-40-0C21H20FNO4
(1s,3s)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(hydroxymethyl)cyclobutane-1-carboxylic acid chemical structure, C21H21NO5, CAS 2680901-87-3
(1s,3s)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(hydroxymethyl)cyclobutane-1-carboxylic acid
CAS 2680901-87-3C21H21NO5
2-(1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,3-dimethylcyclobutyl)acetic acid chemical structure, C23H25NO4, CAS 2172125-35-6
2-(1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,3-dimethylcyclobutyl)acetic acid
CAS 2172125-35-6C23H25NO4
1-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-fluoro-3-methyl-cyclobutanecarboxylic acid chemical structure, C21H20FNO4, CAS 2920427-25-2
1-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-fluoro-3-methyl-cyclobutanecarboxylic acid
CAS 2920427-25-2C21H20FNO4
1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(difluoromethyl)cyclobutane-1-carboxylic acid chemical structure, C21H19F2NO4, CAS 2243504-96-1
1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(difluoromethyl)cyclobutane-1-carboxylic acid
CAS 2243504-96-1C21H19F2NO4
N-Fmoc-N-cyclobutyl-glycine chemical structure, C21H21NO4, CAS 2138239-36-6
N-Fmoc-N-cyclobutyl-glycine
CAS 2138239-36-6C21H21NO4
3-[(1R,3S)-3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,2-dimethylcyclobutyl]propanoic acid chemical structure, C24H27NO4, CAS 2137033-14-6
3-[(1R,3S)-3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,2-dimethylcyclobutyl]propanoic acid
CAS 2137033-14-6C24H27NO4
rac-2-[(1R,2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]aceticacid,cis chemical structure, C21H21NO4, CAS 2580097-54-5
rac-2-[(1R,2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]aceticacid,cis
CAS 2580097-54-5C21H21NO4
(1-N-Fmoc-aminocyclobutyl)methanamine hydrochloride chemical structure, C20H23ClN2O2, CAS 2140449-03-0
(1-N-Fmoc-aminocyclobutyl)methanamine hydrochloride
CAS 2140449-03-0C20H23ClN2O2
(1-N-Fmoc-aminocyclobutyl)methanamine HCl chemical structure, C20H22N2O2
(1-N-Fmoc-aminocyclobutyl)methanamine HCl
C20H22N2O2
Fmoc-3,3-dimethylcyclobutane-1-methylamino-1-carboxylic acid chemical structure, C23H25NO4, CAS 2025106-27-6
Fmoc-3,3-dimethylcyclobutane-1-methylamino-1-carboxylic acid
CAS 2025106-27-6C23H25NO4
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4,4-difluorobutanoic acid chemical structure, C25H26F2N2O5, CAS 2171470-07-6
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4,4-difluorobutanoic acid
CAS 2171470-07-6C25H26F2N2O5
4-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-methylpentanoic acid chemical structure, C26H30N2O5, CAS 2172216-32-7
4-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-methylpentanoic acid
CAS 2172216-32-7C26H30N2O5
(3S)-3-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}pentanoic acid chemical structure, C26H30N2O5, CAS 2171209-40-6
(3S)-3-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}pentanoic acid
CAS 2171209-40-6C26H30N2O5
(3S)-3-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}butanoic acid chemical structure, C24H26N2O5, CAS 2171262-41-0
(3S)-3-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}butanoic acid
CAS 2171262-41-0C24H26N2O5
4-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3-hydroxy-3-methylbutanoic acid chemical structure, C25H28N2O6, CAS 2172188-54-2
4-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3-hydroxy-3-methylbutanoic acid
CAS 2172188-54-2C25H28N2O6
2-[N-(2,2-Dimethylpropyl)-1-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido]acetic acid chemical structure, C27H32N2O5, CAS 2171940-65-9
2-[N-(2,2-Dimethylpropyl)-1-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido]acetic acid
CAS 2171940-65-9C27H32N2O5
2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-methoxy-4-methylpentanoic acid chemical structure, C27H32N2O6, CAS 2171298-93-2
2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-methoxy-4-methylpentanoic acid
CAS 2171298-93-2C27H32N2O6
3-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]prop-2-ynoic acid chemical structure, C22H19NO4, CAS 2580217-07-6
3-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]prop-2-ynoic acid
CAS 2580217-07-6C22H19NO4
3-{[(tert-Butoxy)carbonyl]amino}-1-[ethyl({[(9H-fluoren-9-yl)methoxy]carbonyl})amino]cyclobutane-1-carboxylic acid chemical structure, C27H32N2O6, CAS 2137652-66-3
3-{[(tert-Butoxy)carbonyl]amino}-1-[ethyl({[(9H-fluoren-9-yl)methoxy]carbonyl})amino]cyclobutane-1-carboxylic acid
CAS 2137652-66-3C27H32N2O6